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Strain Registration

Strain: SHRSP/Izm

Symbol: SHRSP/Izm
Strain: SHRSP
Substrain: Izm
RGD ID: 631599
Citation ID: RRID:RGD_631599
Ontology ID: RS:0000770
Previously known as: NBRP Rat No: 0194; MDC-02-24
Type: inbred
Source: National BioResource Project for the Rat in Japan
Origin: Strain has been maintained at Kyoto University.
Inbred Generations: F110
Last Known Status: Live Animals
Research Usage Cardio Hypertension; Neurobiology





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
mean arterial blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
cell membrane potential
timed urine volume
partial pressure of blood carbon dioxide (Pco2)
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
serum triglyceride level
serum total cholesterol level
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
blood pH
partial pressure of blood oxygen
urine chloride level
absolute change in mean arterial blood pressure
plasma creatinine level
serum free fatty acids level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
absolute change in systolic blood pressure
both adrenal glands weight to body weight ratio
retroperitoneal fat pad weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
epididymal fat pad weight to body weight ratio
both testes wet weight to body weight ratio
percentage of study population developing cerebrovascular lesions during a period of time
brain infarction volume
head temperature
core body temperature
absolute change in urine norepinephrine level
stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
percent change in mean arterial blood pressure
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio
urine norepinephrine excretion rate
urine vanillylmandelic acid excretion rate

References

References - curated
# Reference Title Reference Citation
1. Fine linkage mapping of the blood pressure quantitative trait locus region on rat chromosome 1. Cui ZH, etal., Hypertens Res 2002 Jul;25(4):605-8.
2. Exaggerated response to cold stress in a congenic strain for the quantitative trait locus for blood pressure. Cui ZH, etal., J Hypertens 2004 Nov;22(11):2103-9.
3. Two genomic regions of chromosomes 1 and 18 explain most of the stroke susceptibility under salt loading in stroke-prone spontaneously hypertensive rat/Izm. Gandolgor TA, etal., Hypertension. 2013 Jul;62(1):55-61. doi: 10.1161/HYPERTENSIONAHA.111.00488. Epub 2013 May 20.
4. Establishment of a new animal model of metabolic syndrome: SHRSP fatty (fa/fa) rats. Hiraoka-Yamamoto J, etal., Clin Exp Pharmacol Physiol. 2004 Jan-Feb;31(1-2):107-9.
5. Relation of Blood Pressure Quantitative Trait Locus on Rat Chromosome 1 to Hyperactivity of Rostralventrolateral Medulla. Iigaya K, etal., Hypertension. 2008 Dec 1.
6. Genetic effects of blood pressure quantitative trait Loci on hypertension-related organ damage: evaluation using multiple congenic strains. Ishikawa N, etal., Hypertens Res. 2008 Sep;31(9):1773-9.
7. Isolation of a Chromosome 1 Region Affecting Blood Pressure and Vascular Disease Traits in the Stroke-Prone Rat Model. Kato N, etal., Hypertension 2003 Dec;42(6):1191-7. Epub 2003 Nov 17.
8. Aging and salt-loading modulate blood pressure QTLs in rats. Mashimo T, etal., Am J Hypertens 1999 Nov;12(11 Pt 1):1098-104.
9. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
10. RGD Strain RSO annotation pipeline RGD Automated Pipelines
11. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
12. Enhanced sympathetic control of renal function in rats congenic for the hypertension-related region on chromosome 1. Wang T, etal., Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1055-60.
13. SYMPATHETIC REGULATION OF RENAL FUNCTION IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS CONGENIC FOR CHROMOSOME 1 BLOOD PRESSURE QUANTITATIVE TRAIT LOCI. Wang T, etal., Clin Exp Pharmacol Physiol. 2008 Jun 18;.
14. Sympathetic regulation of the renal functions in rats reciprocally congenic for chromosome 1 blood pressure quantitative trait locus. Wang T, etal., Hypertens Res. 2008 Mar;31(3):561-8.
15. A 1.8-Mbp fragment on chromosome 1 affects sympathetic response to stress: evaluation in reciprocal congenic strains between stroke-prone spontaneously hypertensive rat and Wistar-Kyoto rat. Xiao B, etal., J Hypertens. 2010 Nov 8.
16. Sympathetic hyperreactivity to air-jet stress in the chromosome 1 blood pressure quantitative trait locus congenic rats. Yamazato M, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20.
17. Congenic removal of a QTL for blood pressure attenuates infarct size produced by middle cerebral artery occlusion in hypertensive rats. Yao H, etal., Physiol Genomics. 2007 Feb 27;.

Region

Strain QTL Data
Symbol Name Trait
Bp138 Blood pressure QTL 138 arterial blood pressure trait   (VT:2000000)    
Bp84 Blood pressure QTL 84 arterial blood pressure trait   (VT:2000000)    
Bp85 Blood pressure QTL 85 arterial blood pressure trait   (VT:2000000)    
Bp86 Blood pressure QTL 86 arterial blood pressure trait   (VT:2000000)    
Bp87 Blood pressure QTL 87 arterial blood pressure trait   (VT:2000000)    
Strs4 Sensitivity to stroke QTL 4 cerebrum integrity trait   (VT:0010549)    
Strs5 Sensitivity to stroke QTL 5 cerebrum integrity trait   (VT:0010549)    
Strs6 Sensitivity to stroke QTL 6 cerebrum integrity trait   (VT:0010549)    
Strs7 Sensitivity to stroke QTL 7 cerebrum integrity trait   (VT:0010549)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease susceptible to elevated blood pressure 619634

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-10 SHRSP/Izm    SHRSP/Izm    Name updated 68913 APPROVED