RGD Reference Report - Aging and salt-loading modulate blood pressure QTLs in rats. - Rat Genome Database

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Aging and salt-loading modulate blood pressure QTLs in rats.

Authors: Mashimo, T  Nabika, T  Matsumoto, C  Tamada, T  Ueno, K  Sawamura, M  Ikeda, K  Kato, N  Nara, Y  Yamori, Y 
Citation: Mashimo T, etal., Am J Hypertens 1999 Nov;12(11 Pt 1):1098-104.
RGD ID: 619634
Pubmed: PMID:10604486   (View Abstract at PubMed)

To evaluate the effects of nongenetic factors, aging, and salt-loading on the quantitative trait loci (QTLs) for blood pressure (BP), we conducted a genome-wide linkage analysis using multiple sets of BP measurements in 125 male F2 generation cross derived from stroke-prone spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. The experiment was arranged in two stages. In the first stage, corresponding to the developing period of the rats, BP was measured repeatedly without loading of salt; this continued until the rats were 5 months of age. In the second stage, after the baseline BP leveled off, 1% salt water was given to the rats and BP was monitored for the subsequent 7 months. Genome scanning was performed using 201 markers. In the developing period, three QTLs were identified on chromosomes 1, 3, and 4 (logarithmic odds [LOD] scores of 5.6, 3.1, and 3.2, respectively), which had peaks at 8 or 10 weeks of age. In the latter salt-loading stage, QTLs for BP were detected on chromosomes 1 and 10 (LOD scores 4.6 and 4.5, respectively). When the BP increase during salt-loading was analyzed as a phenotype, however, only the region on chromosome 10 showed linkage at a suggestive level (LOD score 3.2). The present study provides experimental evidence that QTLs for BP could be modulated by nongenetic factors, such as aging and salt-loading.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp84Rathypertension  IDA  RGD 
Bp85Rathypertension  IDA  RGD 
Bp86Rathypertension  IDA  RGD 
Bp87Rathypertension  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Objects Annotated

Bp84  (Blood pressure QTL 84)
Bp85  (Blood pressure QTL 85)
Bp86  (Blood pressure QTL 86)
Bp87  (Blood pressure QTL 87)

WKY/Izm  (Wistar-Kyoto)

Objects referenced in this article
Marker D10Arb12 D10Arb12 Rattus norvegicus

Additional Information