RGD Reference Report - Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats. - Rat Genome Database

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Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats.

Authors: Garrett, MR  Rapp, JP 
Citation: Garrett MR and Rapp JP, Physiol Genomics 2002 Feb 28;8(2):81-6.
RGD ID: 619649
Pubmed: (View Article at PubMed) PMID:11875185
DOI: Full-text: DOI:10.1152/physiolgenomics.00080.2001

Previously we reported the construction of a congenic strain, S.LEW, spanning a large region of rat chromosome 5. The Lewis (LEW) strain was the donor, and the Dahl salt-sensitive (S) strain was the recipient. The congenic strain included a blood pressure quantitative trait locus (QTL). In the present work, a series of nine congenic substrains were constructed from S.LEW which defined two closely linked blood pressure QTL in the region previously thought to contain only one. LEW low-blood-pressure alleles at both QTL were required for a major effect on blood pressure. Neither LEW allele alone had a significant effect on blood pressure. The two QTL were localized to regions 6.3 and 4.6 cM, and these were 1.0 cM apart.

Annotation

Disease Annotations    
hypertension  (IAGP)
Hypotension  (IDA)

Phenotype Annotations    

Mammalian Phenotype
Objects referenced in this article
Strain WKY.SHRSP-(D1Rat112-D1Wox29)/Izm null Rattus norvegicus

Additional Information