RGD Reference Report - Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats. - Rat Genome Database

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Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats.

Authors: Garrett, MR  Rapp, JP 
Citation: Garrett MR and Rapp JP, Physiol Genomics 2002 Feb 28;8(2):81-6.
RGD ID: 619649
Pubmed: PMID:11875185   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00080.2001   (Journal Full-text)

Previously we reported the construction of a congenic strain, S.LEW, spanning a large region of rat chromosome 5. The Lewis (LEW) strain was the donor, and the Dahl salt-sensitive (S) strain was the recipient. The congenic strain included a blood pressure quantitative trait locus (QTL). In the present work, a series of nine congenic substrains were constructed from S.LEW which defined two closely linked blood pressure QTL in the region previously thought to contain only one. LEW low-blood-pressure alleles at both QTL were required for a major effect on blood pressure. Neither LEW allele alone had a significant effect on blood pressure. The two QTL were localized to regions 6.3 and 4.6 cM, and these were 1.0 cM apart.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension inducedIAGPcontrolled sodium content diet619649 RGD 
hypertension inducedIAGPcontrolled sodium content diet619649compared to SS/JrRGD 
hypertension MODEL: inducedIAGPcontrolled sodium content diet619649compared to SS.LEW-(D5Rat130-D5Mco10)/Jr and MMO:0000031RGD 
Hypotension  IDA 619649; 619649 RGD 

Objects referenced in this article
Strain WKY.SHRSP-(D1Rat112-D1Wox29)/Izm null Rattus norvegicus

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