| Note Type |
Note |
Reference |
| strain_characteristics |
Some demonstrate heritable biventricular cardiac hypertrophy, providing a model of volume-load hypertrophy (Pfeiffer et al 1979 using breeding stock obtained from the NIH in 1973 at F5). Similarly, Kuribayashi et al (1988) found a high incidence of a range of cardiac abnormalities in WKY/NCrj substrain rats. Belledonne et al (1979) showed that WKY/Tac rats are sensitive to sodium chloride-induced hypertension and have abnormal acid and ammonium excretion. Sensitive to the induction of ulcers by stress (1/4) (Pare 1989). Hyperresponsive to a novel environment as indicated by delay in entering the open field, increased grooming, reduced rearing, and reduced locomotion. Plasma ACTH levels were found to be 67% higher than in BN rats, with an inverse correlation with longevity (Tizabi et al, 1992, Gilad et al, 1993). Relatively sensitive to the induction of experimental autoimmune glomerulonephritis (1/4, cf F344)(Sado et al 1986). Like the COP strain, resistant to the development of induced and spontaneous mammary carcinomas due to one homozygous copy of a mammary tumour suppressor gene (Haag et al 1992). Resistant to the induction of glandular stomach adenocarcinomas following treatment with catechol (contrast LEW, Wistar and Sprague-Dawley) (Tanaka et al, 1995) Compared with SHR/N, ACI and F344/N, has low levels of cytochrome Cyp2C11 but relatively high levels of S-warfarin 4-and 8-hydroxylase activities (Kitareewan and Walz, 1994). Epitope specificities of collagen-induced arthritis studied by Cremer et al (1992). Resistant to the development of mammary carcinomas (both spontaneous and induced) due to a suppressor gene which appears to be similar or identical to that carried by strain COP. However, WKY also carries one or more susceptibility genes (Haag et al 1992). Low 10-week body weight in males (4/23) (Tanase et al 1982). Bellhorn et al (1987) found that rats of the substrain maintained by Charles River Inc. develop an outer retinal degeneration by middle age. A congenic strain carrying the fatty gene (fa) (N8-N10) has been described by Peterson et al (1990a). It appears in many ways to be similar to strain WDF/Ta-fa, with non-insulin-dependent diabetes mellitus. Slow acetylator due to polymorphism of N-acetyltransferase (like NSD but contrast PETH) (Juberg et al, 1991). This strain is used as a control for the SHR/N strain in accordance with the recommendations of the Committee on Care and Use of Spontaneously Hypertensive (SHR) Rats of the National Research Council. |
1004
|
| strain_characteristics |
Some demonstrate heritable biventricular cardiac hypertrophy, providing a model of volume-load hypertrophy (Pfeiffer et al 1979 using breeding stock obtained from the NIH in 1973 at F5). Similarly, Kuribayashi et al (1988) found a high incidence of a range of cardiac abnormalities in WKY/NCrj substrain rats. Belledonne et al (1979) showed that WKY/Tac rats are sensitive to sodium chloride-induced hypertension and have abnormal acid and ammonium excretion. Sensitive to the induction of ulcers by stress (1/4) (Pare 1989). Hyperresponsive to a novel environment as indicated by delay in entering the open field, increased grooming, reduced rearing, and reduced locomotion. Plasma ACTH levels were found to be 67% higher than in BN rats, with an inverse correlation with longevity (Tizabi et al, 1992, Gilad et al, 1993). Relatively sensitive to the induction of experimental autoimmune glomerulonephritis (1/4, cf F344)(Sado et al 1986). Like the COP strain, resistant to the development of induced and spontaneous mammary carcinomas due to one homozygous copy of a mammary tumour suppressor gene (Haag et al 1992). Resistant to the induction of glandular stomach adenocarcinomas following treatment with catechol (contrast LEW, Wistar and Sprague-Dawley) (Tanaka et al, 1995) Compared with SHR/N, ACI and F344/N, has low levels of cytochrome Cyp2C11 but relatively high levels of S-warfarin 4-and 8-hydroxylase activities (Kitareewan and Walz, 1994). Epitope specificities of collagen-induced arthritis studied by Cremer et al (1992). Resistant to the development of mammary carcinomas (both spontaneous and induced) due to a suppressor gene which appears to be similar or identical to that carried by strain COP. However, WKY also carries one or more susceptibility genes (Haag et al 1992). Low 10-week body weight in males (4/23) (Tanase et al 1982). Bellhorn et al (1987) found that rats of the substrain maintained by Charles River Inc. develop an outer retinal degeneration by middle age. A congenic strain carrying the fatty gene (fa) (N8-N10) has been described by Peterson et al (1990a). It appears in many ways to be similar to strain WDF/Ta-fa, with non-insulin-dependent diabetes mellitus. Slow acetylator due to polymorphism of N-acetyltransferase (like NSD but contrast PETH) (Juberg et al, 1991). This strain is used as a control for the SHR/N strain in accordance with the recommendations of the Committee on Care and Use of Spontaneously Hypertensive (SHR) Rats of the National Research Council. |
634612
|
| strain_life_disease |
Non-Neoplastic (Spontaneous): Most WKY have ventricular weight-to-body weight ratios similar to American Normotensive Wistar rats, but a subset of WKY (original stock from NIH) demonstrating an inheritable transmission of biventricular cardiac hypertrophy (BVH) has been identified. WKY with BVH provide a natural model of volume load hypertrophy. Use of WKY for comparison with SHR should exclude animals with BVH. |
1004
|
| strain_life_disease |
Non-Neoplastic (Spontaneous): Most WKY have ventricular weight-to-body weight ratios similar to American Normotensive Wistar rats, but a subset of WKY (original stock from NIH) demonstrating an inheritable transmission of biventricular cardiac hypertrophy (BVH) has been identified. WKY with BVH provide a natural model of volume load hypertrophy. Use of WKY for comparison with SHR should exclude animals with BVH. |
634612
|
| strain_phys_biochem |
Adult WKY have been an inability to excrete acid appropriately after acute or chronic acid loading compared to Sprague-Dawley rats. |
1004
|
| strain_phys_biochem |
Adult WKY have been an inability to excrete acid appropriately after acute or chronic acid loading compared to Sprague-Dawley rats. |
634612
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