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Strain: WKY/N

Symbol: WKY/N
Strain: WKY
Substrain: N
RGD ID: 70454
RRID: RGD_70454
Ontology ID: RS:0000714
Also known as: RRRC:00190
Type: inbred
Source: NIH Autoimmune Rat Model Repository and Development Center, Rat Resource and Research Center
Origin: National Institutes of Health in 1971 from outbred Wistar stock from Kyoto School of Medicine. Inbred as a normotensive control strain for SHR (Hanesn et al 1973), though there is some controversy about the validity of such use (see Rapp 1987). Johnson et al (1992) found large genetic differences using restriction fragment length polymorphisms between WKY and SHR, comparable to the maximum divergence possible between unrelated humans. Also, breeding stock of ths strain was distributed before F20, possibly resulting in the emergence of a number of strains or substrains (Kurtz and Morris 1987, Kurtz et al 1989). It is therefore essential that subline codes are always used in designating this strain.
Genetic Markers: a, B, c, h, P, R
Coat Color: Albino
Inbred Generations: F46 (N)
Last Known Status: Cryopreserved Embryo (as of 2019-02-01)





References


Region

Strain QTL Data
Symbol Name Trait
Bp155 Blood pressure QTL 155 arterial blood pressure trait   (VT:2000000)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
WKY/N (KNAW) 553
WKY/N (KNAW) 621
WKY/N (MCW) 1294


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Some demonstrate heritable biventricular cardiac hypertrophy, providing a model of volume-load hypertrophy (Pfeiffer et al 1979 using breeding stock obtained from the NIH in 1973 at F5). Similarly, Kuribayashi et al (1988) found a high incidence of a range of cardiac abnormalities in WKY/NCrj substrain rats. Belledonne et al (1979) showed that WKY/Tac rats are sensitive to sodium chloride-induced hypertension and have abnormal acid and ammonium excretion. Sensitive to the induction of ulcers by stress (1/4) (Pare 1989). Hyperresponsive to a novel environment as indicated by delay in entering the open field, increased grooming, reduced rearing, and reduced locomotion. Plasma ACTH levels were found to be 67% higher than in BN rats, with an inverse correlation with longevity (Tizabi et al, 1992, Gilad et al, 1993). Relatively sensitive to the induction of experimental autoimmune glomerulonephritis (1/4, cf F344)(Sado et al 1986). Like the COP strain, resistant to the development of induced and spontaneous mammary carcinomas due to one homozygous copy of a mammary tumour suppressor gene (Haag et al 1992). Resistant to the induction of glandular stomach adenocarcinomas following treatment with catechol (contrast LEW, Wistar and Sprague-Dawley) (Tanaka et al, 1995) Compared with SHR/N, ACI and F344/N, has low levels of cytochrome Cyp2C11 but relatively high levels of S-warfarin 4-and 8-hydroxylase activities (Kitareewan and Walz, 1994). Epitope specificities of collagen-induced arthritis studied by Cremer et al (1992). Resistant to the development of mammary carcinomas (both spontaneous and induced) due to a suppressor gene which appears to be similar or identical to that carried by strain COP. However, WKY also carries one or more susceptibility genes (Haag et al 1992). Low 10-week body weight in males (4/23) (Tanase et al 1982). Bellhorn et al (1987) found that rats of the substrain maintained by Charles River Inc. develop an outer retinal degeneration by middle age. A congenic strain carrying the fatty gene (fa) (N8-N10) has been described by Peterson et al (1990a). It appears in many ways to be similar to strain WDF/Ta-fa, with non-insulin-dependent diabetes mellitus. Slow acetylator due to polymorphism of N-acetyltransferase (like NSD but contrast PETH) (Juberg et al, 1991). This strain is used as a control for the SHR/N strain in accordance with the recommendations of the Committee on Care and Use of Spontaneously Hypertensive (SHR) Rats of the National Research Council. 1004
strain_characteristics Some demonstrate heritable biventricular cardiac hypertrophy, providing a model of volume-load hypertrophy (Pfeiffer et al 1979 using breeding stock obtained from the NIH in 1973 at F5). Similarly, Kuribayashi et al (1988) found a high incidence of a range of cardiac abnormalities in WKY/NCrj substrain rats. Belledonne et al (1979) showed that WKY/Tac rats are sensitive to sodium chloride-induced hypertension and have abnormal acid and ammonium excretion. Sensitive to the induction of ulcers by stress (1/4) (Pare 1989). Hyperresponsive to a novel environment as indicated by delay in entering the open field, increased grooming, reduced rearing, and reduced locomotion. Plasma ACTH levels were found to be 67% higher than in BN rats, with an inverse correlation with longevity (Tizabi et al, 1992, Gilad et al, 1993). Relatively sensitive to the induction of experimental autoimmune glomerulonephritis (1/4, cf F344)(Sado et al 1986). Like the COP strain, resistant to the development of induced and spontaneous mammary carcinomas due to one homozygous copy of a mammary tumour suppressor gene (Haag et al 1992). Resistant to the induction of glandular stomach adenocarcinomas following treatment with catechol (contrast LEW, Wistar and Sprague-Dawley) (Tanaka et al, 1995) Compared with SHR/N, ACI and F344/N, has low levels of cytochrome Cyp2C11 but relatively high levels of S-warfarin 4-and 8-hydroxylase activities (Kitareewan and Walz, 1994). Epitope specificities of collagen-induced arthritis studied by Cremer et al (1992). Resistant to the development of mammary carcinomas (both spontaneous and induced) due to a suppressor gene which appears to be similar or identical to that carried by strain COP. However, WKY also carries one or more susceptibility genes (Haag et al 1992). Low 10-week body weight in males (4/23) (Tanase et al 1982). Bellhorn et al (1987) found that rats of the substrain maintained by Charles River Inc. develop an outer retinal degeneration by middle age. A congenic strain carrying the fatty gene (fa) (N8-N10) has been described by Peterson et al (1990a). It appears in many ways to be similar to strain WDF/Ta-fa, with non-insulin-dependent diabetes mellitus. Slow acetylator due to polymorphism of N-acetyltransferase (like NSD but contrast PETH) (Juberg et al, 1991). This strain is used as a control for the SHR/N strain in accordance with the recommendations of the Committee on Care and Use of Spontaneously Hypertensive (SHR) Rats of the National Research Council. 634612
strain_life_disease Non-Neoplastic (Spontaneous): Most WKY have ventricular weight-to-body weight ratios similar to American Normotensive Wistar rats, but a subset of WKY (original stock from NIH) demonstrating an inheritable transmission of biventricular cardiac hypertrophy (BVH) has been identified. WKY with BVH provide a natural model of volume load hypertrophy. Use of WKY for comparison with SHR should exclude animals with BVH. 1004
strain_life_disease Non-Neoplastic (Spontaneous): Most WKY have ventricular weight-to-body weight ratios similar to American Normotensive Wistar rats, but a subset of WKY (original stock from NIH) demonstrating an inheritable transmission of biventricular cardiac hypertrophy (BVH) has been identified. WKY with BVH provide a natural model of volume load hypertrophy. Use of WKY for comparison with SHR should exclude animals with BVH. 634612
strain_phys_biochem Adult WKY have been an inability to excrete acid appropriately after acute or chronic acid loading compared to Sprague-Dawley rats. 1004
strain_phys_biochem Adult WKY have been an inability to excrete acid appropriately after acute or chronic acid loading compared to Sprague-Dawley rats. 634612

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-04-19 WKY/N    WKY/N    Name updated 68913 APPROVED
2012-04-19 WKY/N    WKY/N    Name updated 68913 APPROVED