RGD Reference Report - MR molecular imaging of aortic angiogenesis. - Rat Genome Database

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MR molecular imaging of aortic angiogenesis.

Authors: Cai, Kejia  Caruthers, Shelton D  Huang, Wenjing  Williams, Todd A  Zhang, Huiying  Wickline, Samuel A  Lanza, Gregory M  Winter, Patrick M 
Citation: Cai K, etal., JACC Cardiovasc Imaging. 2010 Aug;3(8):824-32. doi: 10.1016/j.jcmg.2010.03.012.
RGD ID: 21408581
Pubmed: PMID:20705262   (View Abstract at PubMed)
PMCID: PMC3425389   (View Article at PubMed Central)
DOI: DOI:10.1016/j.jcmg.2010.03.012   (Journal Full-text)


OBJECTIVES: The objectives of this study were to use magnetic resonance (MR) molecular imaging to 1) characterize the aortic neovascular development in a rat model of atherosclerosis and 2) monitor the effects of an appetite suppressant on vascular angiogenesis progression.
BACKGROUND: The James C. Russell:LA corpulent rat strain (JCR:LA-cp) is a model of metabolic syndrome characterized by obesity, insulin resistance, hyperlipidemia, and vasculopathy, although plaque neovascularity has not been reported in this strain. MR molecular imaging with alpha(nu)beta(3)-targeted nanoparticles can serially map angiogenesis in the aortic wall and monitor the progression of atherosclerosis.
METHODS: Six-week old JCR:LA-cp (+/?; lean, n = 5) and JCR:LA-cp (cp/cp; obese, n = 5) rats received standard chow, and 6 obese rats were fed the appetite suppressant benfluorex over 16 weeks. Body weight and food consumption were recorded at baseline and weeks 4, 8, 12, and 16. MR molecular imaging with alpha(nu)beta(3)-targeted paramagnetic nanoparticles was performed at weeks 0, 8, and 16. Fasted plasma triglyceride, cholesterol, and glucose were measured immediately before MR scans. Plasma insulin and leptin levels were assayed at weeks 8 and 16.
RESULTS: Benfluorex reduced food consumption (p < 0.05) to the same rate as lean animals, but had no effect on serum cholesterol or triglyceride levels. MR (3-T) aortic signal enhancement with alpha(nu)beta(3)-targeted nanoparticles was initially equivalent between groups, but increased (p < 0.05) in the untreated obese animals over 16 weeks. No signal change (p > 0.05) was observed in the benfluorex-treated or lean rat groups. MR differences paralleled adventitial microvessel counts, which increased (p < 0.05) among the obese rats and were equivalently low in the lean and benfluorex-treated animals (p > 0.05). Body weight, insulin, and leptin were decreased (p < 0.05) from the untreated obese animals by benfluorex, but not to the lean control levels (p < 0.05).
CONCLUSIONS: Neovascular expansion is a prominent feature of the JCR:LA-cp model. MR imaging with alpha(nu)beta(3)-targeted nanoparticles provided a noninvasive assessment of angiogenesis in untreated obese rats, which was suppressed by benfluorex.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LA-cp/NJcrRatatherosclerosis MODEL: spontaneousIAGP compared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatatherosclerosis treatmentIAGP  RGD 
LA-cp/NJcrRatobesity MODEL: spontaneousIAGP compared to lean LA/NJcr+/+ ratsRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LA-cp/NJcrRatatherosclerotic lesions treatmentIAGPBenfluorexcompared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased abdominal adipose tissue amount treatmentIAGPBenfluorexcompared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased body weight treatmentIAGPBenfluorexcompared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased circulating cholesterol level treatmentIAGPBenfluorexcompared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased circulating insulin level treatmentIAGPBenfluorexcompared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased circulating leptin level treatmentIAGPBenfluorexcompared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased circulating triglyceride level treatmentIAGPBenfluorexcompared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased food intake treatmentIAGPBenfluorexcompared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatincreased susceptibility to atherosclerosis treatmentIAGPBenfluorexcompared to lean LA/NJcr+/+ ratsRGD 
LA-cp/NJcrRatpathological neovascularization treatmentIAGPBenfluorexcompared to lean LA/NJcr+/+ ratsRGD 
Objects Annotated

Strains
LA-cp/NJcr  (NA)


Additional Information