RGD Reference Report - A new spontaneously diabetic non-obese Torii rat strain with severe ocular complications. - Rat Genome Database

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A new spontaneously diabetic non-obese Torii rat strain with severe ocular complications.

Authors: Shinohara, M  Masuyama, T  Shoda, T  Takahashi, T  Katsuda, Y  Komeda, K  Kuroki, M  Kakehashi, A  Kanazawa, Y 
Citation: Shinohara M, etal., Int J Exp Diabetes Res 2000;1(2):89-100.
RGD ID: 628479
Pubmed: PMID:11469401   (View Abstract at PubMed)
PMCID: PMC2477755   (View Article at PubMed Central)

A new spontaneously diabetic strain of the Sprague-Dawley rat was established in 1997 and named the SDT (Spontaneously Diabetic Torii) rat. In this research, we investigated the characteristics of the disease condition in the SDT rats. The time of onset of glucosuria was different between male and female SDT rats; glucosuria appeared at approximately 20 weeks of age in male rats and at approximately 45 weeks of age in female rats. A cumulative incidence of diabetes of 100% was noted by 40 weeks of age in male rats, while it was only 33.3% even by 65 weeks of age in female rats. The survival rate up to 65 weeks of age was 92.9% in male rats and 97.4% in female rats. Glucose intolerance was observed in male rats from 16 weeks of age. The clinical characteristics of the male SDT rats were (1) hyperglycemia and hypoinsulinemia (from 25 weeks of age); (2) long-term survival without insulin treatment; (3) hypertriglyceridemia (by 35 weeks of age); however, no obesity was noted in any of the male rats. The histopathological characteristics of the male rats with diabetes mellitus (DM) were (1) fibrosis of the pancreatic islets (by 25 weeks of age); (2) cataract (by 40 weeks of age); (3) tractional retinal detachment with fibrous proliferation (by 70 weeks of age) and (4) massive hemorrhaging in the anterior chamber (by 77 weeks of age). These clinical and histopathological characteristics of the disease in SDT rats resemble those of human Type 2 diabetes with insulin hyposecretion. In conclusion, SDT rat is considered to be a potentially useful model for studies of diabetic retinopathy encountered in humans.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SDT/JclRatcataract  IAGP compared to Crj:CD(SD) controlsRGD 
Crlj:CD(SD)Ratdiabetes mellitus MODEL: controlIAGP compared to SDT/JclRGD 
SDT/JclRatdiabetes mellitus MODEL: spontaneousIAGP compared to Crj:CD(SD) controls more ...RGD 
Crlj:CD(SD)Ratdiabetic retinopathy MODEL: controlIAGP compared to SDT/JclRGD 
SDT/JclRatdiabetic retinopathy MODEL: spontaneousIAGP compared to Crj:CD(SD) controls more ...RGD 
SDT/JclRatretinal detachment  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SDT/JclRatabnormal lens fiber morphology  IAGP  RGD 
SDT/JclRatabnormal pancreas morphology  IAGP  RGD 
SDT/JclRatabnormal triglyceride level  IAGP  RGD 
SDT/JclRatcataract  IAGP  RGD 
SDT/JclRatdecreased body weight  IAGP compared to Crj:CDSD controls and sexual dimorphismRGD 
SDT/JclRatdecreased circulating insulin level  IAGP  RGD 
SDT/JclRatdecreased pancreatic islet number  IAGP  RGD 
SDT/JclRatimpaired glucose tolerance  IAGP  RGD 
SDT/JclRatincreased circulating glucose level  IAGP  RGD 
SDT/JclRatincreased urine glucose level  IAGP  RGD 
SDT/JclRatpancreas fibrosis  IAGP  RGD 
SDT/JclRatpolydipsia  IAGP associated with diabetes mellitusRGD 
SDT/JclRatpolyphagia  IAGP associated with diabetes mellitusRGD 
SDT/JclRatpolyuria  IAGP associated with diabetes mellitusRGD 
Objects Annotated

Strains
Crlj:CD(SD)  (NA)
SDT/Jcl  (NA)

Objects referenced in this article
Strain SD/Rij null Rattus norvegicus

Additional Information