RGD Reference Report - Genetic relationship between a lymphocyte membrane abnormality and blood pressure in spontaneously hypertensive stroke prone and Wistar-Kyoto rats. - Rat Genome Database

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Genetic relationship between a lymphocyte membrane abnormality and blood pressure in spontaneously hypertensive stroke prone and Wistar-Kyoto rats.

Authors: Furspan, P B  Jokelainen, P T  Sing, C F  Bohr, D F 
Citation: Furspan PB, etal., J Hypertens. 1987 Jun;5(3):293-7. doi: 10.1097/00004872-198706000-00005.
RGD ID: 36049805
Pubmed: PMID:3611778   (View Abstract at PubMed)
DOI: DOI:10.1097/00004872-198706000-00005   (Journal Full-text)

The fluxes of sodium and potassium across the lymphocyte membrane in spontaneously hypertensive, stroke prone rats (SHRSP) are greater than those in Wistar-Kyoto rats (WKY). In order to define the relationship of these abnormal membrane traits to arterial pressure elevation, their distributions were studied in F1, F2, and backcross progeny of the cross of SHRSP and WKY rats. In the F1 generation, arterial pressure and potassium efflux values resembled those of the WKY parents suggesting that these traits are dominant in the normotensive rat; sodium influx values resembled those of the SHRSP parents. There was poor correlation (r = 0.45) between blood pressure and sodium influx in the F2 generation. There was a high correlation between blood pressure and potassium efflux (r = 0.86), suggesting that these two traits may be under the control of a common genetic mechanism.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension MODEL: spontaneousIAGP 36049805compared to WKY/NRGD 
hypertension treatmentIAGP 36049805 RGD 
hypertension MODEL: controlIAGP 36049805compared to SHRSP/A3NRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
abnormal potassium ion homeostasis susceptibilityIAGP 36049805compared to WKY/NRGD 
abnormal renal sodium ion transport susceptibilityIAGP 36049805compared to WKY/NRGD 
increased systemic arterial systolic blood pressure susceptibilityIAGP 36049805compared to WKY/NRGD 

Objects Annotated

Strains
SHRSP/A3N  (NA)
WKY/N  (NA)


Additional Information