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Strain Registration

General

Strain: SHRSP/A3N
Symbol:	SHRSP/A3N
Strain:	SHRSP
Substrain:	A3N
RGD ID:	728184
Citation ID:	RRID:RGD_728184
Ontology ID:	RS:0000775
Type:	inbred
Available Source:	Not Available
Origination:	NIH Autoimmune Rat Model Repository and Development Center
Description:	To NIH in 1975 from Yamori at F36. SHR was isolated from Wistar Kyoto rats by Okamoto and Aoki in 1963. SHR was later separated into several sublines; the A3 subline was found to have a high incidence of cerebrovascular lesions. (517)
Genetic Markers:	c Albino
Inbred Generations:	F47
Last Known Status:	Extinct (as of 2020-04-21)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cardiovascular system disease (IAGP)

hypertension (IAGP)

proteinuria (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal potassium ion homeostasis (IAGP)

abnormal renal sodium ion transport (IAGP)

cardiac hypertrophy (IAGP)

decreased body weight (IAGP)

decreased cardiac output (IAGP)

decreased cardiac stroke volume (IAGP)

decreased survivor rate (IAGP)

glomerulosclerosis (IAGP)

increased blood urea nitrogen level (IAGP)

increased systemic arterial systolic blood pressure (IAGP)

increased urine protein level (IAGP)

renal cast (IAGP)

renal fibrosis (IAGP)

renal interstitial fibrosis (IAGP)

renal ischemia (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

heart rate

systolic blood pressure

body weight

heart wet weight

kidney weight

both adrenal glands wet weight

both testes wet weight

end-systolic volume

end-diastolic volume

both kidneys wet weight to body weight ratio

serum triglyceride level

serum total cholesterol level

serum glucose level

serum free fatty acids level

plasma aldosterone level

serum alanine aminotransferase activity level

serum aspartate aminotransferase activity level

serum urea nitrogen level

thymus weight

pituitary gland weight

serum lactate dehydrogenase activity level

urine total protein excretion rate

serum creatine kinase activity level

ovary wet weight

kidney tubule regeneration foci count

kidney total tubule cast count

interstitial nephritis foci count

renal fibrosis foci count

kidney glomerular lesion count

net sodium influx to blood lymphocyte dry weight ratio per unit time

net potassium efflux to blood lymphocyte dry weight ratio per unit time

plasma proANF 31-67 peptide level

ratio of deaths related to chronic hypertension to total study population during a period of time

ratio of deaths related to left ventricular hypertrophy to total study population during a period of time

References

References - curated

#	Reference Title	Reference Citation
1.	The angiotensin type 1 receptor antagonist, eprosartan, attenuates the progression of renal disease in spontaneously hypertensive stroke-prone rats with accelerated hypertension.	Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21.
2.	Carvedilol prevents and reverses hypertrophy-induced cardiac dysfunction.	Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4.
3.	Genetic relationship between a lymphocyte membrane abnormality and blood pressure in spontaneously hypertensive stroke prone and Wistar-Kyoto rats.	Furspan PB, etal., J Hypertens. 1987 Jun;5(3):293-7. doi: 10.1097/00004872-198706000-00005.
4.	NIH Rat Strain Data	NIH Rat Strain Data
5.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
6.	Enrasentan improves survival, limits left ventricular remodeling, and preserves myocardial performance in hypertensive cardiac hypertrophy and dysfunction.	Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013.
7.	Renoprotective effects of carvedilol in hypertensive-stroke prone rats may involve inhibition of TGF beta expression.	Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329.

Region

Additional Information

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2015-04-07	SHRSP/A3N	SHRSP/A3N	Name updated	68913	APPROVED
2015-04-07	SHRSP/A3N	SHRSP/A3N	Name updated	68913	APPROVED
2013-04-15	SHRSP/A3N	SHRSP/A3N	Name updated	68913	APPROVED
2013-04-15	SHRSP/A3N	SHRSP/A3N	Name updated	68913	APPROVED

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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SHRSP/A3N

Mammalian Phenotype

Related Phenotype Data for Term "SHRSP/A3N" (RS:0000775)