Serpine1 (serpin family E member 1) - Rat Genome Database

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Gene: Serpine1 (serpin family E member 1) Rattus norvegicus
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Symbol: Serpine1
Name: serpin family E member 1
RGD ID: 3249
Description: Enables protease binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to ketone; and cellular response to peptide hormone stimulus. Located in chromaffin granule and extracellular space. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); diabetes mellitus (multiple); end stage renal disease; and renal fibrosis. Biomarker of several diseases, including acute necrotizing pancreatitis; glomerulosclerosis (multiple); lung disease (multiple); middle cerebral artery infarction; and muscular atrophy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); liver disease (multiple); lung disease (multiple); and retinal vascular disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1); PARTICIPATES IN oxygen homeostasis pathway; fibrinolysis pathway; hypoxia inducible factor pathway; INTERACTS WITH (S)-colchicine; (S)-naringenin; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: endothelial plasminogen activator inhibitor; PAI; PAI-1; Pai1; PAI1A; Pai1aa; Planh; Plasminogen activator inhibitor; plasminogen activator inhibitor 1; RATPAI1A; serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, member 1; serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,237,977 - 25,248,356 (+)NCBIGRCr8
mRatBN7.21219,601,272 - 19,611,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,601,272 - 19,611,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,739,113 - 20,749,506 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,351,819 - 21,362,213 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,416,358 - 20,426,756 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,641,104 - 22,651,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,641,104 - 22,651,482 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,653,385 - 24,663,763 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,931,996 - 20,942,374 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11220,921,607 - 20,931,986 (-)NCBI
Celera1221,377,028 - 21,387,410 (+)NCBICelera
RH 3.4 Map12277.5RGD
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IMP)
Acquired Protein C Deficiency  (IEP)
Acute Lung Injury  (IDA,IEP)
acute necrotizing pancreatitis  (IEP,ISO)
adult respiratory distress syndrome  (ISO)
Aggressive Fibromatosis  (ISO)
Albuminuria  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic rhinitis  (ISO)
amyloidosis  (ISO)
Animal Disease Models  (ISO)
anterolateral myocardial infarction  (ISO)
aortic aneurysm  (IMP)
Aortic Remodeling  (IDA)
Arterial Thrombosis  (IEP)
asthma  (IEP,ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
bacterial pneumonia  (ISO)
Banti's Syndrome  (ISO)
Behcet's disease  (ISO)
Brain Hypoxia-Ischemia  (ISO)
brain ischemia  (IDA)
breast cancer  (ISO)
bronchopulmonary dysplasia  (ISO)
Cardiac Fibrosis  (IDA,IEP)
Carotid Artery Injuries  (IEP)
Central Serous Chorioretinopathy  (ISO)
cerebral infarction  (IDA)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Choroidal Neovascularization, Experimental  (IDA,ISO)
Chronic Allograft Nephropathy  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
Chronic Relapsing Experimental Autoimmune Encephalomyelitis  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronavirus infectious disease  (ISS)
Dermal Fibrosis  (ISO)
diabetes mellitus  (IDA)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (IDA,IEP,ISO)
diabetic retinopathy  (ISO)
disseminated intravascular coagulation  (IDA,IEP)
end stage renal disease  (IDA,ISO)
Endotoxemia  (IDA,IEP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial combined hyperlipidemia  (ISO)
familial hypercholesterolemia  (ISO)
familial Mediterranean fever  (ISO)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
fibrosarcoma  (ISO)
focal segmental glomerulosclerosis  (IEP,ISO)
Gastrointestinal Hemorrhage  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (IDA,IEP)
graft-versus-host disease  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
hematopoietic system disease  (IDA)
Hemorrhage  (IDA,IEP,ISO)
hemorrhagic disease  (ISO)
high grade glioma  (ISO)
Hyaline Membrane Disease  (ISO)
hypertension  (IDA,IEP,ISO)
hyperthyroidism  (ISO)
Insulin Resistance  (IDA,IEP)
interstitial lung disease  (ISO)
Intestinal Polyps  (ISO)
Intestinal Reperfusion Injury  (IDA)
ischemic colitis  (ISO)
Kidney Reperfusion Injury  (ISO)
limited scleroderma  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Liver Reperfusion Injury  (IEP)
lung disease  (ISO)
Lung Reperfusion Injury  (IDA,ISO)
macular degeneration  (ISO)
metabolic dysfunction and alcohol associated liver disease  (IEP)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (IDA)
middle cerebral artery infarction  (IEP)
Multiple Organ Failure  (IDA)
Multiple Trauma  (IEP)
muscular atrophy  (IEP)
myocardial infarction  (IMP,ISO)
Myocardial Reperfusion Injury  (IDA)
Neointima  (IMP,ISO)
Neovascularization, Pathologic  (ISO)
nephrotic syndrome  (ISO)
nervous system disease  (ISO)
neurilemmoma  (ISO)
Noonan syndrome  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
Oxygen-Induced Retinopathy  (IEP,ISO)
Penetrating Wounds  (IEP)
peripheral artery disease  (ISO)
Peritoneal Adhesions  (IDA,IEP)
Peritoneal Fibrosis  (ISO)
placental insufficiency  (ISO)
Plasminogen Activator Inhibitor-1 Deficiency  (ISO)
platelet-type bleeding disorder 10  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
pleurisy  (ISO)
pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
polycythemia  (IEP)
polyneuropathy  (ISO)
portal vein thrombosis  (ISO)
Postoperative Atrial Fibrillation  (ISO)
pre-eclampsia  (ISO)
Pregnancy Complications  (ISO)
proliferative diabetic retinopathy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (IEP,IMP,ISO)
pulmonary hypertension  (IDA,ISO)
Radiation Nephropathy  (IEP)
relapsing-remitting multiple sclerosis  (ISO)
renal fibrosis  (IDA,IEP)
respiratory allergy  (ISO)
retinal vein occlusion  (ISO)
retinopathy of prematurity  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (IDA)
Sepsis  (IDA,ISO)
sleep apnea  (ISO)
steatotic liver disease  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Sudden Hearing Loss  (ISO)
systemic scleroderma  (ISO)
thoracic aortic aneurysm  (ISO)
thrombosis  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (IDA)
type 2 diabetes mellitus  (IDA,IEP,ISO)
ureteral obstruction  (IDA,IEP,ISO)
urinary bladder cancer  (ISO)
uveal melanoma  (ISO)
Vascular Depression  (IDA)
Vascular Remodeling  (ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (IEP,IMP,ISO)
Ventilator-Induced Lung Injury  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(R)-adrenaline  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(S)-colchicine  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dichlorophenol  (ISO)
2,5-dichlorophenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-butoxyethanol  (ISO)
2-chloroethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4'-Methoxychalcone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminophenol  (EXP)
4-hydroxy-TEMPO  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrolein  (EXP,ISO)
adenine  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
aminoguanidine  (EXP,ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (ISO)
apocynin  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspalathin  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP,ISO)
Aurin  (ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
barium chloride  (EXP)
benazepril  (EXP,ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (EXP)
busulfan  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium selenide  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camostat  (EXP)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
chenodeoxycholic acid  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciglitazone  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
Clofop  (ISO)
clothianidin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
daunorubicin  (EXP,ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
dienogest  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dinitrogen  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
emodin  (ISO)
enalapril  (EXP)
enalaprilat dihydrate  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
eplerenone  (EXP)
eprosartan  (EXP)
Ethyl icosapentate  (EXP)
ethyl methanesulfonate  (ISO)
famotidine  (EXP)
fenofibrate  (EXP,ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fosinopril  (EXP)
fructose  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
geldanamycin  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
gestodene  (ISO)
Gingerenone A  (ISO)
glucose  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
Goe 6976  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
guanethidine  (ISO)
GW 501516  (ISO)
heparin  (EXP)
hexadecanoic acid  (ISO)
Hexadimethrine bromide  (EXP)
Honokiol  (EXP)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroxychloroquine  (ISO)
hydroxyl  (ISO)
hypochlorous acid  (ISO)
indirubin-3'-monoxime  (ISO)
indometacin  (ISO)
ionomycin  (EXP)
iron(III) citrate  (ISO)
isobutanol  (ISO)
isoprenaline  (EXP)
isorhamnetin  (ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
kainic acid  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
levonorgestrel  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
magnesium atom  (ISO)
magnesium dichloride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (EXP)
Mecamylamine  (ISO)
medroxyprogesterone acetate  (ISO)
meglumine amidotrizoate  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
metaproterenol  (EXP)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metyrapone  (EXP)
mifepristone  (EXP,ISO)
mitomycin C  (ISO)
mitoxantrone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
Muraglitazar  (EXP)
N-acetylsphingosine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naphthalenes  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP,ISO)
nonanedioic acid  (ISO)
Nonidet P-40  (ISO)
norethisterone  (ISO)
notoginsenoside R1  (ISO)
NSC 23766  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
octadecanoic acid  (ISO)
oleic acid  (ISO)
Olmesartan medoxomil  (EXP)
orciprenaline  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
pazopanib  (ISO)
pentane-2,3-dione  (EXP)
Pentoxifylline  (EXP)
perfluorobutyric acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoropentanoic acid  (ISO)
Phenelzine  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phentolamine  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
phosphane  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
Phytolaccoside E  (ISO)
pioglitazone  (EXP,ISO)
pirfenidone  (EXP,ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
potassium chloride  (EXP)
potassium dichromate  (ISO)
procyanidin B3  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
reserpine  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
roflumilast  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salvianolic acid B  (ISO)
saralasin  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sotorasib  (ISO)
spironolactone  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
superoxide  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tartrazine  (ISO)
taurocholic acid  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiacloprid  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
thiram  (ISO)
tibolone  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP,ISO)
trametinib  (ISO)
trans-caffeic acid  (ISO)
triadimefon  (ISO)
triamterene  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
undecane  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vincaleukoblastine  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin E  (EXP)
wortmannin  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc molecular entity  (ISO)
zinc oxide  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (EXP,ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
cellular response to aldosterone  (IEP)
cellular response to angiotensin  (IEP)
cellular response to ATP  (IEP)
cellular response to cAMP  (IEP)
cellular response to cGMP  (IEP)
cellular response to cycloheximide  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to glucagon stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to gravity  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to hypoxia  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to interleukin-1  (IDA)
cellular response to leukemia inhibitory factor  (IEP)
cellular response to lipopolysaccharide  (IEA,IEP,ISO)
cellular response to low-density lipoprotein particle stimulus  (IEP)
cellular response to mechanical stimulus  (IEP)
cellular response to metal ion  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to nicotine  (IEP)
cellular response to organic cyclic compound  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular response to potassium ion  (IEP)
cellular response to resveratrol  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP,ISO)
cellular response to xenobiotic stimulus  (IDA)
decidualization  (IEP)
defense response to Gram-negative bacterium  (IEA,ISO)
dentinogenesis  (IEA,ISO)
female gonad development  (IDA)
mast cell activation  (IEP)
negative regulation of cell adhesion mediated by integrin  (IEA,ISO)
negative regulation of cell migration  (IDA,IMP,ISO)
negative regulation of endopeptidase activity  (IC,IDA,ISO)
negative regulation of endothelial cell apoptotic process  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
negative regulation of fibrinolysis  (IEA,ISO)
negative regulation of gene expression  (IMP)
negative regulation of plasminogen activation  (IBA,IEA,ISO)
negative regulation of smooth muscle cell migration  (IEA,ISO)
negative regulation of smooth muscle cell-matrix adhesion  (IEA,ISO)
negative regulation of vascular wound healing  (IBA,IEA,ISO)
placenta development  (ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of blood coagulation  (ISO)
positive regulation of calcium ion import  (IMP)
positive regulation of coagulation  (IMP)
positive regulation of collagen biosynthetic process  (IMP)
positive regulation of epithelium regeneration  (IMP)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of keratinocyte migration  (IMP)
positive regulation of leukotriene production involved in inflammatory response  (IEA,ISO)
positive regulation of monocyte chemotaxis  (IEA,ISO)
positive regulation of odontoblast differentiation  (IEA,ISO)
positive regulation of receptor-mediated endocytosis  (IEA,IMP,ISO)
regulation of angiogenesis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of signaling receptor activity  (ISO)
replicative senescence  (IEA,ISO,ISS)
response to cytokine  (IEP)
response to epidermal growth factor  (IEP)
response to estrogen  (IEP)
response to hyperoxia  (IEP)
response to laminar fluid shear stress  (IEP)
response to lipopolysaccharide  (IEP)
response to nutrient levels  (IEP)
response to reactive oxygen species  (IEP)
response to starvation  (IEP)
response to transforming growth factor beta  (IEP)
tissue regeneration  (IEP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
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79. Interleukin-1-mediated regulation of plasminogen activation in pregnant mare serum gonadotropin-primed rat granulosa cells is independent of prostaglandin production. Hurwitz A, etal., J Soc Gynecol Investig. 1995 Sep-Oct;2(5):691-9.
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83. Plasminogen activator inhibitor-1 and tissue-type plasminogen activator are up-regulated during unilateral ureteral obstruction in adult rats. Ishidoya S, etal., J Urol. 2002 Mar;167(3):1503-7.
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86. Effects of activated protein C on ventilator-induced lung injury in rats. Jiang JS, etal., Respiration. 2010;80(3):246-53. Epub 2010 Jan 28.
87. The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles. Jiang Q, etal., Blood. 2011 Jun 30;117(26):7155-63. doi: 10.1182/blood-2010-05-287672. Epub 2011 May 19.
88. Low-dose paclitaxel ameliorates renal fibrosis by suppressing transforming growth factor-beta1-induced plasminogen activator inhibitor-1 signaling. Jung ES, etal., Nephrology (Carlton). 2016 Feb 11. doi: 10.1111/nep.12747.
89. The mRNA expressions and immunohistochemistry of factors involved in angiogenesis and lymphangiogenesis in the early stage of rat skin incision wounds. Kameyama H, etal., Leg Med (Tokyo). 2015 Jul;17(4):255-60. doi: 10.1016/j.legalmed.2015.02.007. Epub 2015 Mar 7.
90. Endothelial haemostatic markers in members of families with familial combined hyperlipidemia. Karásek D, etal., Thromb Res. 2009;123(3):466-75. doi: 10.1016/j.thromres.2008.02.011. Epub 2008 Apr 16.
91. t-plasminogen activator inhibitor-1 polymorphism in idiopathic pulmonary arterial hypertension. Katta S, etal., Indian J Hum Genet. 2008 May;14(2):37-40.
92. Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens. Kelly LA, etal., Thromb Haemost. 2010 Sep 13;104(6).
93. Renal synthesis of urokinase type-plasminogen activator, its receptor, and plasminogen activator inhibitor-1 in diabetic nephropathy in rats: modulation by angiotensin-converting-enzyme inhibitor. Kenichi M, etal., J Lab Clin Med. 2004 Aug;144(2):69-77.
94. Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes. Kietzmann T, etal., Blood 2003 Feb 1;101(3):907-14.
95. Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes. Kietzmann T, etal., Blood. 1999 Dec 15;94(12):4177-85.
96. Regulation of the hypoxia-dependent plasminogen activator inhibitor 1 expression by MAP kinases. Kietzmann T, etal., Thromb Haemost. 2003 Apr;89(4):666-73.
97. A plasminogen activator inhibitor-1 promoter polymorphism and idiopathic interstitial pneumonia. Kim KK, etal., Mol Med. 2003 Jan-Feb;9(1-2):52-6.
98. Polymorphisms of angiotensin converting enzyme and plasminogen activator inhibitor-1 genes in diabetes and macroangiopathy1. Kimura H, etal., Kidney Int. 1998 Nov;54(5):1659-69.
99. Involvement of Rho-kinase pathway for angiotensin II-induced plasminogen activator inhibitor-1 gene expression and cardiovascular remodeling in hypertensive rats. Kobayashi N, etal., J Pharmacol Exp Ther. 2002 May;301(2):459-66.
100. A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis. Komiya Y, etal., J Biol Chem. 2008 Jul 4;283(27):18753-64. Epub 2008 May 5.
101. Plasminogen activator inhibitor type 1 inhibits smooth muscle cell proliferation in pulmonary arterial hypertension. Kouri FM, etal., Int J Biochem Cell Biol. 2008;40(9):1872-82. Epub 2008 Feb 2.
102. Plasmin system regulation in an ovalbumin-induced rat model of asthma. Kucharewicz I, etal., Int Arch Allergy Immunol. 2008;147(3):190-6. Epub 2008 Jul 2.
103. In vivo anticoagulant effect of ethyl pyruvate in endotoxemic rats. Kung CW, etal., Thromb Res. 2011 Jun;127(6):582-8. Epub 2011 Mar 10.
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Additional References at PubMed
PMID:1601887   PMID:1632457   PMID:1695900   PMID:2298740   PMID:2503541   PMID:8508955   PMID:8837777   PMID:9207454   PMID:9386191   PMID:10902815   PMID:11776323   PMID:11818362  
PMID:11866539   PMID:12114510   PMID:12192306   PMID:12600825   PMID:12777947   PMID:14610081   PMID:15201552   PMID:15328353   PMID:15728787   PMID:15808835   PMID:15853774   PMID:16862142  
PMID:17394767   PMID:17396111   PMID:17655862   PMID:17953365   PMID:18367662   PMID:18471418   PMID:18554148   PMID:18636553   PMID:18664599   PMID:18761555   PMID:18835034   PMID:18974388  
PMID:19246637   PMID:19306296   PMID:19403340   PMID:19625379   PMID:19718486   PMID:19855083   PMID:19887897   PMID:19916862   PMID:20538356   PMID:21036181   PMID:21119013   PMID:21193004  
PMID:21276792   PMID:21355198   PMID:21412817   PMID:21613793   PMID:21752621   PMID:21829547   PMID:22071631   PMID:22556277   PMID:23016136   PMID:23021499   PMID:23218127   PMID:23979707  
PMID:24006456   PMID:24913911   PMID:25106729   PMID:25342286   PMID:26415098   PMID:27046084   PMID:27456456   PMID:28337441   PMID:28722352   PMID:29644896   PMID:30449218   PMID:30982977  
PMID:31257474   PMID:32748313   PMID:33450132   PMID:35352799  


Genomics

Comparative Map Data
Serpine1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,237,977 - 25,248,356 (+)NCBIGRCr8
mRatBN7.21219,601,272 - 19,611,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,601,272 - 19,611,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,739,113 - 20,749,506 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,351,819 - 21,362,213 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,416,358 - 20,426,756 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,641,104 - 22,651,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,641,104 - 22,651,482 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,653,385 - 24,663,763 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,931,996 - 20,942,374 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11220,921,607 - 20,931,986 (-)NCBI
Celera1221,377,028 - 21,387,410 (+)NCBICelera
RH 3.4 Map12277.5RGD
Cytogenetic Map12q12NCBI
SERPINE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387101,127,104 - 101,139,247 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7101,127,104 - 101,139,247 (+)EnsemblGRCh38hg38GRCh38
GRCh377100,770,385 - 100,782,528 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,557,172 - 100,569,026 (+)NCBINCBI36Build 36hg18NCBI36
Build 347100,363,886 - 100,375,741NCBI
Celera795,778,744 - 95,790,926 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef795,363,553 - 95,375,745 (+)NCBIHuRef
CHM1_17100,700,705 - 100,712,867 (+)NCBICHM1_1
T2T-CHM13v2.07102,449,908 - 102,462,056 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27100,128,757 - 100,140,934 (+)NCBI
Serpine1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,090,358 - 137,101,126 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,090,358 - 137,101,122 (-)EnsemblGRCm39 Ensembl
GRCm385137,061,504 - 137,072,272 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,061,504 - 137,072,268 (-)EnsemblGRCm38mm10GRCm38
MGSCv375137,537,374 - 137,548,142 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,346,135 - 137,356,886 (-)NCBIMGSCv36mm8
Celera5134,078,340 - 134,089,224 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.16NCBI
Serpine1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545616,145,944 - 16,157,142 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545616,147,523 - 16,157,040 (-)NCBIChiLan1.0ChiLan1.0
SERPINE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26119,139,033 - 119,151,584 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17167,403,992 - 167,416,224 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0793,267,517 - 93,279,728 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,511,539 - 106,518,605 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,510,130 - 106,518,450 (+)Ensemblpanpan1.1panPan2
SERPINE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,719,547 - 8,727,160 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,720,825 - 8,726,301 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,418,147 - 10,423,482 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.068,538,810 - 8,546,429 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,540,391 - 8,550,490 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,500,159 - 8,505,509 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,470,611 - 8,475,963 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.068,635,341 - 8,640,693 (-)NCBIUU_Cfam_GSD_1.0
Serpine1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344132,997,052 - 133,003,714 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365431,032,794 - 1,039,123 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365431,032,543 - 1,040,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,863,695 - 8,871,547 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,863,738 - 8,871,572 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SERPINE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,047,520 - 12,060,662 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,047,529 - 12,060,202 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660704,295,672 - 4,308,796 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpine1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,128,059 - 16,137,337 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,128,145 - 16,136,696 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Serpine1
61 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:814
Count of miRNA genes:305
Interacting mature miRNAs:394
Transcripts:ENSRNOT00000001916
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat

Markers in Region
D12Mit2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,610,870 - 19,611,091 (+)MAPPERmRatBN7.2
Rnor_6.01222,650,702 - 22,650,918NCBIRnor6.0
Rnor_5.01224,662,983 - 24,663,199UniSTSRnor5.0
RGSC_v3.41220,932,560 - 20,932,776UniSTSRGSC3.4
RGSC_v3.41220,932,559 - 20,932,776RGDRGSC3.4
RGSC_v3.11220,922,171 - 20,922,388RGD
Celera1221,386,630 - 21,386,846UniSTS
RH 3.4 Map12280.3RGD
RH 3.4 Map12280.3UniSTS
RH 2.0 Map12205.1RGD
SHRSP x BN Map1222.7RGD
FHH x ACI Map129.01RGD
Cytogenetic Map12q11-q12UniSTS
D12Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,610,886 - 19,611,090 (+)MAPPERmRatBN7.2
Rnor_6.01222,650,718 - 22,650,917NCBIRnor6.0
Rnor_5.01224,662,999 - 24,663,198UniSTSRnor5.0
RGSC_v3.41220,932,561 - 20,932,760UniSTSRGSC3.4
RGSC_v3.41220,932,560 - 20,932,760RGDRGSC3.4
RGSC_v3.11220,922,172 - 20,922,372RGD
Celera1221,386,646 - 21,386,845UniSTS
RH 3.4 Map12277.7UniSTS
RH 3.4 Map12277.7RGD
RH 2.0 Map12206.8RGD
Cytogenetic Map12q11-q12UniSTS
D12Wox12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,610,889 - 19,611,095 (+)MAPPERmRatBN7.2
Rnor_6.01222,650,721 - 22,650,922NCBIRnor6.0
Rnor_5.01224,663,002 - 24,663,203UniSTSRnor5.0
RGSC_v3.41220,932,556 - 20,932,757UniSTSRGSC3.4
RGSC_v3.41220,932,555 - 20,932,757RGDRGSC3.4
RGSC_v3.11220,922,167 - 20,922,369RGD
Celera1221,386,649 - 21,386,850UniSTS
RH 3.4 Map12277.5UniSTS
RH 3.4 Map12277.5RGD
RH 2.0 Map12197.1RGD
Cytogenetic Map12q11-q12UniSTS
D12Arb4   No map positions available.
RH129692  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,611,385 - 19,611,585 (+)MAPPERmRatBN7.2
Rnor_6.01222,651,211 - 22,651,410NCBIRnor6.0
Rnor_5.01224,663,492 - 24,663,691UniSTSRnor5.0
RGSC_v3.41220,932,068 - 20,932,267UniSTSRGSC3.4
Celera1221,387,139 - 21,387,338UniSTS
RH 3.4 Map12277.5UniSTS
Cytogenetic Map12q11-q12UniSTS
RH142420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,610,381 - 19,610,594 (+)MAPPERmRatBN7.2
Rnor_6.01222,650,213 - 22,650,425NCBIRnor6.0
Rnor_5.01224,662,494 - 24,662,706UniSTSRnor5.0
RGSC_v3.41220,933,053 - 20,933,265UniSTSRGSC3.4
Celera1221,386,141 - 21,386,353UniSTS
RH 3.4 Map12277.5UniSTS
Cytogenetic Map12q11-q12UniSTS
RH94577  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,611,229 - 19,611,407 (+)MAPPERmRatBN7.2
Rnor_6.01222,651,055 - 22,651,232NCBIRnor6.0
Rnor_5.01224,663,336 - 24,663,513UniSTSRnor5.0
RGSC_v3.41220,932,246 - 20,932,423UniSTSRGSC3.4
Celera1221,386,983 - 21,387,160UniSTS
Cytogenetic Map12q11-q12UniSTS
PMC15197P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,609,566 - 19,610,072 (+)MAPPERmRatBN7.2
Rnor_6.01222,649,398 - 22,649,903NCBIRnor6.0
Rnor_5.01224,661,679 - 24,662,184UniSTSRnor5.0
RGSC_v3.41220,933,575 - 20,934,080UniSTSRGSC3.4
Celera1221,385,326 - 21,385,831UniSTS
Cytogenetic Map12q11-q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000001916   ⟹   ENSRNOP00000001916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,601,272 - 19,611,657 (+)Ensembl
Rnor_6.0 Ensembl1222,641,104 - 22,651,482 (+)Ensembl
RefSeq Acc Id: NM_012620   ⟹   NP_036752
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,237,977 - 25,248,356 (+)NCBI
mRatBN7.21219,601,272 - 19,611,657 (+)NCBI
Rnor_6.01222,641,104 - 22,651,482 (+)NCBI
Rnor_5.01224,653,385 - 24,663,763 (+)NCBI
RGSC_v3.41220,931,996 - 20,942,374 (-)RGD
Celera1221,377,028 - 21,387,410 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036752 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41796 (Get FASTA)   NCBI Sequence Viewer  
  AAA56856 (Get FASTA)   NCBI Sequence Viewer  
  EDM13286 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001916.2
  ENSRNOP00055000151
  ENSRNOP00060016231
  ENSRNOP00065001504
GenBank Protein P20961 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036752   ⟸   NM_012620
- Peptide Label: precursor
- UniProtKB: P20961 (UniProtKB/Swiss-Prot),   F1LM16 (UniProtKB/TrEMBL),   A6J047 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001916   ⟸   ENSRNOT00000001916
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20961-F1-model_v2 AlphaFold P20961 1-402 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698524
Promoter ID:EPDNEW_R9049
Type:multiple initiation site
Name:Serpine1_1
Description:serpin family E member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,641,079 - 22,641,139EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3249 AgrOrtholog
BioCyc Gene G2FUF-19678 BioCyc
Ensembl Genes ENSRNOG00000001414 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055000166 UniProtKB/Swiss-Prot
  ENSRNOG00060012143 UniProtKB/Swiss-Prot
  ENSRNOG00065001606 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001916.3 UniProtKB/TrEMBL
  ENSRNOT00055000256 UniProtKB/Swiss-Prot
  ENSRNOT00060020611 UniProtKB/Swiss-Prot
  ENSRNOT00065002155 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24617 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24617 ENTREZGENE
PANTHER PLASMINOGEN ACTIVATOR INHIBITOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SERPINE1 RGD
PhenoGen Serpine1 PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001414 RatGTEx
  ENSRNOG00055000166 RatGTEx
  ENSRNOG00060012143 RatGTEx
  ENSRNOG00065001606 RatGTEx
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6J047 ENTREZGENE, UniProtKB/TrEMBL
  F1LM16 ENTREZGENE, UniProtKB/TrEMBL
  P20961 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpine1  serpin family E member 1  Serpine1  serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-01-19 Serpine1  serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1  Serpine1  serine (or cysteine) peptidase inhibitor, clade E, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Serpine1  serine (or cysteine) peptidase inhibitor, clade E, member 1    serine (or cysteine) proteinase inhibitor, clade E, member 1  Name updated 1299863 APPROVED
2004-12-14 Serpine1  serine (or cysteine) proteinase inhibitor, clade E, member 1    serine (or cysteine) proteinase inhibitor, member 1  Name updated 1299863 APPROVED
2003-05-08 Serpine1  serine (or cysteine) proteinase inhibitor, member 1      Symbol and Name updated to reflect Human and Mouse nomenclature 61478 PROVISIONAL
2002-06-10 Pai1  serine (or cysteine) proteinase inhibitor, member 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression induced during hepatocyte regeneration after liver injury 70249
gene_expression found in plasma and platelets and in endothelial, hepatoma, and fibrosarcoma cells 61489
gene_physical_interaction interacts with tissue plasminogen activator, urokinase, and protein c  
gene_process may function as a major control point in the regulation of fibrinolysis  
gene_product acid-stable glycoprotein 61489