Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3249
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpine1
Name: serpin family E member 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpine1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of SERPINE1 mRNAPMID:20211217 PMID:23558518
Serpine1affects expressionISOSERPINE1 (Homo sapiens)6480464CTDDoxorubicin affects the expression of SERPINE1 mRNAPMID:29803840
Serpine1affects response to substanceISOSERPINE1 (Homo sapiens)6480464CTDSERPINE1 protein affects the susceptibility to DoxorubicinPMID:16217747
Serpine1decreases expressionISOSERPINE1 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of SERPINE1 mRNAPMID:16705698
Serpine1increases expressionISOSerpine1 (Mus musculus)6480464CTDDoxorubicin results in increased expression of SERPINE1 mRNAPMID:21040762 PMID:25896364 PMID:28318631 PMID:36227756
Serpine1increases expressionISOSERPINE1 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of SERPINE1 mRNAPMID:15870702 PMID:30031762
Serpine1multiple interactionsISOSerpine1 (Mus musculus)6480464CTD[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of SERPINE1 mRNA; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of SERPINE1 mRNA]PMID:21040762 PMID:28318631
Go Back to source page   Continue to Ontology report