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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3249
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpine1
Name: serpin family E member 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpine1decreases response to substanceEXP 6480464CTDSERPINE1 protein results in decreased susceptibility to Valproic AcidPMID:23378038
Serpine1multiple interactionsEXP 6480464CTD[Valproic Acid results in decreased activity of SERPINE1 protein] which results in increased activity of PLAT protein; pyrazolanthrone inhibits the reaction [Valproic Acid results in decreased activity of and results in decreased secretion of SERPINE1 protein]; SERPINE1 protein inhibits the reaction [Valproic Acid results in increased activity of PLAT protein]; Valproic Acid results in decreased activity of and results in decreased secretion of SERPINE1 proteinPMID:23378038
Serpine1affects expressionISOSERPINE1 (Homo sapiens)6480464CTDValproic Acid affects the expression of SERPINE1 mRNAPMID:25979313
Serpine1decreases methylationISOSERPINE1 (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of SERPINE1 genePMID:29154799
Serpine1increases expressionISOSERPINE1 (Homo sapiens)6480464CTDValproic Acid results in increased expression of SERPINE1 mRNAPMID:23179753 PMID:24935251 PMID:26272509 PMID:26705709 PMID:28001369
Serpine1increases response to substanceISOSerpine1 (Mus musculus)6480464CTDSERPINE1 gene mutant form results in increased susceptibility to Valproic AcidPMID:23378038
Serpine1multiple interactionsISOSERPINE1 (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNAPMID:27188386
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