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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3249
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpine1
Name: serpin family E member 1
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpine1affects expressionEXP 6480464CTDFenofibrate affects the expression of SERPINE1 mRNAPMID:20801182
Serpine1multiple interactionsEXP 6480464CTD[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of SERPINE1 mRNAPMID:18253720
Serpine1multiple interactionsISOSerpine1 (Mus musculus)6480464CTDFenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]]PMID:19593819
Serpine1multiple interactionsISOSERPINE1 (Homo sapiens)6480464CTDFenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]]PMID:19593819
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