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GENE - TERM ANNOTATION REPORT

RGD ID: 3249
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpine1
Name: serpin family E member 1
Acc ID: DOID:8947
Term: diabetic retinopathy
Definition: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
Definition Source(s): MESH:D003930
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpine1 ISOSERPINE1 (Homo sapiens)8547710RGDassociated with Diabetes Mellitus, Type 1;protein:increased expression:plasma (human) 
Serpine1no_associationISOSERPINE1 (Homo sapiens)8547699RGDassociated with Diabetes Mellitus, Type 2;DNA:deletion:promoter:g.-676_-674delG (human) 
Serpine1no_associationISOSERPINE1 (Homo sapiens)8547740RGDassociated with Diabetes Mellitus;repeat, snp:intron, 3' utr:g.7844(CA)1-6, ? (human) 
Serpine1susceptibilityISOSERPINE1 (Homo sapiens)8547697RGDassociated with Diabetes Mellitus, Type 2;DNA:deletion:promoter:g.-676_-674delG (human) 
Serpine1susceptibilityISOSERPINE1 (Homo sapiens)8547741RGDassociated with Diabetes Mellitus, Type 2;DNA:snp, deletion:promoter:g.-844G>A, g.-676_-674delG (human) 
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