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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3249
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpine1
Name: serpin family E member 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpine1increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of SERPINE1 mRNAPMID:31734849
Serpine1decreases expressionISOSERPINE1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of SERPINE1 mRNAPMID:17530438
Serpine1increases expressionISOSERPINE1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of SERPINE1 mRNAPMID:26705709 PMID:31734849
Serpine1multiple interactionsISOSERPINE1 (Homo sapiens)6480464CTDArsenic Trioxide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]PMID:24762191
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