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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3249
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpine1
Name: serpin family E member 1
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpine1decreases expressionEXP 6480464CTDSimvastatin results in decreased expression of SERPINE1 mRNAPMID:16414398
Serpine1decreases activityISOSERPINE1 (Homo sapiens)6480464CTDSimvastatin results in decreased activity of SERPINE1 proteinPMID:17513194
Serpine1decreases expressionISOSERPINE1 (Homo sapiens)6480464CTDSimvastatin results in decreased expression of SERPINE1 mRNA; Simvastatin results in decreased expression of SERPINE1 proteinPMID:16375908 PMID:17513194 PMID:21524281
Serpine1decreases secretionISOSERPINE1 (Homo sapiens)6480464CTDSimvastatin results in decreased secretion of SERPINE1 proteinPMID:21524281
Serpine1multiple interactionsISOSERPINE1 (Homo sapiens)6480464CTD[Simvastatin co-treated with Dexamethasone] results in increased secretion of SERPINE1 proteinPMID:21524281
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