GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Serpine1 | decreases expression | ISO | SERPINE1 (Homo sapiens) | 6480464 | CTD | Cannabidiol results in decreased expression of SERPINE1 mRNA | PMID:20668920 | Serpine1 | decreases secretion | ISO | SERPINE1 (Homo sapiens) | 6480464 | CTD | Cannabidiol results in decreased secretion of SERPINE1 protein | PMID:20668920 | Serpine1 | increases expression | ISO | Serpine1 (Mus musculus) | 6480464 | CTD | Cannabidiol analog results in increased expression of SERPINE1 protein | PMID:30382123 | Serpine1 | increases response to substance | ISO | SERPINE1 (Homo sapiens) | 6480464 | CTD | SERPINE1 protein results in increased susceptibility to Cannabidiol | PMID:20668920 | Serpine1 | multiple interactions | ISO | Serpine1 (Mus musculus) | 6480464 | CTD | Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of SERPINE1 protein]; Cannabidiol analog promotes the reaction [Dietary Fats results in increased expression of SERPINE1 protein] | PMID:30382123 PMID:30825431 | Serpine1 | multiple interactions | ISO | SERPINE1 (Homo sapiens) | 6480464 | CTD | Cannabidiol inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; CNR1 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein]; CNR2 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein]; TRPV1 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein] | PMID:20668920 PMID:31250491 | |
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