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ONTOLOGY REPORT - ANNOTATIONS

Term:RISC complex
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Accession:GO:0016442 term browser browse the term
Definition:A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
Synonyms:exact_synonym: RNA-induced silencing complex
 related_synonym: miRNP complex;   micro-ribonucleoprotein complex
 alt_id: GO:0035068
 xref: Wikipedia:RNA-induced_silencing_complex
 never_in_taxon: NCBITaxon:4896 ! Schizosaccharomyces pombe


show annotations for term's descendants           Sort by:
RISC complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago1 argonaute RISC component 1 part_of ISO
IBA		 (PMID:15260970), (PMID:17932509), (PMID:19966796)
(PMID:19536157)
GO_REF:0000033		 RGD
GO_Central		 PMID:15260970 PMID:17932509 PMID:19536157 PMID:19966796 GO_REF:0000033 NCBI chr 5:138,722,111...138,757,118
Ensembl chr 5:138,722,111...138,773,546 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 part_of ISS
ISO
IDA
IBA
IEA		 GO_REF:0000024
RNAcentral:URS000034B6F5_9606|RNAcentral:URS00005416E3_9606|RNAcentral:URS000055128B_9606 (PMID:15260970), (PMID:17531811), (PMID:17671087), (PMID:17932509), (PMID:19701182), (PMID:19826008), (PMID:19966796), (PMID:20616046), (PMID:31012336), (PMID:31507089)
MMO:0000683
GO_REF:0000033
GO_REF:0000117
(PMID:16357216), (PMID:19536157), (PMID:20424607), (PMID:22503104)		 UniProt
RGD
GO_Central		 PMID:15260970 PMID:16357216 PMID:17531811 PMID:17671087 PMID:17932509 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000117, RGD:401900732 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 part_of ISO
IBA		 (PMID:15260970), (PMID:19966796)
(PMID:19536157)
GO_REF:0000033		 RGD
GO_Central		 PMID:15260970 PMID:19536157 PMID:19966796 GO_REF:0000033 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230 		JBrowse link
G Ago4 argonaute RISC component 4 part_of ISO
IBA		 (PMID:15260970), (PMID:19966796)
(PMID:19536157)
GO_REF:0000033		 RGD
GO_Central		 PMID:15260970 PMID:19536157 PMID:19966796 GO_REF:0000033 NCBI chr 5:138,780,446...138,825,898
Ensembl chr 5:138,783,069...138,825,632 		JBrowse link
G Dcp2 decapping mRNA 2 part_of ISO (PMID:20616046) RGD PMID:20616046 NCBI chr18:36,750,732...36,787,067
Ensembl chr18:36,750,732...36,788,557 		JBrowse link
G Ddx6 DEAD-box helicase 6 part_of ISO (PMID:20616046) RGD PMID:20616046 NCBI chr 8:44,931,127...44,967,773
Ensembl chr 8:44,931,974...44,964,405 		JBrowse link
G Dhx9 DExH-box helicase 9 part_of ISO (PMID:17531811) RGD PMID:17531811 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069 		JBrowse link
G Dicer1 dicer 1 ribonuclease III NOT|part_of ISO (PMID:16357216)
(PMID:17531811)
(PMID:22503104)		 RGD PMID:16357216 PMID:17531811 PMID:22503104 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E part_of ISO (PMID:20616046) RGD PMID:20616046 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Limd1 LIM domain containing 1 part_of ISO (PMID:20616046) RGD PMID:20616046 NCBI chr 8:123,121,363...123,168,476
Ensembl chr 8:123,122,460...123,167,714 		JBrowse link
G Mir1 microRNA 1 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr18:1,887,537...1,887,623 JBrowse link
G Mir101-2 microRNA 101-2 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 1:226,860,371...226,860,467
Ensembl chr 1:226,860,371...226,860,467 		JBrowse link
G Mir101a microRNA 101a part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410 		JBrowse link
G Mir106a microRNA 106a part_of ISO (PMID:24205035) RGD PMID:24205035 NCBI chr  X:132,422,584...132,422,661
Ensembl chr  X:132,422,584...132,422,661 		JBrowse link
G Mir106b microRNA 106b part_of ISO (PMID:23185045), (PMID:24205035) RGD PMID:23185045 PMID:24205035 NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425 		JBrowse link
G Mir122 microRNA 122 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir124-1 microRNA 124-1 part_of ISO (PMID:19515986) RGD PMID:19515986 NCBI chr15:38,842,014...38,842,098
Ensembl chr15:38,842,014...38,842,098 		JBrowse link
G Mir124-2 microRNA 124-2 part_of ISO (PMID:19536157) RGD PMID:19536157 NCBI chr 2:100,134,866...100,134,974
Ensembl chr 2:100,134,866...100,134,974 		JBrowse link
G Mir124-3 microRNA 124-3 part_of ISO (PMID:19536157) RGD PMID:19536157 NCBI chr 3:168,014,952...168,015,038
Ensembl chr 3:168,014,952...168,015,038 		JBrowse link
G Mir139 microRNA 139 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 1:155,878,828...155,878,895
Ensembl chr 1:155,878,825...155,878,902 		JBrowse link
G Mir140 microRNA 140 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675 		JBrowse link
G Mir144 microRNA 144 part_of ISO (PMID:20424607), (PMID:23185045) RGD PMID:20424607 PMID:23185045 NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430 		JBrowse link
G Mir145 microRNA 145 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Mir150 microRNA 150 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108 		JBrowse link
G Mir15b microRNA 15b part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir16 microRNA 16 part_of ISO (PMID:22503104), (PMID:24205035) RGD PMID:22503104 PMID:24205035 NCBI chr 2:153,245,349...153,245,443
Ensembl chr 2:153,245,349...153,245,443 		JBrowse link
G Mir17 microRNA 17 part_of ISO (PMID:23185045), (PMID:24205035) RGD PMID:23185045 PMID:24205035 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir181c microRNA 181c part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628 		JBrowse link
G Mir194-1 microRNA 194-1 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr13:96,851,166...96,851,248
Ensembl chr13:96,851,166...96,851,248 		JBrowse link
G Mir194-2 microRNA 194-2 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 1:203,564,761...203,564,845
Ensembl chr 1:203,564,761...203,564,845 		JBrowse link
G Mir195 microRNA 195 part_of ISO (PMID:24205035) RGD PMID:24205035 NCBI chr10:54,951,838...54,951,924
Ensembl chr10:54,951,838...54,951,924 		JBrowse link
G Mir19b1 microRNA 19b-1 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr15:92,181,214...92,181,300
Ensembl chr15:92,181,214...92,181,300 		JBrowse link
G Mir19b2 microRNA 19b-2 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr  X:132,422,072...132,422,167
Ensembl chr  X:132,422,072...132,422,167 		JBrowse link
G Mir1b microRNA 1b part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 3:167,487,117...167,487,201
Ensembl chr 3:167,487,117...167,487,201 		JBrowse link
G Mir206 microRNA 206 part_of ISO UniProtKB:Q9UKV8 (PMID:31507089) RGD PMID:31507089 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332 		JBrowse link
G Mir20a microRNA 20a part_of ISO (PMID:23185045), (PMID:24205035) RGD PMID:23185045 PMID:24205035 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir20b microRNA 20b part_of ISO (PMID:24205035) RGD PMID:24205035 NCBI chr  X:132,422,211...132,422,282
Ensembl chr  X:132,422,211...132,422,282 		JBrowse link
G Mir21 microRNA 21 part_of ISO (PMID:22503104), (PMID:23185045) RGD PMID:22503104 PMID:23185045 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir219a1 microRNA 219a-1 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr20:4,829,687...4,829,796
Ensembl chr20:4,829,687...4,829,796 		JBrowse link
G Mir221 microRNA 221 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Mir222 microRNA 222 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006 		JBrowse link
G Mir23a microRNA 23a part_of ISO (PMID:24101522) RGD PMID:24101522 NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071 		JBrowse link
G Mir26a microRNA 26a part_of ISO (PMID:24205035) RGD PMID:24205035 NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378 		JBrowse link
G Mir26b microRNA 26b part_of ISO (PMID:24205035) RGD PMID:24205035 NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680 		JBrowse link
G Mir27a microRNA 27a part_of ISO (PMID:22503104) RGD PMID:22503104 NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917 		JBrowse link
G Mir28 microRNA 28 part_of ISO (PMID:22503104) RGD PMID:22503104 NCBI chr11:75,975,523...75,975,608
Ensembl chr11:75,975,523...75,975,608 		JBrowse link
G Mir298 microRNA 298 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 3:163,052,291...163,052,372
Ensembl chr 3:163,052,291...163,052,372 		JBrowse link
G Mir29a microRNA 29a part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 4:59,650,608...59,650,695 JBrowse link
G Mir30a microRNA 30a part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670 		JBrowse link
G Mir30c1 microRNA 30c-1 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 5:134,349,237...134,349,325
Ensembl chr 5:134,349,237...134,349,325 		JBrowse link
G Mir30c2 microRNA 30c-2 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 9:25,757,342...25,757,425
Ensembl chr 9:25,757,342...25,757,425 		JBrowse link
G Mir31 microRNA 31 part_of ISO UniProtKB:Q9UKV8 (PMID:31012336) RGD PMID:31012336 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Mir320a microRNA 320a part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473 		JBrowse link
G Mir322 microRNA 322 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr  X:132,806,594...132,806,688
Ensembl chr  X:132,806,594...132,806,688 		JBrowse link
G Mir324 microRNA 324 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr10:54,734,680...54,734,762
Ensembl chr10:54,734,678...54,734,766 		JBrowse link
G Mir326 microRNA 326 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 1:153,854,029...153,854,123
Ensembl chr 1:153,854,029...153,854,123 		JBrowse link
G Mir328 microRNA 328 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr19:33,184,766...33,184,849
Ensembl chr19:33,184,766...33,184,849 		JBrowse link
G Mir331 microRNA 331 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 7:28,527,390...28,527,485
Ensembl chr 7:28,527,390...28,527,485 		JBrowse link
G Mir342 microRNA 342 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 6:127,565,269...127,565,367
Ensembl chr 6:127,565,269...127,565,367 		JBrowse link
G Mir345 microRNA 345 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 6:127,754,027...127,754,122
Ensembl chr 6:127,754,027...127,754,122 		JBrowse link
G Mir34c microRNA 34c part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 8:51,409,726...51,409,802
Ensembl chr 8:51,409,726...51,409,802 		JBrowse link
G Mir361 microRNA 361 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr  X:78,246,206...78,246,275
Ensembl chr  X:78,246,206...78,246,275 		JBrowse link
G Mir451a microRNA 451a part_of ISO (PMID:20424607), (PMID:22503104), (PMID:24205035), (PMID:7949730) RGD PMID:7949730 PMID:20424607 PMID:22503104 PMID:24205035 NCBI chr10:62,961,520...62,961,591
Ensembl chr10:62,961,520...62,961,591 		JBrowse link
G Mir455 microRNA 455 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 5:76,689,313...76,689,390
Ensembl chr 5:76,689,313...76,689,390 		JBrowse link
G Mir486 microRNA 486 part_of ISO (PMID:23185045) RGD PMID:23185045
G Mir500 microRNA 500 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr  X:15,258,778...15,258,857
Ensembl chr  X:15,258,768...15,258,859 		JBrowse link
G Mir532 microRNA 532 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr  X:15,247,315...15,247,393
Ensembl chr  X:15,247,315...15,247,393 		JBrowse link
G Mir652 microRNA 652 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr  X:106,343,293...106,343,373
Ensembl chr  X:106,343,293...106,343,373 		JBrowse link
G Mir7-1 microRNA 7-1 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr17:6,273,264...6,273,360
Ensembl chr17:6,273,264...6,273,360 		JBrowse link
G Mir708 microRNA 708 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 1:150,599,876...150,599,963
Ensembl chr 1:150,599,876...150,599,963 		JBrowse link
G Mirlet7a1 microRNA let-7a-1 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr17:16,113,766...16,113,859
Ensembl chr17:16,113,768...16,113,867 		JBrowse link
G Mirlet7b microRNA let-7b part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270 		JBrowse link
G Mirlet7c1 microRNA let-7c-1 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265 		JBrowse link
G Mirlet7c2 microRNA let7c-2 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 7:116,803,771...116,803,865
Ensembl chr 7:116,803,771...116,803,865 		JBrowse link
G Mirlet7d microRNA let-7d part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990 		JBrowse link
G Mirlet7f-1 microRNA let7f-1 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr17:16,114,130...16,114,226
Ensembl chr17:16,114,130...16,114,226 		JBrowse link
G Mirlet7f2 microRNA let-7f-2 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr  X:20,980,632...20,980,714
Ensembl chr  X:20,980,632...20,980,714 		JBrowse link
G Mirlet7g microRNA let-7g part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 8:106,822,293...106,822,380
Ensembl chr 8:106,822,280...106,822,388 		JBrowse link
G Mirlet7i microRNA let-7i part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571 		JBrowse link
G Prkra protein activator of interferon induced protein kinase EIF2AK2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:61,575,447...61,594,393
Ensembl chr 3:61,575,447...61,594,347 		JBrowse link
G Ran RAN, member RAS oncogene family part_of ISO (PMID:19965479) RGD PMID:19965479 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276 		JBrowse link
G Scarna15 small Cajal body-specific RNA 15 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 1:135,484,620...135,484,683
Ensembl chr 1:135,484,559...135,484,685
Ensembl chr 1:135,484,559...135,484,685 		JBrowse link
G Snora58 small nucleolar RNA, H/ACA box 58 part_of ISO (PMID:23185045) RGD PMID:23185045 NCBI chr 6:107,080,945...107,081,020
Ensembl chr 6:107,080,945...107,081,020 		JBrowse link
G Tarbp2 Tarbp2 subunit of RISC loading complex part_of ISO
ISS
IEA
IBA		 (PMID:17531811)
GO_REF:0000024
GO_REF:0000104
GO_REF:0000033
(PMID:22503104)		 RGD
UniProt
GO_Central		 PMID:17531811 PMID:22503104 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr 7:133,649,118...133,654,306
Ensembl chr 7:133,649,090...133,654,314 		JBrowse link
G Tnrc6a trinucleotide repeat containing adaptor 6A part_of ISO (PMID:17671087) RGD PMID:17671087 NCBI chr 1:177,561,898...177,715,669
Ensembl chr 1:177,646,030...177,715,660 		JBrowse link
G Xpo5 exportin 5 part_of ISO (PMID:19965479) RGD PMID:19965479 NCBI chr 9:14,740,182...14,778,171
Ensembl chr 9:14,740,182...14,778,171 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20829
    protein-containing complex 6557
      ribonucleoprotein complex 1235
        RNAi effector complex 87
          RISC complex 86
paths to the root