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ONTOLOGY REPORT - ANNOTATIONS


Term:protein-containing complex
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Accession:GO:0032991 term browser browse the term
Definition:A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
Comment:A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.
Synonyms:exact_synonym: macromolecular complex;   macromolecule complex
 narrow_synonym: protein complex;   protein-protein complex
 alt_id: GO:0043234



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      cellular_component 19969
        protein-containing complex 6165
          3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex 0
          3M complex 6
          ADPG pyrophosphorylase complex + 0
          AIP1-IRE1 complex 2
          APC-IQGAP complex 0
          APC-IQGAP1-CLIP-170 complex 0
          APC-IQGAP1-Cdc42 complex 0
          APC-IQGAP1-Rac1 complex 0
          APC-tubulin-IQGAP1 complex 0
          ASAP complex 5
          ATPase inhibitor complex + 3
          Aim21-Tda2 complex 0
          AnxA2-p11 complex 2
          Arp2/3 protein complex 10
          B800-820 antenna complex 0
          B800-850 antenna complex 0
          B875 antenna complex 0
          BBSome 8
          BID-BCL-xl complex 0
          BLOC complex + 20
          BORC complex 8
          Bcl-2 family protein complex + 9
          CAF-1 complex 3
          CBF3 complex 0
          CBM complex 4
          CCR4-NOT core complex 6
          CD20-Lck-Fyn complex 0
          CD20-Lck-Lyn-Fyn complex 0
          CENP-A recruiting complex 0
          CENP-T-W-S-X complex 0
          CHOP-ATF3 complex 2
          CIA complex 5
          CNTFR-CLCF1 complex 2
          CRD-mediated mRNA stability complex 6
          CRLF-CLCF1 complex 2
          CSF1-CSF1R complex 2
          CSK-GAP-A.p62 complex 0
          CUGBP1-eIF2 complex 0
          Cbf1-Met4-Met28 complex 0
          Cdc24p-Far1p-Gbetagamma complex 0
          Cdc42 GTPase complex 0
          CoA-synthesizing protein complex 0
          Ctf18 RFC-like complex 8
          Cvt complex 0
          DNA bending complex + 0
          DNA packaging complex + 133
          DNA recombinase mediator complex + 10
          DNA repair complex + 42
          DNA replication factor C complex + 5
          DNA topoisomerase III-beta-TDRD3 complex 2
          DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex + 1
          DiaA complex 0
          DnaB-DnaC complex 0
          Dom34-Hbs1 complex 0
          Dxr protein complex 0
          EARP complex 5
          EDS1 disease-resistance complex 0
          EKC/KEOPS complex 9
          ER membrane insertion complex + 5
          ESCRT complex + 26
          F-actin capping protein complex + 9
          FAL1-SGD1 complex 0
          FAR/SIN/STRIPAK complex 4
          FHF complex 6
          G-protein beta/gamma-Btk complex 0
          G-protein beta/gamma-Raf-1 complex 0
          G-protein beta/gamma-subunit complex 3
          GAIT complex 4
          GATOR1 complex 6
          GATOR2 complex 10
          GLI-SUFU complex 3
          Gtr1-Gtr2 GTPase complex 4
          H-NS-Hha complex 0
          HICS complex 0
          HIR complex 1
          IKKalpha-IKKalpha complex 0
          IRE1-RACK1-PP2A complex 2
          KICSTOR complex 5
          Kelch-containing formin regulatory complex 0
          Kibra-Ex-Mer complex 0
          L-cysteine desulfurase complex + 2
          Lsd1/2 complex 0
          MAD1 complex 1
          MAML1-RBP-Jkappa- ICN1 complex 4
          MCM complex + 12
          MCM core complex 0
          MECO complex 0
          MIH complex 0
          MIS12/MIND type complex + 4
          MKS complex 14
          MMXD complex 5
          MWP complex 1
          Mcs4 RR-MAPKKK complex 0
          Mis6-Sim4 complex 3
          Mon1-Ccz1 complex 4
          Myo2p-Vac17p-Vac8p transport complex 0
          NAD(P)H dehydrogenase complex (plastoquinone) + 0
          NHE3/E3KARP/ACTN4 complex 0
          NMS complex + 4
          NOS2-CD74 complex 1
          NPHP complex 0
          NVT complex 0
          Ndc80 complex 4
          Nicalin-NOMO complex 0
          Nrd1 complex 0
          Nsk1-Dlc1 complex 0
          PAN complex 2
          PCSK9-AnxA2 complex 2
          PCSK9-LDLR complex 2
          PET complex 3
          PTEX complex 0
          PYM-mago-Y14 complex 0
          Par3-APC-KIF3A complex 0
          Prp19 complex 15
          R2TP complex 6
          RAVE complex 3
          RNA cap binding complex + 11
          RPAP3/R2TP/prefoldin-like complex 12
          RQC complex 4
          RZZ complex 3
          Rad17 RFC-like complex 1
          Ras guanyl-nucleotide exchange factor complex 0
          RasGAP-Fyn-Lyn-Yes complex 0
          RecFOR complex 0
          RecQ family helicase-topoisomerase III complex 4
          Rix1 complex 1
          Rvs161p-Rvs167p complex 0
          S100A8 complex 0
          SCAR complex 13
          SLAC complex 0
          SMAD protein complex + 10
          Scrib-APC complex 0
          Scrib-APC-beta-catenin complex 3
          Seh1-associated complex + 15
          Sid2-Mob1 complex 0
          Ski complex 3
          Sm-like protein family complex + 88
          SsuD-SsuE complex 0
          Ste12p-Dig1p-Dig2p complex 0
          Syp1 complex 0
          TAM protein secretion complex 0
          TBK1-IKKE-DDX3 complex 0
          TCR signalosome 2
          TOC-TIC supercomplex I 0
          TRAF2-GSTP1 complex 2
          TSC1-TSC2 complex 5
          TTT complex 3
          Tec1p-Ste12p-Dig1p complex 0
          UFD1-NPL4 complex 2
          USH2 complex 4
          Ubp3-Bre5 deubiquitination complex 0
          VCP-NSFL1C complex 2
          VRK3/VHR/ERK complex 0
          Vma12-Vma22 assembly complex 0
          WASH complex 10
          Wnt signalosome 9
          Y-shaped link 0
          Yae1-Lto1 complex 0
          acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex 0
          actin cytoskeleton-regulatory complex 0
          activin complex + 1
          acyl-CoA ceramide synthase complex 0
          aminoacyl-tRNA synthetase multienzyme complex 13
          amyloid-beta complex 2
          anaerobic ribonucleoside-triphosphate reductase complex 0
          angiogenin-PRI complex 2
          apoptosome 4
          axonemal heterotrimeric kinesin-II complex 0
          axonemal nexin link 0
          beta-catenin destruction complex 10
          bub1-bub3 complex 1
          bursicon neuropeptide hormone complex 0
          calprotectin complex 0
          catalytic complex + 1549
          cell envelope Sec protein transport complex 0
          centralspindlin complex 3
          centriolar subdistal appendage 10
          chaperone complex + 34
          ciliary centrin arm 0
          ciliary transition fiber 10
          classical-complement-pathway C3/C5 convertase complex 3
          cohesin complex + 11
          collagen trimer + 61
          complement component C1 complex 1
          complement component C1q complex 3
          counting factor complex 0
          cytochrome complex + 45
          cytosolic tRNA wobble base thiouridylase complex 1
          divisome complex + 0
          eisosome filament 0
          endopeptidase Clp complex + 2
          endoplasmic reticulum protein-containing complex + 139
          enzyme activator complex + 4
          eukaryotic translation elongation factor 1 complex 4
          eukaryotic translation initiation factor 2 complex 6
          eukaryotic translation initiation factor 2B complex 6
          eukaryotic translation initiation factor 3 complex + 16
          eukaryotic translation initiation factor 4F complex 7
          exomer complex 0
          extracellular exosome complex + 0
          fatty acid beta-oxidation multienzyme complex + 2
          fatty acid synthase complex 0
          ferritin complex + 2
          fibrinogen complex 6
          filamentous actin 38
          formyl-methanofuran dehydrogenase (molybdenum enzyme) complex 0
          formyl-methanofuran dehydrogenase (tungsten enzyme) complex 0
          gamma-tubulin complex + 14
          glycoprotein complex + 25
          growth factor complex + 7
          guanylate cyclase complex, soluble 2
          haptoglobin-hemoglobin complex 12
          hemidesmosome associated protein complex + 0
          hemoglobin complex 12
          histone mRNA stem-loop binding complex 2
          immunoglobulin complex + 113
          inflammasome complex + 24
          inhibin complex + 3
          inner kinetochore + 5
          interferon regulatory factor complex + 0
          interleukin-12 complex 2
          interleukin-23 complex 2
          interleukin-27 complex 0
          interleukin-35 complex 0
          intracellular protein-containing complex + 776
          intraciliary transport particle + 29
          intraciliary transport particle A 8
          intraciliary transport particle B 22
          iron-sulfur cluster assembly complex + 6
          junctional membrane complex 8
          laminin complex + 12
          large latent transforming growth factor-beta complex 1
          larval serum protein complex 0
          lateral cortical node 0
          light-harvesting complex + 0
          lymphotoxin complex 0
          lysosomal multienzyme complex 0
          mCRD-mediated mRNA stability complex 6
          mRNA editing complex + 9
          matrilin complex 3
          membrane fusion priming complex 0
          membrane protein complex + 1262
          metallochaperone complex + 0
          methionyl glutamyl tRNA synthetase complex 0
          methyl accepting chemotaxis protein complex 0
          methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex 0
          microtubule associated complex + 150
          mitochondrial protein-containing complex + 314
          mitotic spindle assembly checkpoint MAD1-MAD2 complex 2
          molybdopterin synthase complex 2
          monopolin complex 0
          muscle thin filament tropomyosin 0
          myosin complex + 56
          nascent polypeptide-associated complex 9
          nitrite reductase complex [NAD(P)H] 0
          nuclear protein-containing complex + 1289
          nucleocytoplasmic transport complex + 12
          nucleotide-excision repair, DNA damage recognition complex + 0
          origin recognition complex + 8
          ornithine carbamoyltransferase inhibitor complex 0
          outer dynein arm docking complex 1
          outer kinetochore + 14
          paraferritin complex 1
          peptidase inhibitor complex + 10
          phosphoenolpyruvate-dependent sugar phosphotransferase complex 0
          pituitary gonadotropin complex + 2
          polarisome + 0
          polkadots 2
          polycystin complex 2
          polyketide synthase complex + 0
          prefoldin complex 6
          procentriole replication complex 6
          proteasome accessory complex + 27
          proteasome activator complex 5
          proteasome core complex + 24
          proteasome core complex, alpha-subunit complex + 9
          proteasome core complex, beta-subunit complex + 14
          proteasome regulatory particle + 22
          proteasome regulatory particle, base subcomplex + 12
          proteasome regulatory particle, lid subcomplex + 8
          proteasome-activating nucleotidase complex 0
          protein complex involved in cell adhesion + 47
          protein phosphatase inhibitor complex 0
          protein-DNA complex + 234
          protein-DNA-RNA complex + 0
          protein-carbohydrate complex + 0
          protein-lipid complex + 36
          protein-lipid-RNA complex + 0
          pyrophosphate-dependent phosphofructokinase complex + 0
          pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex 0
          pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex 0
          pyroptosome complex 0
          radial spoke + 4
          radial spoke head 1
          radial spoke stalk 0
          raps-insc complex 0
          receptor complex + 419
          reelin complex 1
          replication inhibiting complex + 0
          ribonucleoprotein complex + 1230
          septin complex + 21
          single-stranded DNA-binding protein complex 0
          spectrin 7
          sperm individualization complex + 0
          spitzenkorper 0
          stereocilia ankle link complex 6
          steroid hormone aporeceptor complex 0
          subcortical maternal complex 4
          sumoylated E2 ligase complex 1
          thrombospondin complex 0
          titin-telethonin complex 2
          trans-synaptic protein complex 0
          transcription regulator complex + 503
          transforming growth factor beta activated kinase 1 complex 0
          transforming growth factor beta complex 3
          translation release factor complex 3
          translation repressor complex + 0
          transporter complex + 427
          tricarboxylic acid cycle enzyme complex + 17
          troponin complex + 9
          tubulin complex 1
          tubulin folding cofactor complex 0
          tubulobulbar complex + 3
          type I protein secretion system complex 0
          type II protein secretion system complex 0
          type III protein secretion system complex 0
          type IV secretion system complex 0
          type V protein secretion system complex 0
          type VI protein secretion system complex 0
          ubiquinone biosynthesis complex 6
          vesicle tethering complex + 74
          viral integration complex 0
          viral portal complex 0
          viral scaffold 0
          viral terminase complex + 0
          viral terminase, small subunit 0
          viral transcriptional complex 0
          zona pellucida receptor complex 13
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