Mir106a (microRNA 106a) - Rat Genome Database

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Gene: Mir106a (microRNA 106a) Rattus norvegicus
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Symbol: Mir106a
Name: microRNA 106a
RGD ID: 2325506
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in negative regulation of macromolecule biosynthetic process and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within several processes, including cellular response to forskolin; cellular response to leukemia inhibitory factor; and long-term synaptic potentiation. Predicted to be located in extracellular exosome. Predicted to be part of RISC complex. Orthologous to human MIR106A (microRNA 106a); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH tamoxifen; all-trans-retinoic acid (ortholog); arsane (ortholog).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA 17-2; microRNA mir-17-2; Mir17-2; rno-mir-17-2
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X137,343,570 - 137,343,647 (-)NCBIGRCr8
mRatBN7.2X132,422,584 - 132,422,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX132,422,584 - 132,422,661 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX134,584,992 - 134,585,069 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X138,166,933 - 138,167,010 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X135,732,637 - 135,732,714 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X140,117,891 - 140,117,968 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX140,117,891 - 140,117,968 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X140,167,738 - 140,167,815 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX131,322,799 - 131,322,876 (-)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Epigenetic mechanisms in Parkinson's disease. Feng Y, etal., J Neurol Sci. 2015 Feb 15;349(1-2):3-9. doi: 10.1016/j.jns.2014.12.017. Epub 2014 Dec 18.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15345052   PMID:16381832   PMID:17604727   PMID:18320040   PMID:18329372   PMID:19147652   PMID:20403161   PMID:20439489   PMID:21993888   PMID:24205035   PMID:25858512   PMID:30468455  
PMID:35730503  


Genomics

Comparative Map Data
Mir106a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X137,343,570 - 137,343,647 (-)NCBIGRCr8
mRatBN7.2X132,422,584 - 132,422,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX132,422,584 - 132,422,661 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX134,584,992 - 134,585,069 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X138,166,933 - 138,167,010 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X135,732,637 - 135,732,714 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X140,117,891 - 140,117,968 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX140,117,891 - 140,117,968 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X140,167,738 - 140,167,815 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX131,322,799 - 131,322,876 (-)NCBICelera
Cytogenetic MapXq36NCBI
MIR106A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X134,170,198 - 134,170,278 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX134,170,198 - 134,170,278 (-)EnsemblGRCh38hg38GRCh38
GRCh37X133,304,228 - 133,304,308 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X133,131,893 - 133,131,973 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX133,691,061 - 133,691,141 (-)NCBICelera
Cytogenetic MapXq26.2NCBI
HuRefX122,702,267 - 122,702,347 (-)NCBIHuRef
CHM1_1X133,215,924 - 133,216,004 (-)NCBICHM1_1
T2T-CHM13v2.0X132,495,345 - 132,495,425 (-)NCBIT2T-CHM13v2.0
Mir106a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X51,831,380 - 51,831,444 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX51,831,380 - 51,831,444 (-)EnsemblGRCm39 Ensembl
GRCm38X52,742,503 - 52,742,567 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX52,742,503 - 52,742,567 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X50,095,680 - 50,095,744 (-)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX40,158,723 - 40,158,787 (-)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX29.15NCBI

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:9683
Count of gene targets:5678
Count of transcripts:6125
Interacting mature miRNAs:rno-miR-17-2-3p, rno-miR-17-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat


Expression

RNA-SEQ Expression

endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
renal system
reproductive system
respiratory system
1 1 2 5 2 3 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_032265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX132,422,584 - 132,422,661 (-)Ensembl
Rnor_6.0 EnsemblX140,117,891 - 140,117,968 (-)Ensembl
RefSeq Acc Id: NR_032265
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,343,570 - 137,343,647 (-)NCBI
mRatBN7.2X132,422,584 - 132,422,661 (-)NCBI
Rnor_6.0X140,117,891 - 140,117,968 (-)NCBI
Rnor_5.0X140,167,738 - 140,167,815 (-)NCBI
CeleraX131,322,799 - 131,322,876 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325506 AgrOrtholog
BioCyc Gene G2FUF-1013 BioCyc
Ensembl Genes ENSRNOG00000035592 Ensembl
miRBase MI0006131 ENTREZGENE
NCBI Gene 100314101 ENTREZGENE
PhenoGen Mir106a PhenoGen
RatGTEx ENSRNOG00000035592 RatGTEx
RNAcentral URS00002075FA RNACentral
  URS000075B27B RNACentral
  URS000075ECEC RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-27 Mir106a  microRNA 106a  Mir17-2  microRNA 17-2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-15 Mir17-2  microRNA 17-2  Mir17-2  microRNA mir-17-2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir17-2  microRNA mir-17-2      Symbol and Name status set to provisional 70820 PROVISIONAL