Mir19b2 (microRNA 19b-2) - Rat Genome Database

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Gene: Mir19b2 (microRNA 19b-2) Rattus norvegicus
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Symbol: Mir19b2
Name: microRNA 19b-2
RGD ID: 2325599
Description: Predicted to enable mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including cholesterol homeostasis; miRNA-mediated post-transcriptional gene silencing; and regulation of cellular response to transforming growth factor beta stimulus. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; long-term synaptic potentiation; and negative regulation of B cell apoptotic process. Predicted to be located in blood microparticle. Predicted to be part of RISC complex. Orthologous to human MIR19B2 (microRNA 19b-2); INTERACTS WITH cadmium atom; cadmium dichloride; rotenone.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-19b-2; Mir19b-2; rno-mir-19b-2
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X137,343,058 - 137,343,153 (-)NCBIGRCr8
mRatBN7.2X132,422,072 - 132,422,167 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX132,422,072 - 132,422,167 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX134,584,480 - 134,584,575 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X138,166,421 - 138,166,516 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X135,732,125 - 135,732,220 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X140,117,379 - 140,117,474 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX140,117,379 - 140,117,474 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X140,167,226 - 140,167,321 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX131,322,287 - 131,322,382 (-)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell apoptotic process  (ISO)
cellular response to bacterial lipopeptide  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cholesterol homeostasis  (ISO)
long-term synaptic potentiation  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of apolipoprotein A-I-mediated signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of B cell apoptotic process  (ISO)
negative regulation of cardiac epithelial to mesenchymal transition  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of coagulation  (ISO)
negative regulation of extracellular matrix assembly  (ISO)
negative regulation of fibroblast migration  (ISO)
negative regulation of G2/M transition of mitotic cell cycle  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response to antigenic stimulus  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of matrix metallopeptidase secretion  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
ossification  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
response to bacterium  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:16381832   PMID:16766679   PMID:17604727   PMID:18329372   PMID:20403161   PMID:20439489   PMID:23185045   PMID:24205035   PMID:25650006   PMID:25751060   PMID:25858512  
PMID:33332749   PMID:36539014  


Genomics

Comparative Map Data
Mir19b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X137,343,058 - 137,343,153 (-)NCBIGRCr8
mRatBN7.2X132,422,072 - 132,422,167 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX132,422,072 - 132,422,167 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX134,584,480 - 134,584,575 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X138,166,421 - 138,166,516 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X135,732,125 - 135,732,220 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X140,117,379 - 140,117,474 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX140,117,379 - 140,117,474 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X140,167,226 - 140,167,321 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX131,322,287 - 131,322,382 (-)NCBICelera
Cytogenetic MapXq36NCBI
MIR19B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X134,169,671 - 134,169,766 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX134,169,671 - 134,169,766 (-)EnsemblGRCh38hg38GRCh38
GRCh37X133,303,701 - 133,303,796 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X133,131,366 - 133,131,461 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX133,690,534 - 133,690,629 (-)NCBICelera
Cytogenetic MapXq26.2NCBI
HuRefX122,701,740 - 122,701,835 (-)NCBIHuRef
CHM1_1X133,215,397 - 133,215,492 (-)NCBICHM1_1
T2T-CHM13v2.0X132,494,818 - 132,494,913 (-)NCBIT2T-CHM13v2.0
Mir19b-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X51,830,860 - 51,830,943 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX51,830,860 - 51,830,943 (-)EnsemblGRCm39 Ensembl
GRCm38X52,741,983 - 52,742,066 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX52,741,983 - 52,742,066 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X50,095,160 - 50,095,243 (-)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX40,158,203 - 40,158,286 (-)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX29.15NCBI
MIR19B-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X104,895,962 - 104,896,025 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX104,895,962 - 104,896,025 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX91,006,321 - 91,006,384 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X106,755,718 - 106,755,781 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX106,755,718 - 106,755,781 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X104,168,894 - 104,168,957 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X106,034,839 - 106,034,902 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X105,820,105 - 105,820,168 (-)NCBIUU_Cfam_GSD_1.0
MIR19B-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX110,113,855 - 110,113,934 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X110,113,855 - 110,113,934 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X126,199,650 - 126,199,729 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:10994
Count of gene targets:6582
Count of transcripts:7067
Interacting mature miRNAs:rno-miR-19b-2-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system renal system reproductive system
High
Medium
Low 6 9 2 4
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000053702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX132,422,072 - 132,422,167 (-)Ensembl
Rnor_6.0 EnsemblX140,117,379 - 140,117,474 (-)Ensembl
RefSeq Acc Id: NR_031821
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,343,058 - 137,343,153 (-)NCBI
mRatBN7.2X132,422,072 - 132,422,167 (-)NCBI
Rnor_6.0X140,117,379 - 140,117,474 (-)NCBI
Rnor_5.0X140,167,226 - 140,167,321 (-)NCBI
CeleraX131,322,287 - 131,322,382 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325599 AgrOrtholog
BioCyc Gene G2FUF-1019 BioCyc
Ensembl Genes ENSRNOG00000035579 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053702 ENTREZGENE
miRBase MI0000848 ENTREZGENE
NCBI Gene 100313999 ENTREZGENE
PhenoGen Mir19b2 PhenoGen
RatGTEx ENSRNOG00000035579 RatGTEx
RNAcentral URS000013D17D RNACentral
  URS000075C3EC RNACentral
  URS000075F060 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir19b2  microRNA 19b-2  Mir19b-2  microRNA mir-19b-2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir19b-2  microRNA mir-19b-2      Symbol and Name status set to provisional 70820 PROVISIONAL