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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of muscle hypertrophy
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Accession:GO:0014741 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy.


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negative regulation of muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mstn myostatin IMP RGD PMID:16810717 RGD:2303557 NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933 		JBrowse link
negative regulation of cardiac muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp10 bone morphogenetic protein 10 involved_in IEA
ISO		 GO_REF:0000107
(MGI:3695247|PMID:16798733)		 Ensembl
RGD		 PMID:16798733 GO_REF:0000107 MGI:3695247 NCBI chr 4:119,872,066...119,877,694
Ensembl chr 4:119,872,045...119,878,627 		JBrowse link
G Cav3 caveolin 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:12847114)
MGI:2180558 (PMID:18552160)		 RGD PMID:12847114 PMID:18552160 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137 		JBrowse link
G Fbxo32 F-box protein 32 involved_in IMP PMID:24117217 BHF-UCL PMID:24117217 RGD:11079185 NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436 		JBrowse link
G Gata5 GATA binding protein 5 involved_in ISO (MGI:5286818|PMID:21633169) RGD PMID:21633169 MGI:5286818 NCBI chr 3:167,418,563...167,426,751
Ensembl chr 3:167,418,565...167,426,751 		JBrowse link
G Gdf1 growth differentiation factor 1 IMP RGD PMID:24275554 RGD:11252017 NCBI chr16:19,097,309...19,112,519
Ensembl chr16:19,097,314...19,112,519 		JBrowse link
G Glrx3 glutaredoxin 3 involved_in ISO (MGI:4461873|PMID:18258855) RGD PMID:18258855 MGI:4461873 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta acts_upstream_of_or_within ISO (PMID:11782539) RGD PMID:11782539 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 involved_in IGI
IMP		 PMID:24657879 BHF-UCL PMID:24657879 PMID:24657879 RGD:11344938, RGD:11344938 NCBI chr17:19,777,487...19,957,696
Ensembl chr17:19,777,266...19,955,690 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 IMP RGD PMID:28679649 RGD:329955564 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Mir1 microRNA 1 involved_in ISO (PMID:19933931) RGD PMID:19933931 NCBI chr18:1,887,537...1,887,623 JBrowse link
G Mir1b microRNA 1b involved_in ISO (PMID:19933931) RGD PMID:19933931 NCBI chr 3:167,487,117...167,487,201
Ensembl chr 3:167,487,117...167,487,201 		JBrowse link
G Mlip muscular LMNA-interacting protein involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
(PMID:22343712)		 UniProt
RGD		 PMID:22343712 GO_REF:0000024 NCBI chr 8:77,935,087...78,204,725
Ensembl chr 8:77,935,079...78,204,254 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:6158728|PMID:26491108) RGD PMID:26491108 MGI:6158728 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G P2rx4 purinergic receptor P2X 4 involved_in ISO (PMID:15130891) RGD PMID:15130891 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 involved_in ISO (MGI:3836877|PMID:19127022) RGD PMID:19127022 MGI:3836877 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO		 GO_REF:0000107
(MGI:3689643|PMID:16151019)		 Ensembl
RGD		 PMID:16151019 GO_REF:0000107 MGI:3689643 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in IMP PMID:30980393 UniProt PMID:30980393 RGD:401901224 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A involved_in ISO UniProtKB:P25119 (MGI:6158728|PMID:26491108) RGD PMID:26491108 MGI:6158728 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B involved_in ISO UniProtKB:P25118 (MGI:6158728|PMID:26491108) RGD PMID:26491108 MGI:6158728 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Trim63 tripartite motif containing 63 involved_in IMP PMID:24117217 BHF-UCL PMID:24117217 RGD:11079185 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322 		JBrowse link
negative regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in ISO (PMID:19287093)
(MGI:3848765|PMID:19287093)		 RGD PMID:19287093 MGI:3848765 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 IDA RGD PMID:19204184 RGD:9685562 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Foxo1 forkhead box O1 involved_in IMP PMID:26436652 UniProt PMID:26436652 RGD:13210548 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Lmna lamin A/C involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:5700584|PMID:26436652)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:26436652 GO_REF:0000024 GO_REF:0000107 MGI:5700584 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Mlip muscular LMNA-interacting protein involved_in ISO (MGI:5700584|PMID:26436652), (MGI:5908525|PMID:26359501) RGD PMID:26359501 PMID:26436652 MGI:5700584 MGI:5908525 NCBI chr 8:77,935,087...78,204,725
Ensembl chr 8:77,935,079...78,204,254 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma acts_upstream_of_or_within IDA PMID:29695452 BHF-UCL PMID:29695452 RGD:150521636 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Smad3 SMAD family member 3 involved_in IGI PMID:27038547 BHF-UCL PMID:27038547 RGD:11535100 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
negative regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap1 A-kinase anchoring protein 1 IMP RGD PMID:19358331 RGD:2312604 NCBI chr10:73,621,021...73,654,123
Ensembl chr10:73,621,883...73,653,896 		JBrowse link
G Cav3 caveolin 3 IMP RGD PMID:21170593 RGD:6784534 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137 		JBrowse link
G Ctdp1 CTD phosphatase subunit 1 IMP RGD PMID:22569295 RGD:9686371 NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457 		JBrowse link
G Foxp1 forkhead box P1 IMP RGD PMID:26333362 RGD:11561912 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase IMP RGD PMID:24190878 RGD:10449133 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO
IEA		 (MGI:4829580|PMID:20516643)
GO_REF:0000107		 RGD
Ensembl		 PMID:20516643 GO_REF:0000107 MGI:4829580 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Mir451a microRNA 451a IMP RGD PMID:25209900 RGD:11558015 NCBI chr10:62,961,520...62,961,591
Ensembl chr10:62,961,520...62,961,591 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 IMP RGD PMID:22082674 RGD:11533929 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Pi16 peptidase inhibitor 16 acts_upstream_of_or_within ISO (PMID:17909105) RGD PMID:17909105 NCBI chr20:7,376,073...7,385,386
Ensembl chr20:7,376,126...7,385,383 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha IMP RGD PMID:22198280 RGD:5687133 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Rbm10 RNA binding motif protein 10 IMP RGD PMID:30257214 RGD:151667449 NCBI chr  X:1,540,399...1,572,571
Ensembl chr  X:1,540,398...1,572,575 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 IMP RGD PMID:16380388 RGD:13524577 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 IDA RGD PMID:9918533 RGD:7207376 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 IMP RGD PMID:25022898 RGD:13464131 NCBI chr11:43,378,719...43,417,166
Ensembl chr11:43,377,216...43,417,202 		JBrowse link
G Yy1 YY1 transcription factor IMP RGD PMID:18632988 RGD:9588273 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
G Zfp418 zinc finger protein 418 acts_upstream_of_or_within ISO (PMID:29065170) RGD PMID:29065170 NCBI chr 1:66,581,406...66,594,247
Ensembl chr 1:66,581,287...66,594,242 		JBrowse link
negative regulation of skeletal muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igfbp5 insulin-like growth factor binding protein 5 involved_in ISO (MGI:3039207|PMID:15010534) RGD PMID:15010534 MGI:3039207 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    negative regulation of biological process 5811
      negative regulation of multicellular organismal process 1334
        negative regulation of muscle hypertrophy 42
          negative regulation of cardiac muscle hypertrophy + 40
          negative regulation of skeletal muscle hypertrophy 1
          negative regulation of smooth muscle hypertrophy 0
Path 2
Term Annotations click to browse term
  biological_process 20115
    biological regulation 13552
      regulation of biological process 13126
        regulation of multicellular organismal process 3333
          regulation of system process 679
            regulation of muscle system process 283
              regulation of muscle hypertrophy 90
                negative regulation of muscle hypertrophy 42
                  negative regulation of cardiac muscle hypertrophy + 40
                  negative regulation of skeletal muscle hypertrophy 1
                  negative regulation of smooth muscle hypertrophy 0
paths to the root