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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:acute necrotizing pancreatitis
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Accession:DOID:0080998 term browser browse the term
Definition:An acute pancreatitis that is characterized by one or more areas of necrosis in the pancreas with varying degree of involvement of the surrounding tissues or organ systems. (DO)
Synonyms:exact_synonym: necrotizing pancreatitis
 primary_id: MESH:D019283
 alt_id: DOID:9006745


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acute necrotizing pancreatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 IDA RGD PMID:15702783 RGD:2325308 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Arg1 arginase 1 IDA RGD PMID:20697209 RGD:4142795 NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Becn1 beclin 1 IEP protein:increased expression:pancreas RGD PMID:21926933 RGD:6483068 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 IEP mRNA:increased expression:pancreas RGD PMID:12604914 RGD:2293139 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 IEP mRNA:increased expression:liver, kidney, pancreas RGD PMID:9712737 RGD:2289078 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G C5 complement C5 ISO RGD PMID:11292607 RGD:5130168 NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G C5ar1 complement C5a receptor 1 ISO RGD PMID:11292607 RGD:5130168 NCBI chr 1:86,077,309...86,088,001 JBrowse link
G Calca calcitonin-related polypeptide alpha resistance IDA RGD PMID:19684430 RGD:5684345 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Casp3 caspase 3 IEP RGD PMID:18288275 RGD:2293324 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 severity
treatment		 IEP
IDA		 mRNA:increased expression:pancreas RGD PMID:18642776 PMID:19050604 RGD:2307010, RGD:11062108 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd46 CD46 molecule severity IEP RGD PMID:16425382 RGD:1600479 NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cd59b CD59b molecule severity IEP protein:decreased expression:pancreas, acinar cell RGD PMID:16425382 RGD:1600479 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Ctsb cathepsin B IEP protein:increased activity:pancreas (rat) RGD PMID:17723883 RGD:2315517 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 IEP mRNA:increased expression:pancreatic acinar cell RGD PMID:19818401 RGD:5135004 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 severity IEP RGD PMID:18642776 RGD:2307010 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP protein:increased expression:pancreas, lung (rat) RGD PMID:20950211 RGD:4145335 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il17a interleukin 17A IEP protein:increased expression:pancreas, serum (rat) RGD PMID:22990529 RGD:9068935 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1b interleukin 1 beta IEP mRNA:increased expression:peritoneal macrophages (rat) RGD PMID:22964727 RGD:7204517 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO rat model treated with human protein RGD PMID:7736749 RGD:8551826 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il6 interleukin 6 treatment IDA
IEP		 protein:increased expression:plasma (rat) RGD PMID:11780340 PMID:19050604 RGD:11062058, RGD:11062108 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mif macrophage migration inhibitory factor IDA RGD PMID:12612911 RGD:727512 NCBI chr20:12,767,138...12,791,222
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504 		JBrowse link
G Mmp2 matrix metallopeptidase 2 IEP mRNA:increased expression:pancreas (rat) RGD PMID:11590325 RGD:7207204 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Nfkbia NFKB inhibitor alpha treatment IEP RGD PMID:19174608 RGD:10414072 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos1 nitric oxide synthase 1 treatment IDA RGD PMID:23300603 RGD:7257665 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 IEP protein:increased enzyme activity:pancreas RGD PMID:15257108 RGD:2325241 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 IEP protein:increased expression:epithelial cell of pancreas (rat) RGD PMID:12210084 RGD:2311232 NCBI chr12:12,793,957...12,799,156
Ensembl chr12:7,757,865...7,763,064 		JBrowse link
G Pthlh parathyroid hormone-like hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:25035110 NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEP protein:increased expression:pancreas RGD PMID:18241655 RGD:2298789 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Selp selectin P IMP RGD PMID:19451746 RGD:2312307 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Serpine1 serpin family E member 1 disease_progression IEP
ISO		 protein:increased expression:plasma (rat) RGD PMID:17446839 PMID:15257107 RGD:8547894, RGD:13208542 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinf2 serpin family F member 2 IDA protein:increased expression:plasma RGD PMID:10423332 RGD:1625538 NCBI chr10:60,770,698...60,778,782
Ensembl chr10:60,272,400...60,281,243 		JBrowse link
G Tacr1 tachykinin receptor 1 IEP mRNA,protein:increased expression:lung RGD PMID:12857498 RGD:5147821 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Tbxas1 thromboxane A synthase 1 IDA RGD PMID:9700944 RGD:1601470 NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:67,665,007...67,837,096 		JBrowse link
G Tlr2 toll-like receptor 2 IEP mRNA:increased expression:liver RGD PMID:16524509 RGD:2312724 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 IEP mRNA:increased expression:liver RGD PMID:16524509 RGD:2312724 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr9 toll-like receptor 9 IEP mRNA, protein:increased expression:pancreas (rat) RGD PMID:18376319 RGD:5130184 NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19142
    disease of anatomical entity 18455
      endocrine system disease 7039
        pancreas disease 1255
          pancreatitis 222
            acute pancreatitis 82
              acute necrotizing pancreatitis 36
paths to the root