RGD Reference Report - Overexpression of the PC3/TIS21/BTG2 mRNA is part of the stress response induced by acute pancreatitis in rats. - Rat Genome Database

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Overexpression of the PC3/TIS21/BTG2 mRNA is part of the stress response induced by acute pancreatitis in rats.

Authors: Fiedler, F  Mallo, GV  Bodeker, H  Keim, V  Dagorn, JC  Iovanna, JL 
Citation: Fiedler F, etal., Biochem Biophys Res Commun. 1998 Aug 19;249(2):562-5.
RGD ID: 2289078
Pubmed: PMID:9712737   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1998.9195   (Journal Full-text)

We have previously shown that the acute phase reaction of the pancreas is a powerful emergency mechanism which protects the organism against further pancreatic aggression. In an attempt to understand the mechanisms involved in this protective effect we tried to characterize at the molecular level the phenotypic changes of the pancreatic cell during acute stress. Using a systematic approach, we identified the PC3/TIS21/BTG2 mRNA as strongly overexpressed in pancreas during the acute phase of pancreatitis. PC3/TIS21/BTG2 mRNA is also overexpressed in liver and kidney during acute pancreatitis but not in the other tissues analyzed. In addition, PC3/TIS21/BTG2 mRNA is overexpressed in kidney after a 30-min ischemia. Since acute pancreatitis and kidney ischemia-reperfusion-induced injury were associated with apoptosis, and PC3/TIS21/BTG2 has an antiapoptotic activity, we speculate that this protein may play a role in the control of apoptosis progression in these tissues.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BTG2Humanacute necrotizing pancreatitis  ISOBtg2 (Rattus norvegicus)mRNA:increased expression:liver more ...RGD 
Btg2Ratacute necrotizing pancreatitis  IEP mRNA:increased expression:liver more ...RGD 
Btg2Mouseacute necrotizing pancreatitis  ISOBtg2 (Rattus norvegicus)mRNA:increased expression:liver more ...RGD 
BTG2HumanReperfusion Injury  ISOBtg2 (Rattus norvegicus)mRNA:increased expression:kidneyRGD 
Btg2RatReperfusion Injury  IEP mRNA:increased expression:kidneyRGD 
Btg2MouseReperfusion Injury  ISOBtg2 (Rattus norvegicus)mRNA:increased expression:kidneyRGD 

Objects Annotated

Genes (Rattus norvegicus)
Btg2  (BTG anti-proliferation factor 2)

Genes (Mus musculus)
Btg2  (BTG anti-proliferation factor 2)

Genes (Homo sapiens)
BTG2  (BTG anti-proliferation factor 2)


Additional Information