RGD Reference Report - Fat Necrosis Generates Proinflammatory Halogenated Lipids During Acute Pancreatitis. - Rat Genome Database

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Fat Necrosis Generates Proinflammatory Halogenated Lipids During Acute Pancreatitis.

Authors: Franco-Pons, N  Casas, J  Fabrias, G  Gea-Sorli, S  De-Madaria, E  Gelpi, E  Closa, D 
Citation: Franco-Pons N, etal., Ann Surg. 2012 Sep 7.
RGD ID: 7204517
Pubmed: PMID:22964727   (View Abstract at PubMed)
DOI: DOI:10.1097/SLA.0b013e318269d536   (Journal Full-text)

OBJECTIVE:: To evaluate the generation of halogenated fatty acids in the areas of fat necrosis during acute pancreatitis and to evaluate the effects of these molecules on the ensuing inflammatory process. BACKGROUND:: Lipid mediators derived from adipose tissue have been implicated in the progression of acute pancreatitis, although their precise role remains unknown. METHODS:: Acute pancreatitis was induced in rats by intraductal infusion of 3.5% sodium taurocholate. Fatty acid chlorohydrins (FA-Cl) were measured in adipose tissue, ascitic fluid, and plasma by mass spectrometry. Chlorohydrins were also instilled in the rats' peritoneal cavity, and their effects on peritoneal macrophages activation and in systemic inflammation were evaluated. Finally, they have also been measured in plasma from human patients with acute pancreatitis. RESULTS:: Induced acute pancreatitis results in a substantial release not only of free fatty acids but also of the chlorohydrins of both oleic and linoleic acids from adipose tissue. In plasma, only the chlorohydrin of oleic acid was detected. Administration of 250-muM lipid chlorohydrins, which is the concentration found in ascitic fluid, induces the expression of TNFalpha and interleukin-1beta in peritoneal macrophages and increases the systemic inflammatory response in pancreatitis. Finally, increased concentrations of oleic acid chlorohydrin have been found in plasma of human patients with pancreatitis. CONCLUSIONS:: During acute pancreatitis, adipose tissue release FA-Cl, which exacerbate the systemic inflammatory response.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL1BHumanacute necrotizing pancreatitis  ISOIl1b (Rattus norvegicus)mRNA:increased expression:peritoneal macrophages (rat)RGD 
Il1bRatacute necrotizing pancreatitis  IEP mRNA:increased expression:peritoneal macrophages (rat)RGD 
Il1bMouseacute necrotizing pancreatitis  ISOIl1b (Rattus norvegicus)mRNA:increased expression:peritoneal macrophages (rat)RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Il1bRatcellular response to lipid  IEP fatty acid chlorohydrinsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)

Genes (Mus musculus)
Il1b  (interleukin 1 beta)

Genes (Homo sapiens)
IL1B  (interleukin 1 beta)


Additional Information