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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:beta-alanine
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Accession:CHEBI:16958 term browser browse the term
Definition:A naturally-occurring beta-amino acid comprising propionic acid with the amino group in the 3-position.
Synonyms:related_synonym: 3-Aminopropionic acid;   3-aminopropanoic acid;   Formula=C3H7NO2;   H-beta-Ala-OH;   InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6);   InChIKey=UCMIRNVEIXFBKS-UHFFFAOYSA-N;   SMILES=NCCC(O)=O;   bAla;   beta-aminopropionic acid;   omega-aminopropionic acid
 alt_id: CHEBI:10343;   CHEBI:12389;   CHEBI:22821;   CHEBI:41050
 xref: Beilstein:906793;   CAS:107-95-9;   DrugBank:DB03107;   Gmelin:49614;   HMDB:HMDB0000056;   KEGG:C00099;   KEGG:D07561;   KNApSAcK:C00001333;   MetaCyc:B-ALANINE;   PDBeChem:BAL;   PMID:11139233;   PMID:11850512;   PMID:12107759;   PMID:12887142;   PMID:14363188;   PMID:16934791;   PMID:18528519;   PMID:18613640;   PMID:19239140;   PMID:19955842;   PMID:20199122;   PMID:20386120;   PMID:20479615;   PMID:20994958;   PMID:22735334;   Reaxys:906793;   Wikipedia:Beta-Alanine
 cyclic_relationship: is_conjugate_acid_of CHEBI:63070;   is_tautomer_of CHEBI:57966

show annotations for term's descendants           Sort by:
 
(R)-pantothenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atoh8 atonal bHLH transcription factor 8 increases expression ISO Pantothenic Acid results in increased expression of ATOH8 mRNA CTD PMID:19397697 NCBI chr 4:100,067,341...100,099,517
Ensembl chr 4:100,067,341...100,099,517 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid] CTD PMID:24709313 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO Pantothenic Acid results in increased expression of CYP1B1 mRNA CTD PMID:19397697 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Fam43a family with sequence similarity 43, member A increases expression ISO Pantothenic Acid results in increased expression of FAM43A mRNA CTD PMID:19397697 NCBI chr11:73,676,601...73,679,003
Ensembl chr11:73,676,601...73,678,984 		JBrowse link
G Fut7 fucosyltransferase 7 decreases expression ISO Pantothenic Acid results in decreased expression of FUT7 mRNA CTD PMID:19397697 NCBI chr 3:2,637,281...2,646,497
Ensembl chr 3:2,642,531...2,646,648 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Pantothenic Acid results in increased expression of HMOX1 mRNA; Pantothenic Acid results in increased expression of HMOX1 protein CTD PMID:19397697 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hspb7 heat shock protein family B (small) member 7 increases expression ISO Pantothenic Acid results in increased expression of HSPB7 mRNA CTD PMID:19397697 NCBI chr 5:159,968,077...159,971,563
Ensembl chr 5:159,967,839...159,971,562 		JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression ISO Pantothenic Acid results in increased expression of ID1 mRNA CTD PMID:19397697 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718 		JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO Pantothenic Acid results in increased expression of ID3 mRNA CTD PMID:19397697 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions		 ISO IDH2 protein mutant form results in increased abundance of Pantothenic Acid
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Pantothenic Acid]		 CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
G Il6 interleukin 6 increases expression ISO Pantothenic Acid results in increased expression of IL6 mRNA CTD PMID:19397697 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Pantothenic Acid CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Marchf2 membrane associated ring-CH-type finger 2 increases expression ISO Pantothenic Acid results in increased expression of MARCHF2 mRNA CTD PMID:19397697 NCBI chr 7:18,559,301...18,585,351
Ensembl chr 7:18,559,205...18,585,313 		JBrowse link
G Mtres1 mitochondrial transcription rescue factor 1 increases expression ISO Pantothenic Acid results in increased expression of MTRES1 mRNA CTD PMID:19397697 NCBI chr20:48,276,101...48,294,975
Ensembl chr20:48,275,762...48,294,948 		JBrowse link
G Myb MYB proto-oncogene, transcription factor multiple interactions ISO Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of MYB protein] CTD PMID:16112698 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817 		JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor increases expression ISO Pantothenic Acid results in increased expression of MYCN mRNA CTD PMID:19397697 NCBI chr 6:38,222,554...38,228,419
Ensembl chr 6:38,222,555...38,228,379 		JBrowse link
G Nhlrc1 NHL repeat containing E3 ubiquitin protein ligase 1 increases expression ISO Pantothenic Acid results in increased expression of NHLRC1 mRNA CTD PMID:19397697 NCBI chr17:18,059,382...18,060,572
Ensembl chr17:18,059,382...18,060,572 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO [Glycerol co-treated with Succinic Acid co-treated with Glucose-6-Phosphate co-treated with Pantothenic Acid co-treated with Niacinamide] results in increased expression of NR4A1 mRNA CTD PMID:20505214 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216 		JBrowse link
G Nrep neuronal regeneration related protein increases expression ISO Pantothenic Acid results in increased expression of NREP mRNA CTD PMID:19397697 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of PIM1 protein] CTD PMID:16112698 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555 		JBrowse link
G Pou3f4 POU class 3 homeobox 4 increases expression ISO Pantothenic Acid results in increased expression of POU3F4 mRNA CTD PMID:19397697 NCBI chr  X:82,143,789...82,145,066
Ensembl chr  X:82,143,789...82,145,066 		JBrowse link
G Ptprcap protein tyrosine phosphatase, receptor type, C-associated protein increases expression ISO Pantothenic Acid results in increased expression of PTPRCAP mRNA CTD PMID:19397697 NCBI chr 1:219,403,970...219,406,129
Ensembl chr 1:219,403,970...219,406,128 		JBrowse link
G Slc51b solute carrier family 51 subunit beta increases expression ISO Pantothenic Acid results in increased expression of SLC51B mRNA CTD PMID:19397697 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986 		JBrowse link
G Slc5a6 solute carrier family 5 member 6 increases transport
multiple interactions		 EXP
ISO		 SLC5A6 results in increased transport of Pantothenic Acid
Sodium affects the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid]		 CTD PMID:9516450 PMID:10329687 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116 		JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Pantothenic Acid results in decreased expression of SOX2 mRNA CTD PMID:19397697 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545 		JBrowse link
G Tmem18 transmembrane protein 18 increases expression ISO Pantothenic Acid results in increased expression of TMEM18 mRNA CTD PMID:19397697 NCBI chr 6:49,529,228...49,534,960
Ensembl chr 6:49,529,228...49,536,648 		JBrowse link
G Zfp575 zinc finger protein 575 decreases expression ISO Pantothenic Acid results in decreased expression of ZNF575 mRNA CTD PMID:19397697 NCBI chr 1:81,447,987...81,450,156
Ensembl chr 1:81,447,987...81,450,094 		JBrowse link
dabigatran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 decreases expression ISO Dabigatran results in decreased expression of AIF1 protein CTD PMID:27397090 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Dabigatran results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489 		JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO Dabigatran results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142 		JBrowse link
G F2 coagulation factor II decreases activity ISO Dabigatran results in decreased activity of F2 protein CTD PMID:17911567 PMID:25138021 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031 		JBrowse link
G Fga fibrinogen alpha chain multiple interactions ISO Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]] CTD PMID:25138021 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763 		JBrowse link
G Fgb fibrinogen beta chain multiple interactions ISO Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]] CTD PMID:25138021 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178 		JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO Dabigatran results in increased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831 		JBrowse link
G Fgg fibrinogen gamma chain multiple interactions ISO Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]] CTD PMID:25138021 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514 		JBrowse link
G Foxc2 forkhead box C2 decreases expression ISO Dabigatran results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr19:53,044,379...53,047,081
Ensembl chr19:53,044,379...53,047,081 		JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of GDNF mRNA] CTD PMID:28585189 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Dabigatran results in decreased expression of GFAP protein CTD PMID:27397090 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Hoxb9 homeo box B9 increases expression ISO Dabigatran results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr10:84,119,772...84,124,963
Ensembl chr10:84,119,884...84,123,390 		JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO Dabigatran results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr10:89,797,011...89,817,009
Ensembl chr10:89,797,038...89,816,491 		JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase increases expression ISO Dabigatran results in increased expression of MERTK mRNA CTD PMID:27397090 NCBI chr 3:121,235,230...121,340,932
Ensembl chr 3:121,235,119...121,342,444 		JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Dabigatran results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:231,962,517...231,963,441
Ensembl chr 2:231,962,517...231,963,308 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of NR4A2 mRNA] CTD PMID:28585189 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159 		JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO Dabigatran results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,797,766...14,799,835
Ensembl chr 1:14,797,766...14,799,835 		JBrowse link
G Pax3 paired box 3 decreases expression ISO Dabigatran results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172 		JBrowse link
G Pax6 paired box 6 increases expression ISO Dabigatran results in increased expression of PAX6 mRNA CTD PMID:31711903 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624 		JBrowse link
G Plp1 proteolipid protein 1 increases expression ISO Dabigatran results in increased expression of PLP1 mRNA CTD PMID:27397090 NCBI chr  X:107,494,326...107,511,355
Ensembl chr  X:107,496,072...107,511,348 		JBrowse link
G Rcor2 REST corepressor 2 multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of RCOR2 mRNA] CTD PMID:28585189 NCBI chr 1:222,513,970...222,525,356
Ensembl chr 1:222,519,615...222,524,779 		JBrowse link
G Ret ret proto-oncogene multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of RET protein] CTD PMID:28585189 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of SLC18A2 mRNA] CTD PMID:28585189 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148 		JBrowse link
G Snca synuclein alpha multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in increased expression of SNCA mRNA] CTD PMID:28585189 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285 		JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO Dabigatran results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:147,643,250...147,649,511
Ensembl chr 3:147,643,250...147,649,504 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of TH mRNA] CTD PMID:28585189 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in increased expression of TNF mRNA] CTD PMID:28585189 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Uncx UNC homeobox decreases expression ISO Dabigatran results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr12:17,182,158...17,186,679
Ensembl chr12:17,182,163...17,186,679 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        inhibitor 18301
          beta-alanine 55
            N-(2-hydroxyethyl)-beta-alanine 0
            N-[4-(1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-ylcarbonyl)benzoyl]-beta-alanine 0
            N-methyl-beta-alanine + 0
            beta-alanine derivative + 55
            beta-alanyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        amino acid 14108
                                          non-proteinogenic amino acid 1807
                                            beta-amino acid 187
                                              beta-alanine 55
                                                N-(2-hydroxyethyl)-beta-alanine 0
                                                N-[4-(1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-ylcarbonyl)benzoyl]-beta-alanine 0
                                                N-methyl-beta-alanine + 0
                                                beta-alanine derivative + 55
                                                beta-alanyl-CoA 0
paths to the root