CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: beta-alanine
Accession: CHEBI:16958
browse the term
Definition: A naturally-occurring beta-amino acid comprising propionic acid with the amino group in the 3-position.
Synonyms: related_synonym: 3-Aminopropionic acid; 3-aminopropanoic acid; Formula=C3H7NO2; H-beta-Ala-OH; InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6); InChIKey=UCMIRNVEIXFBKS-UHFFFAOYSA-N; SMILES=NCCC(O)=O; bAla; beta-aminopropionic acid; omega-aminopropionic acid
alt_id: CHEBI:10343; CHEBI:12389; CHEBI:22821; CHEBI:41050
xref: Beilstein:906793; CAS:107-95-9; DrugBank:DB03107; Gmelin:49614; HMDB:HMDB0000056; KEGG:C00099; KEGG:D07561; KNApSAcK:C00001333; MetaCyc:B-ALANINE; PDBeChem:BAL; PMID:11139233; PMID:11850512; PMID:12107759; PMID:12887142; PMID:14363188; PMID:16934791; PMID:18528519; PMID:18613640; PMID:19239140; PMID:19955842; PMID:20199122; PMID:20386120; PMID:20479615; PMID:20994958; PMID:22735334; Reaxys:906793; Wikipedia:Beta-Alanine
cyclic_relationship: is_conjugate_acid_of CHEBI:63070; is_tautomer_of CHEBI:57966
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Atoh8
atonal bHLH transcription factor 8
increases expression
ISO
Pantothenic Acid results in increased expression of ATOH8 mRNA
CTD
PMID:19397697
NCBI chr 4:100,067,341...100,099,517
Ensembl chr 4:100,067,341...100,099,517
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Col2a1
collagen type II alpha 1 chain
multiple interactions
EXP
[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]
CTD
PMID:24709313
NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
ISO
Pantothenic Acid results in increased expression of CYP1B1 mRNA
CTD
PMID:19397697
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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Fam43a
family with sequence similarity 43, member A
increases expression
ISO
Pantothenic Acid results in increased expression of FAM43A mRNA
CTD
PMID:19397697
NCBI chr11:73,676,601...73,679,003
Ensembl chr11:73,676,601...73,678,984
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Fut7
fucosyltransferase 7
decreases expression
ISO
Pantothenic Acid results in decreased expression of FUT7 mRNA
CTD
PMID:19397697
NCBI chr 3:2,637,281...2,646,497
Ensembl chr 3:2,642,531...2,646,648
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Hmox1
heme oxygenase 1
increases expression
ISO
Pantothenic Acid results in increased expression of HMOX1 mRNA; Pantothenic Acid results in increased expression of HMOX1 protein
CTD
PMID:19397697
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Hspb7
heat shock protein family B (small) member 7
increases expression
ISO
Pantothenic Acid results in increased expression of HSPB7 mRNA
CTD
PMID:19397697
NCBI chr 5:159,968,077...159,971,563
Ensembl chr 5:159,967,839...159,971,562
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Id1
inhibitor of DNA binding 1, HLH protein
increases expression
ISO
Pantothenic Acid results in increased expression of ID1 mRNA
CTD
PMID:19397697
NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
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Id3
inhibitor of DNA binding 3, HLH protein
increases expression
ISO
Pantothenic Acid results in increased expression of ID3 mRNA
CTD
PMID:19397697
NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
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Idh2
isocitrate dehydrogenase (NADP(+)) 2
increases abundance multiple interactions
ISO
IDH2 protein mutant form results in increased abundance of Pantothenic Acid Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Pantothenic Acid]
CTD
PMID:27469509
NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
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Il6
interleukin 6
increases expression
ISO
Pantothenic Acid results in increased expression of IL6 mRNA
CTD
PMID:19397697
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Lepr
leptin receptor
affects abundance
ISO
LEPR affects the abundance of Pantothenic Acid
CTD
PMID:20567778
NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
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Marchf2
membrane associated ring-CH-type finger 2
increases expression
ISO
Pantothenic Acid results in increased expression of MARCHF2 mRNA
CTD
PMID:19397697
NCBI chr 7:18,559,301...18,585,351
Ensembl chr 7:18,559,205...18,585,313
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Mtres1
mitochondrial transcription rescue factor 1
increases expression
ISO
Pantothenic Acid results in increased expression of MTRES1 mRNA
CTD
PMID:19397697
NCBI chr20:48,276,101...48,294,975
Ensembl chr20:48,275,762...48,294,948
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Myb
MYB proto-oncogene, transcription factor
multiple interactions
ISO
Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of MYB protein]
CTD
PMID:16112698
NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
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Mycn
MYCN proto-oncogene, bHLH transcription factor
increases expression
ISO
Pantothenic Acid results in increased expression of MYCN mRNA
CTD
PMID:19397697
NCBI chr 6:38,222,554...38,228,419
Ensembl chr 6:38,222,555...38,228,379
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Nhlrc1
NHL repeat containing E3 ubiquitin protein ligase 1
increases expression
ISO
Pantothenic Acid results in increased expression of NHLRC1 mRNA
CTD
PMID:19397697
NCBI chr17:18,059,382...18,060,572
Ensembl chr17:18,059,382...18,060,572
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
multiple interactions
ISO
[Glycerol co-treated with Succinic Acid co-treated with Glucose-6-Phosphate co-treated with Pantothenic Acid co-treated with Niacinamide] results in increased expression of NR4A1 mRNA
CTD
PMID:20505214
NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
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Nrep
neuronal regeneration related protein
increases expression
ISO
Pantothenic Acid results in increased expression of NREP mRNA
CTD
PMID:19397697
NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
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Pim1
Pim-1 proto-oncogene, serine/threonine kinase
multiple interactions
ISO
Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of PIM1 protein]
CTD
PMID:16112698
NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
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Pou3f4
POU class 3 homeobox 4
increases expression
ISO
Pantothenic Acid results in increased expression of POU3F4 mRNA
CTD
PMID:19397697
NCBI chr X:82,143,789...82,145,066
Ensembl chr X:82,143,789...82,145,066
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Ptprcap
protein tyrosine phosphatase, receptor type, C-associated protein
increases expression
ISO
Pantothenic Acid results in increased expression of PTPRCAP mRNA
CTD
PMID:19397697
NCBI chr 1:219,403,970...219,406,129
Ensembl chr 1:219,403,970...219,406,128
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Slc51b
solute carrier family 51 subunit beta
increases expression
ISO
Pantothenic Acid results in increased expression of SLC51B mRNA
CTD
PMID:19397697
NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
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Slc5a6
solute carrier family 5 member 6
increases transport multiple interactions
EXP ISO
SLC5A6 results in increased transport of Pantothenic Acid Sodium affects the reaction [SLC5A6 results in increased transport of Pantothenic Acid] Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
CTD
PMID:9516450 PMID:10329687
NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
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Sox2
SRY-box transcription factor 2
decreases expression
ISO
Pantothenic Acid results in decreased expression of SOX2 mRNA
CTD
PMID:19397697
NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
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Tmem18
transmembrane protein 18
increases expression
ISO
Pantothenic Acid results in increased expression of TMEM18 mRNA
CTD
PMID:19397697
NCBI chr 6:49,529,228...49,534,960
Ensembl chr 6:49,529,228...49,536,648
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Zfp575
zinc finger protein 575
decreases expression
ISO
Pantothenic Acid results in decreased expression of ZNF575 mRNA
CTD
PMID:19397697
NCBI chr 1:81,447,987...81,450,156
Ensembl chr 1:81,447,987...81,450,094
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Aif1
allograft inflammatory factor 1
decreases expression
ISO
Dabigatran results in decreased expression of AIF1 protein
CTD
PMID:27397090
NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
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Aldh1a2
aldehyde dehydrogenase 1 family, member A2
decreases expression
ISO
Dabigatran results in decreased expression of ALDH1A2 mRNA
CTD
PMID:31711903
NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
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Eya1
EYA transcriptional coactivator and phosphatase 1
decreases expression
ISO
Dabigatran results in decreased expression of EYA1 mRNA
CTD
PMID:31711903
NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142
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F2
coagulation factor II
decreases activity
ISO
Dabigatran results in decreased activity of F2 protein
CTD
PMID:17911567 PMID:25138021
NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
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Fga
fibrinogen alpha chain
multiple interactions
ISO
Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]]
CTD
PMID:25138021
NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
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Fgb
fibrinogen beta chain
multiple interactions
ISO
Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]]
CTD
PMID:25138021
NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
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Fgf8
fibroblast growth factor 8
increases expression
ISO
Dabigatran results in increased expression of FGF8 mRNA
CTD
PMID:31711903
NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831
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Fgg
fibrinogen gamma chain
multiple interactions
ISO
Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]]
CTD
PMID:25138021
NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
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Foxc2
forkhead box C2
decreases expression
ISO
Dabigatran results in decreased expression of FOXC2 mRNA
CTD
PMID:31711903
NCBI chr19:53,044,379...53,047,081
Ensembl chr19:53,044,379...53,047,081
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Gdnf
glial cell derived neurotrophic factor
multiple interactions
EXP
Dabigatran inhibits the reaction [Rotenone results in decreased expression of GDNF mRNA]
CTD
PMID:28585189
NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
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Gfap
glial fibrillary acidic protein
decreases expression
ISO
Dabigatran results in decreased expression of GFAP protein
CTD
PMID:27397090
NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
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Hoxb9
homeo box B9
increases expression
ISO
Dabigatran results in increased expression of HOXB9 mRNA
CTD
PMID:31711903
NCBI chr10:84,119,772...84,124,963
Ensembl chr10:84,119,884...84,123,390
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Meox1
mesenchyme homeobox 1
decreases expression
ISO
Dabigatran results in decreased expression of MEOX1 mRNA
CTD
PMID:31711903
NCBI chr10:89,797,011...89,817,009
Ensembl chr10:89,797,038...89,816,491
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Mertk
MER proto-oncogene, tyrosine kinase
increases expression
ISO
Dabigatran results in increased expression of MERTK mRNA
CTD
PMID:27397090
NCBI chr 3:121,235,230...121,340,932
Ensembl chr 3:121,235,119...121,342,444
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Neurog2
neurogenin 2
increases expression
ISO
Dabigatran results in increased expression of NEUROG2 mRNA
CTD
PMID:31711903
NCBI chr 2:231,962,517...231,963,441
Ensembl chr 2:231,962,517...231,963,308
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Nr4a2
nuclear receptor subfamily 4, group A, member 2
multiple interactions
EXP
Dabigatran inhibits the reaction [Rotenone results in decreased expression of NR4A2 mRNA]
CTD
PMID:28585189
NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
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Olig3
oligodendrocyte transcription factor 3
increases expression
ISO
Dabigatran results in increased expression of OLIG3 mRNA
CTD
PMID:31711903
NCBI chr 1:14,797,766...14,799,835
Ensembl chr 1:14,797,766...14,799,835
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Pax3
paired box 3
decreases expression
ISO
Dabigatran results in decreased expression of PAX3 mRNA
CTD
PMID:31711903
NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172
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Pax6
paired box 6
increases expression
ISO
Dabigatran results in increased expression of PAX6 mRNA
CTD
PMID:31711903
NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624
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Plp1
proteolipid protein 1
increases expression
ISO
Dabigatran results in increased expression of PLP1 mRNA
CTD
PMID:27397090
NCBI chr X:107,494,326...107,511,355
Ensembl chr X:107,496,072...107,511,348
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Rcor2
REST corepressor 2
multiple interactions
EXP
Dabigatran inhibits the reaction [Rotenone results in decreased expression of RCOR2 mRNA]
CTD
PMID:28585189
NCBI chr 1:222,513,970...222,525,356
Ensembl chr 1:222,519,615...222,524,779
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Ret
ret proto-oncogene
multiple interactions
EXP
Dabigatran inhibits the reaction [Rotenone results in decreased expression of RET protein]
CTD
PMID:28585189
NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
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Slc18a2
solute carrier family 18 member A2
multiple interactions
EXP
Dabigatran inhibits the reaction [Rotenone results in decreased expression of SLC18A2 mRNA]
CTD
PMID:28585189
NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
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Snca
synuclein alpha
multiple interactions
EXP
Dabigatran inhibits the reaction [Rotenone results in increased expression of SNCA mRNA]
CTD
PMID:28585189
NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
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Tcf15
transcription factor 15
decreases expression
ISO
Dabigatran results in decreased expression of TCF15 mRNA
CTD
PMID:31711903
NCBI chr 3:147,643,250...147,649,511
Ensembl chr 3:147,643,250...147,649,504
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Th
tyrosine hydroxylase
multiple interactions
EXP
Dabigatran inhibits the reaction [Rotenone results in decreased expression of TH mRNA]
CTD
PMID:28585189
NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
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Tnf
tumor necrosis factor
multiple interactions
EXP
Dabigatran inhibits the reaction [Rotenone results in increased expression of TNF mRNA]
CTD
PMID:28585189
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Uncx
UNC homeobox
decreases expression
ISO
Dabigatran results in decreased expression of UNCX mRNA
CTD
PMID:31711903
NCBI chr12:17,182,158...17,186,679
Ensembl chr12:17,182,163...17,186,679
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19770
role
19720
biological role
19720
inhibitor
18301
beta-alanine
55
N-(2-hydroxyethyl)-beta-alanine
0
N-[4-(1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-ylcarbonyl)benzoyl]-beta-alanine
0
N-methyl-beta-alanine +
0
beta-alanine derivative +
55
beta-alanyl-CoA
0
Path 2
CHEBI ontology
19770
subatomic particle
19768
composite particle
19768
hadron
19768
baryon
19768
nucleon
19768
atomic nucleus
19768
atom
19768
main group element atom
19662
p-block element atom
19662
carbon group element atom
19580
carbon atom
19571
organic molecular entity
19571
organic group
18602
organic divalent group
18593
organodiyl group
18593
carbonyl group
18506
carbonyl compound
18506
carboxylic acid
18158
amino acid
14108
non-proteinogenic amino acid
1807
beta-amino acid
187
beta-alanine
55
N-(2-hydroxyethyl)-beta-alanine
0
N-[4-(1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-ylcarbonyl)benzoyl]-beta-alanine
0
N-methyl-beta-alanine +
0
beta-alanine derivative +
55
beta-alanyl-CoA
0