Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:NSC 23766
go back to main search page
Accession:CHEBI:144984 term browser browse the term
Definition:An aminopyrimidine that is 6-methylpyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 5-(diethylamino)pentan-2-yl and 4-amino-2-methylquinolin-6-yl groups respectively. An inhibitor of the signalling G-protein known as RAC1 (Ras-related C3 botulinum toxin substrate 1).
Synonyms:exact_synonym: N(6)-(2-{[5-(diethylamino)pentan-2-yl]amino}-6-methylpyrimidin-4-yl)-2-methylquinoline-4,6-diamine
 related_synonym: Formula=C24H35N7;   InChI=1S/C24H35N7/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);   InChIKey=DEFBCZWQLILOJF-UHFFFAOYSA-N;   N6-[2-[5-(diethylamino)pentan-2-ylamino]-6-methyl-4-pyrimidinyl]-2-methylquinoline-4,6-diamine;   NSC23766;   SMILES=CC(CCCN(CC)CC)NC1=NC(=CC(NC2=CC=3C(=NC(=CC3N)C)C=C2)=N1)C
 alt_id: CHEBI:91883
 xref: LINCS:LSM-1818
 xref_mesh: MESH:C487513
 xref: PMID:15128949 "Europe PMC";   PMID:18183417 "Europe PMC";   PMID:19052208 "Europe PMC";   PMID:19491337 "Europe PMC";   PMID:20515940 "Europe PMC";   PMID:21511011 "Europe PMC";   PMID:23887096 "Europe PMC";   PMID:24257023 "Europe PMC";   PMID:24523909 "Europe PMC";   PMID:24953831 "Europe PMC";   PMID:25154784 "Europe PMC";   PMID:25319697 "Europe PMC";   PMID:25628054 "Europe PMC";   PMID:25631101 "Europe PMC";   PMID:27467102 "Europe PMC";   PMID:29050986 "Europe PMC";   PMID:30871916 "Europe PMC"


show annotations for term's descendants       view all columns           Sort by:
 
NSC 23766 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:6480464
G Cd47 Cd47 molecule JBrowse link 11 53,511,485 53,575,754 RGD:6480464
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Map3k11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 1 221,043,119 221,056,420 RGD:6480464
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:6480464
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6480464
G Mmp3 matrix metallopeptidase 3 JBrowse link 8 5,676,608 5,698,579 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:6480464
G Pecam1 platelet and endothelial cell adhesion molecule 1 JBrowse link 10 94,850,971 94,913,202 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6480464
G Rac2 Rac family small GTPase 2 JBrowse link 7 119,769,708 119,797,111 RGD:6480464
G Rhob ras homolog family member B JBrowse link 6 33,689,127 33,691,301 RGD:6480464
G Sirpa signal-regulatory protein alpha JBrowse link 3 122,113,735 122,152,478 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      biological role 19596
        antimicrobial agent 17143
          antiviral agent 3604
            NSC 23766 27
              NSC 23766 trihydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    main group molecular entity 19531
                      s-block molecular entity 19314
                        hydrogen molecular entity 19303
                          hydrides 18231
                            inorganic hydride 17095
                              pnictogen hydride 17053
                                nitrogen hydride 16874
                                  azane 16551
                                    ammonia 16548
                                      organic amino compound 16547
                                        aromatic amine 13576
                                          aminopyrimidine 1042
                                            NSC 23766 27
                                              NSC 23766 trihydrochloride 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.