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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:NSC 23766
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Accession:CHEBI:144984 term browser browse the term
Definition:An aminopyrimidine that is 6-methylpyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 5-(diethylamino)pentan-2-yl and 4-amino-2-methylquinolin-6-yl groups respectively. An inhibitor of the signalling G-protein known as RAC1 (Ras-related C3 botulinum toxin substrate 1).
Synonyms:exact_synonym: N(6)-(2-{[5-(diethylamino)pentan-2-yl]amino}-6-methylpyrimidin-4-yl)-2-methylquinoline-4,6-diamine
 related_synonym: Formula=C24H35N7;   InChI=1S/C24H35N7/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);   InChIKey=DEFBCZWQLILOJF-UHFFFAOYSA-N;   N6-[2-[5-(diethylamino)pentan-2-ylamino]-6-methyl-4-pyrimidinyl]-2-methylquinoline-4,6-diamine;   NSC23766;   SMILES=CC(CCCN(CC)CC)NC1=NC(=CC(NC2=CC=3C(=NC(=CC3N)C)C=C2)=N1)C
 alt_id: CHEBI:91883
 xref: LINCS:LSM-1818
 xref_mesh: MESH:C487513
 xref: PMID:15128949;   PMID:18183417;   PMID:19052208;   PMID:19491337;   PMID:20515940;   PMID:21511011;   PMID:23887096;   PMID:24257023;   PMID:24523909;   PMID:24953831;   PMID:25154784;   PMID:25319697;   PMID:25628054;   PMID:25631101;   PMID:27467102;   PMID:29050986;   PMID:30871916


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NSC 23766 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO NSC 23766 inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein] CTD PMID:31018152 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]] CTD PMID:28268219 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions ISO NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]] CTD PMID:28268219 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of CCN2 mRNA] CTD PMID:28710503 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cd47 Cd47 molecule multiple interactions ISO NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]]; NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium] CTD PMID:28268219 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175
JBrowse link
G Cdc42 cell division cycle 42 multiple interactions ISO NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]] CTD PMID:22166487 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO NSC 23766 affects the expression of DDIT3 protein CTD PMID:27351882 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of GPX1 mRNA] CTD PMID:28710503 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form] CTD PMID:28710503 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of HMOX1 mRNA] CTD PMID:28710503 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO NSC 23766 inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of ICAM1] CTD PMID:19632255, PMID:22166487 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; NSC 23766 inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; NSC 23766 inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein] CTD PMID:21511011, PMID:31018152 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA] CTD PMID:28710503 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO NSC 23766 inhibits the reaction [Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein] CTD PMID:22166487 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 multiple interactions ISO NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of MAP3K11 protein] CTD PMID:22166487 NCBI chr 1:221,043,119...221,056,420
Ensembl chr 1:221,043,119...221,056,417
JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of MFN2 mRNA] CTD PMID:28710503 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein] CTD PMID:18625914 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA] CTD PMID:28710503 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:21511011 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of NFE2L2 mRNA] CTD PMID:28710503 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nppa natriuretic peptide A multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of NPPA mRNA] CTD PMID:28710503 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO NSC 23766 inhibits the reaction [sodium arsenite results in increased expression of PECAM1 protein] CTD PMID:19033667 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of PPARGC1A mRNA] CTD PMID:28710503 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions
decreases activity
ISO NSC 23766 inhibits the reaction [sodium arsenite results in increased activity of RAC1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]]
NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]; NSC 23766 inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of RAC1 protein]
NSC 23766 results in decreased activity of RAC1 protein
CTD PMID:19349368, PMID:21511011, PMID:22166487, PMID:28710503, PMID:31018152 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rac2 Rac family small GTPase 2 multiple interactions ISO NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased activity of RAC2 protein] CTD PMID:21511011 NCBI chr 7:119,769,708...119,797,111
Ensembl chr 7:119,783,849...119,797,098
JBrowse link
G Rhob ras homolog family member B multiple interactions ISO NSC 23766 inhibits the reaction [cytotoxic necrotizing factor type 1 results in increased expression of RHOB mRNA] CTD PMID:23732113 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Sirpa signal-regulatory protein alpha multiple interactions ISO NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]]; NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium] CTD PMID:28268219 NCBI chr 3:122,113,735...122,152,478
Ensembl chr 3:122,114,108...122,152,477
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:21511011 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO NSC 23766 inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein] CTD PMID:19632255 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        antimicrobial agent 17329
          antiviral agent 10253
            NSC 23766 29
              NSC 23766 trihydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    main group molecular entity 19696
                      s-block molecular entity 19456
                        hydrogen molecular entity 19447
                          hydrides 18703
                            inorganic hydride 17433
                              pnictogen hydride 17405
                                nitrogen hydride 17247
                                  azane 16964
                                    ammonia 16963
                                      organic amino compound 16962
                                        aromatic amine 13633
                                          aminopyrimidine 1107
                                            NSC 23766 29
                                              NSC 23766 trihydrochloride 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.