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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:NSC 23766
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Accession:CHEBI:144984 term browser browse the term
Definition:An aminopyrimidine that is 6-methylpyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 5-(diethylamino)pentan-2-yl and 4-amino-2-methylquinolin-6-yl groups respectively. An inhibitor of the signalling G-protein known as RAC1 (Ras-related C3 botulinum toxin substrate 1).
Synonyms:exact_synonym: N(6)-(2-{[5-(diethylamino)pentan-2-yl]amino}-6-methylpyrimidin-4-yl)-2-methylquinoline-4,6-diamine
 related_synonym: Formula=C24H35N7;   InChI=1S/C24H35N7/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);   InChIKey=DEFBCZWQLILOJF-UHFFFAOYSA-N;   N6-[2-[5-(diethylamino)pentan-2-ylamino]-6-methyl-4-pyrimidinyl]-2-methylquinoline-4,6-diamine;   NSC23766;   SMILES=CC(CCCN(CC)CC)NC1=NC(=CC(NC2=CC=3C(=NC(=CC3N)C)C=C2)=N1)C
 alt_id: CHEBI:91883
 xref: LINCS:LSM-1818
 xref_mesh: MESH:C487513
 xref: PMID:15128949;   PMID:18183417;   PMID:19052208;   PMID:19491337;   PMID:20515940;   PMID:21511011;   PMID:23887096;   PMID:24257023;   PMID:24523909;   PMID:24953831;   PMID:25154784;   PMID:25319697;   PMID:25628054;   PMID:25631101;   PMID:27467102;   PMID:29050986;   PMID:30871916


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NSC 23766 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO NSC 23766 inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein] CTD PMID:31018152 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]] CTD PMID:28268219 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]] CTD PMID:28268219 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases secretion ISO NSC 23766 results in decreased secretion of CCL2 protein CTD PMID:36009428 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases secretion ISO NSC 23766 results in decreased secretion of CCL3 protein CTD PMID:36009428 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases secretion ISO NSC 23766 results in decreased secretion of CCL4 protein CTD PMID:36009428 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of CCN2 mRNA] CTD PMID:28710503 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Cd47 Cd47 molecule multiple interactions ISO NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]]; NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium] CTD PMID:28268219 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425 		JBrowse link
G Cdc42 cell division cycle 42 multiple interactions ISO NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]] CTD PMID:22166487 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO NSC 23766 affects the expression of DDIT3 protein CTD PMID:27351882 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 affects response to substance ISO FLT3 protein affects the susceptibility to NSC 23766 CTD PMID:36009428 NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of GPX1 mRNA] CTD PMID:28710503 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form] CTD PMID:28710503 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hgf hepatocyte growth factor decreases secretion ISO NSC 23766 results in decreased secretion of HGF protein CTD PMID:36009428 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of HMOX1 mRNA] CTD PMID:28710503 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO NSC 23766 inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of ICAM1] CTD PMID:19632255 PMID:22166487 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; NSC 23766 inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; NSC 23766 inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein] CTD PMID:21511011 PMID:31018152 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA] CTD PMID:28710503 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO NSC 23766 inhibits the reaction [Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein] CTD PMID:22166487 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 multiple interactions ISO NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of MAP3K11 protein] CTD PMID:22166487 NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of MFN2 mRNA] CTD PMID:28710503 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
decreases secretion		 ISO NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]
NSC 23766 results in decreased secretion of MMP1 protein		 CTD PMID:18625914 PMID:36009428 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA] CTD PMID:28710503 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:21511011 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of NFE2L2 mRNA] CTD PMID:28710503 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Npm1 nucleophosmin 1 affects response to substance ISO NPM1 protein affects the susceptibility to NSC 23766 CTD PMID:36009428 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645 		JBrowse link
G Nppa natriuretic peptide A multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of NPPA mRNA] CTD PMID:28710503 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO NSC 23766 inhibits the reaction [sodium arsenite results in increased expression of PECAM1 protein] CTD PMID:19033667 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of PPARGC1A mRNA] CTD PMID:28710503 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions
decreases activity		 ISO NSC 23766 inhibits the reaction [sodium arsenite results in increased activity of RAC1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]]
NSC 23766 results in decreased activity of RAC1 protein
NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]; NSC 23766 inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of RAC1 protein]		 CTD PMID:19349368 PMID:21511011 PMID:22166487 PMID:28710503 PMID:31018152 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rac2 Rac family small GTPase 2 multiple interactions ISO NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased activity of RAC2 protein] CTD PMID:21511011 NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720 		JBrowse link
G Rhob ras homolog family member B multiple interactions ISO NSC 23766 inhibits the reaction [cytotoxic necrotizing factor type 1 results in increased expression of RHOB mRNA] CTD PMID:23732113 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108 		JBrowse link
G Serpine1 serpin family E member 1 decreases secretion ISO NSC 23766 results in decreased secretion of SERPINE1 protein CTD PMID:36009428 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sirpa signal-regulatory protein alpha multiple interactions ISO NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]]; NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium] CTD PMID:28268219 NCBI chr 3:116,819,730...116,858,099
Ensembl chr 3:116,819,726...116,858,098 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion		 ISO NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
NSC 23766 results in decreased secretion of TNF protein		 CTD PMID:21511011 PMID:36009428 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO NSC 23766 inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein] CTD PMID:19632255 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        antimicrobial agent 18104
          antiviral agent 11061
            NSC 23766 36
              NSC 23766 trihydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    main group molecular entity 19759
                      s-block molecular entity 19628
                        hydrogen molecular entity 19614
                          hydrides 19087
                            inorganic hydride 18091
                              pnictogen hydride 18080
                                nitrogen hydride 17987
                                  azane 17796
                                    ammonia 17795
                                      organic amino compound 17795
                                        aromatic amine 15398
                                          aminopyrimidine 1927
                                            NSC 23766 36
                                              NSC 23766 trihydrochloride 0
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