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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diminazene(2+)
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Accession:CHEBI:82614 term browser browse the term
Definition:A carboxamidinium ion resulting from the protonation of both of the amidino groups of diminazene. The major species at pH 7.3.
Synonyms:exact_synonym: (triaz-1-ene-1,3-diyldi-4,1-phenylene)bis(iminomethanaminium)
 related_synonym: Formula=C14H17N7;   InChI=1S/C14H15N7/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)(H,19,20)/p+2;   InChIKey=XNYZHCFCZNMTFY-UHFFFAOYSA-P;   SMILES=NC(=[NH2+])c1ccc(NN=Nc2ccc(cc2)C(N)=[NH2+])cc1
 xref: PMID:7902657
 cyclic_relationship: is_conjugate_acid_of CHEBI:81724


show annotations for term's descendants           Sort by:
diminazene diaceturate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 increases expression
multiple interactions
increases activity		 ISO
EXP		 diminazene aceturate results in increased expression of ACE2 mRNA; diminazene aceturate results in increased expression of ACE2 protein
PD 123319 inhibits the reaction [diminazene aceturate results in increased expression of ACE2 protein]
diminazene aceturate results in increased activity of ACE2 protein
[Lipopolysaccharides co-treated with diminazene aceturate] results in increased expression of ACE2 mRNA; [Lipopolysaccharides co-treated with diminazene aceturate] results in increased expression of ACE2 protein; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR1 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ACE2 protein affects the reaction [diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]]		 CTD PMID:25301841 PMID:26862037 PMID:27550926 PMID:28688122 PMID:31982938 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression ISO diminazene aceturate results in decreased expression of ACTA2 protein CTD PMID:29977014 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen increases expression
multiple interactions		 ISO diminazene aceturate results in increased expression of AGT protein modified form
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]]; ACE2 protein affects the reaction [diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]; diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]
diminazene aceturate results in increased expression of AGT protein alternative form		 CTD PMID:25301841 PMID:26862037 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR1 mRNA]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR1 mRNA] CTD PMID:26862037 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G App amyloid beta precursor protein affects expression ISO diminazene aceturate affects the expression of APP protein alternative form CTD PMID:31982938 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Aurka aurora kinase A decreases expression ISO diminazene aceturate results in decreased expression of AURKA mRNA CTD PMID:37681557 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Casp3 caspase 3 increases activity ISO diminazene aceturate results in increased activity of CASP3 protein CTD PMID:37681557 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions		 ISO diminazene aceturate results in decreased expression of MCP1 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]		 CTD PMID:26862037 PMID:29977014 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO diminazene aceturate results in decreased expression of CCNA2 mRNA CTD PMID:37681557 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO diminazene aceturate results in decreased expression of CDC25A mRNA CTD PMID:37681557 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO diminazene aceturate results in decreased expression of COL1A1 protein CTD PMID:29977014 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression ISO diminazene aceturate results in decreased expression of CYBB protein CTD PMID:29977014 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Foxm1 forkhead box M1 decreases expression ISO diminazene aceturate results in decreased expression of FOXM1 mRNA CTD PMID:37681557 NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) decreases expression ISO diminazene aceturate results in decreased expression of FURIN mRNA CTD PMID:37681557 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B increases phosphorylation ISO diminazene aceturate results in increased phosphorylation of GRIN2B protein CTD PMID:31982938 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP
ISO		 diminazene aceturate results in decreased expression of IL1B mRNA
diminazene aceturate results in decreased expression of IL1B protein		 CTD PMID:25883526 PMID:31982938 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 ISO
EXP		 diminazene aceturate results in decreased expression of IL6 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]		 CTD PMID:25883526 PMID:26862037 PMID:29977014 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO diminazene aceturate results in increased phosphorylation of MAPK1 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]		 CTD PMID:26862037 PMID:31982938 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases phosphorylation EXP diminazene aceturate results in decreased phosphorylation of MAPK14 protein CTD PMID:25883526 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO diminazene aceturate results in increased phosphorylation of MAPK3 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]		 CTD PMID:26862037 PMID:31982938 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor increases expression ISO diminazene aceturate results in increased expression of MAS1 protein CTD PMID:31982938 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO diminazene aceturate results in decreased expression of MCM3 mRNA CTD PMID:37681557 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO diminazene aceturate results in decreased expression of MKI67 mRNA CTD PMID:37681557 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO diminazene aceturate results in decreased expression of MYC mRNA CTD PMID:37681557 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression ISO diminazene aceturate results in decreased expression of NCF1 protein CTD PMID:29977014 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 decreases transport ISO diminazene aceturate results in decreased transport of NCF2 protein CTD PMID:29977014 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:26862037 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos1 nitric oxide synthase 1 decreases expression EXP diminazene aceturate results in decreased expression of NOS1 mRNA CTD PMID:25883526 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nox1 NADPH oxidase 1 decreases expression ISO diminazene aceturate results in decreased expression of NOX1 protein CTD PMID:29977014 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO diminazene aceturate results in decreased expression of PCNA mRNA CTD PMID:37681557 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Plk1 polo-like kinase 1 decreases expression ISO diminazene aceturate results in decreased expression of PLK1 mRNA CTD PMID:37681557 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Plk4 polo-like kinase 4 decreases expression ISO diminazene aceturate results in decreased expression of PLK4 mRNA CTD PMID:37681557 NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity
decreases expression		 EXP diminazene aceturate results in decreased activity of RELA protein
diminazene aceturate results in decreased expression of RELA mRNA; diminazene aceturate results in decreased expression of RELA protein		 CTD PMID:25883526 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Smad2 SMAD family member 2 decreases phosphorylation ISO diminazene aceturate results in decreased phosphorylation of SMAD2 protein CTD PMID:29977014 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 decreases phosphorylation ISO diminazene aceturate results in decreased phosphorylation of SMAD3 protein CTD PMID:29977014 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Tnf tumor necrosis factor decreases expression
decreases secretion		 EXP
ISO		 diminazene aceturate results in decreased expression of TNF mRNA; diminazene aceturate results in decreased expression of TNF protein
diminazene aceturate results in decreased secretion of TNF protein		 CTD PMID:25883526 PMID:29977014 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      biological role 19858
        antimicrobial agent 18239
          antimicrobial drug 11182
            antiprotozoal drug 7448
              trypanocidal drug 128
                diminazene(2+) 36
                  diminazene diaceturate 36
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon group molecular entity 19766
                          organic molecular entity 19743
                            organic ion 11453
                              organic cation 8963
                                iminium ion 98
                                  carboxamidinium ion 36
                                    diminazene(2+) 36
                                      diminazene diaceturate 36
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