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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carboxamidinium ion
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Accession:CHEBI:77718 term browser browse the term
Definition:Any iminium ion resulting from the protonation of a carboxamidine.
Synonyms:related_synonym: carboxamidinium ions


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diminazene diaceturate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 increases expression
increases activity
multiple interactions
ISO
EXP
diminazene aceturate results in increased expression of ACE2 mRNA; diminazene aceturate results in increased expression of ACE2 protein
diminazene aceturate results in increased activity of ACE2 protein
PD 123319 inhibits the reaction [diminazene aceturate results in increased expression of ACE2 protein]
CTD PMID:25301841, PMID:27550926, PMID:28688122, PMID:31982938 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression ISO diminazene aceturate results in decreased expression of ACTA2 protein CTD PMID:29977014 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agt angiotensinogen increases expression ISO diminazene aceturate results in increased expression of AGT protein modified form CTD PMID:25301841 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G App amyloid beta precursor protein affects expression ISO diminazene aceturate affects the expression of APP protein alternative form CTD PMID:31982938 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO diminazene aceturate results in decreased expression of MCP1 protein CTD PMID:29977014 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO diminazene aceturate results in decreased expression of COL1A1 protein CTD PMID:29977014 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression ISO diminazene aceturate results in decreased expression of NOX2 protein CTD PMID:29977014 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B increases phosphorylation ISO diminazene aceturate results in increased phosphorylation of GRIN2B protein CTD PMID:31982938 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP
ISO
diminazene aceturate results in decreased expression of IL1B mRNA
diminazene aceturate results in decreased expression of IL1B protein
CTD PMID:25883526, PMID:31982938 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression ISO
EXP
diminazene aceturate results in decreased expression of IL6 protein CTD PMID:25883526, PMID:29977014 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO diminazene aceturate results in increased phosphorylation of MAPK1 protein CTD PMID:31982938 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases phosphorylation EXP diminazene aceturate results in decreased phosphorylation of MAPK14 protein CTD PMID:25883526 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO diminazene aceturate results in increased phosphorylation of MAPK3 protein CTD PMID:31982938 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor increases expression ISO diminazene aceturate results in increased expression of MAS1 protein CTD PMID:31982938 NCBI chr 1:48,076,761...48,108,218
Ensembl chr 1:48,077,033...48,108,216
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression ISO diminazene aceturate results in decreased expression of NCF1 protein CTD PMID:29977014 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 decreases transport ISO diminazene aceturate results in decreased transport of NCF2 protein CTD PMID:29977014 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
JBrowse link
G Nos1 nitric oxide synthase 1 decreases expression EXP diminazene aceturate results in decreased expression of NOS1 mRNA CTD PMID:25883526 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nox1 NADPH oxidase 1 decreases expression ISO diminazene aceturate results in decreased expression of NOX1 protein CTD PMID:29977014 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity
decreases expression
EXP diminazene aceturate results in decreased activity of RELA protein
diminazene aceturate results in decreased expression of RELA mRNA; diminazene aceturate results in decreased expression of RELA protein
CTD PMID:25883526 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Smad2 SMAD family member 2 decreases phosphorylation ISO diminazene aceturate results in decreased phosphorylation of SMAD2 protein CTD PMID:29977014 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 decreases phosphorylation ISO diminazene aceturate results in decreased phosphorylation of SMAD3 protein CTD PMID:29977014 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Tnf tumor necrosis factor decreases expression
decreases secretion
EXP
ISO
diminazene aceturate results in decreased expression of TNF mRNA; diminazene aceturate results in decreased expression of TNF protein
diminazene aceturate results in decreased secretion of TNF protein
CTD PMID:25883526, PMID:29977014 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    chemical entity 19791
      molecular entity 19787
        ion 15930
          organic ion 8325
            organic cation 7142
              iminium ion 70
                carboxamidinium ion 22
                  6-[(4-aminobenzyl)amino]-2,3,4,5-tetrahydropyridinium 0
                  7-formamidino-7-deazaguanine(1+) 0
                  N(6)-acetimidoyl-L-lysinium(2+) + 0
                  diminazene(2+) + 22
                  oxymetazoline(1+) + 0
                  pentamidinium(2+) + 0
                  tipiracil(1+) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    main group molecular entity 19675
                      p-block molecular entity 19675
                        carbon group molecular entity 19571
                          organic molecular entity 19560
                            organic ion 8325
                              organic cation 7142
                                iminium ion 70
                                  carboxamidinium ion 22
                                    6-[(4-aminobenzyl)amino]-2,3,4,5-tetrahydropyridinium 0
                                    7-formamidino-7-deazaguanine(1+) 0
                                    N(6)-acetimidoyl-L-lysinium(2+) + 0
                                    diminazene(2+) + 22
                                    oxymetazoline(1+) + 0
                                    pentamidinium(2+) + 0
                                    tipiracil(1+) + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.