Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diminazene diaceturate
go back to main search page
Accession:CHEBI:82615 term browser browse the term
Definition:An N-acetylglycinate salt resulting from the reaction of diminazene with 2 mol eq. of N-acetylglycine.
Synonyms:related_synonym: (triaz-1-ene-1,3-diyldi-4,1-phenylene)bis(iminomethanaminium) bis(acetamidoacetate);   1,3-bis(4-guanylphenyl)triazene diaceturate;   1,3-bis(p-amidinophenyl)triazene bis(N-acetylglycinate);   4,4'-(diazoamino)dibenzamidine diaceturate;   4,4'-diamidinodiazoaminobenzene diaceturate;   Berenil;   Beronal;   Bevenil;   Formula=C22H29N9O6;   Ganasag;   Ganaseg;   InChI=1S/C14H15N7.2C4H7NO3/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18;2*1-3(6)5-2-4(7)8/h1-8H,(H3,15,16)(H3,17,18)(H,19,20);2*2H2,1H3,(H,5,6)(H,7,8);   InChIKey=OKQSSSVVBOUMNZ-UHFFFAOYSA-N;   SMILES=CC(=O)NCC(O)=O.CC(=O)NCC(O)=O.NC(=N)c1ccc(NN=Nc2ccc(cc2)C(N)=N)cc1;   di-(4-amidinophenyl)-triazine-(N-1,3)-diaceturate;   diminazene aceturate;   diminazene bis(N-acetylglycinate)
 xref: CAS:908-54-3;   DrugBank:DB03608
 xref_mesh: MESH:C003915
 xref: PDBeChem:BRN;   PMID:23665493;   PMID:23959549;   PMID:24476993;   PMID:24893117;   PMID:7902657;   PMID:8086477;   Patent:US2838485;   Reaxys:3841323



show annotations for term's descendants           Sort by:
diminazene diaceturate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 increases expression
multiple interactions
increases activity
ISO
EXP
diminazene aceturate results in increased expression of ACE2 mRNA; diminazene aceturate results in increased expression of ACE2 protein
PD 123319 inhibits the reaction [diminazene aceturate results in increased expression of ACE2 protein]
diminazene aceturate results in increased activity of ACE2 protein
[Lipopolysaccharides co-treated with diminazene aceturate] results in increased expression of ACE2 mRNA; [Lipopolysaccharides co-treated with diminazene aceturate] results in increased expression of ACE2 protein; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR1 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ACE2 protein affects the reaction [diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]]
CTD PMID:25301841 PMID:26862037 PMID:27550926 PMID:28688122 PMID:31982938 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression ISO diminazene aceturate results in decreased expression of ACTA2 protein CTD PMID:29977014 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Agt angiotensinogen increases expression
multiple interactions
ISO diminazene aceturate results in increased expression of AGT protein modified form
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]]; ACE2 protein affects the reaction [diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]; diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]
diminazene aceturate results in increased expression of AGT protein alternative form
CTD PMID:25301841 PMID:26862037 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR1 mRNA]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR1 mRNA] CTD PMID:26862037 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G App amyloid beta precursor protein affects expression ISO diminazene aceturate affects the expression of APP protein alternative form CTD PMID:31982938 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aurka aurora kinase A decreases expression ISO diminazene aceturate results in decreased expression of AURKA mRNA CTD PMID:37681557 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Casp3 caspase 3 increases activity ISO diminazene aceturate results in increased activity of CASP3 protein CTD PMID:37681557 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO diminazene aceturate results in decreased expression of MCP1 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]
CTD PMID:26862037 PMID:29977014 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO diminazene aceturate results in decreased expression of CCNA2 mRNA CTD PMID:37681557 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO diminazene aceturate results in decreased expression of CDC25A mRNA CTD PMID:37681557 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO diminazene aceturate results in decreased expression of COL1A1 protein CTD PMID:29977014 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression ISO diminazene aceturate results in decreased expression of CYBB protein CTD PMID:29977014 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Foxm1 forkhead box M1 decreases expression ISO diminazene aceturate results in decreased expression of FOXM1 mRNA CTD PMID:37681557 NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) decreases expression ISO diminazene aceturate results in decreased expression of FURIN mRNA CTD PMID:37681557 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B increases phosphorylation ISO diminazene aceturate results in increased phosphorylation of GRIN2B protein CTD PMID:31982938 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP
ISO
diminazene aceturate results in decreased expression of IL1B mRNA
diminazene aceturate results in decreased expression of IL1B protein
CTD PMID:25883526 PMID:31982938 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO
EXP
diminazene aceturate results in decreased expression of IL6 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:25883526 PMID:26862037 PMID:29977014 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO diminazene aceturate results in increased phosphorylation of MAPK1 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:26862037 PMID:31982938 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases phosphorylation EXP diminazene aceturate results in decreased phosphorylation of MAPK14 protein CTD PMID:25883526 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO diminazene aceturate results in increased phosphorylation of MAPK3 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD PMID:26862037 PMID:31982938 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor increases expression ISO diminazene aceturate results in increased expression of MAS1 protein CTD PMID:31982938 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO diminazene aceturate results in decreased expression of MCM3 mRNA CTD PMID:37681557 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO diminazene aceturate results in decreased expression of MKI67 mRNA CTD PMID:37681557 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO diminazene aceturate results in decreased expression of MYC mRNA CTD PMID:37681557 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression ISO diminazene aceturate results in decreased expression of NCF1 protein CTD PMID:29977014 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 decreases transport ISO diminazene aceturate results in decreased transport of NCF2 protein CTD PMID:29977014 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:26862037 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos1 nitric oxide synthase 1 decreases expression EXP diminazene aceturate results in decreased expression of NOS1 mRNA CTD PMID:25883526 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nox1 NADPH oxidase 1 decreases expression ISO diminazene aceturate results in decreased expression of NOX1 protein CTD PMID:29977014 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO diminazene aceturate results in decreased expression of PCNA mRNA CTD PMID:37681557 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Plk1 polo-like kinase 1 decreases expression ISO diminazene aceturate results in decreased expression of PLK1 mRNA CTD PMID:37681557 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Plk4 polo-like kinase 4 decreases expression ISO diminazene aceturate results in decreased expression of PLK4 mRNA CTD PMID:37681557 NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity
decreases expression
EXP diminazene aceturate results in decreased activity of RELA protein
diminazene aceturate results in decreased expression of RELA mRNA; diminazene aceturate results in decreased expression of RELA protein
CTD PMID:25883526 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Smad2 SMAD family member 2 decreases phosphorylation ISO diminazene aceturate results in decreased phosphorylation of SMAD2 protein CTD PMID:29977014 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 decreases phosphorylation ISO diminazene aceturate results in decreased phosphorylation of SMAD3 protein CTD PMID:29977014 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Tnf tumor necrosis factor decreases expression
decreases secretion
EXP
ISO
diminazene aceturate results in decreased expression of TNF mRNA; diminazene aceturate results in decreased expression of TNF protein
diminazene aceturate results in decreased secretion of TNF protein
CTD PMID:25883526 PMID:29977014 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      application 19735
        pharmaceutical 19543
          drug 19543
            antiinfective agent 16282
              antiparasitic agent 10061
                diminazene diaceturate 36
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            organic ion 11448
                              organic anion 6850
                                carboxylic acid anion 2500
                                  amino-acid anion 842
                                    alpha-amino-acid anion 836
                                      glycinate 36
                                        N-acylglycinate 36
                                          N-acetylglycinate 36
                                            N-acetylglycinate salt 36
                                              diminazene diaceturate 36
paths to the root