Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cathartic
go back to main search page
Accession:CHEBI:75325 term browser browse the term
Definition:Any substance that accelerates defecation. Compare with laxatives, which are substances that ease defecation (usually by softening faeces). A substance can be both a laxative and a cathartic.
Synonyms:related_synonym: cathartics
 xref: Wikipedia:Cathartic


show annotations for term's descendants           Sort by:
castor oil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 increases expression
multiple interactions		 EXP Castor Oil results in increased expression of PAFAH1B1 protein
isosorbide-5-mononitrate inhibits the reaction [Castor Oil results in increased expression of PAFAH1B1 protein]		 CTD PMID:1354728 PMID:2743081 PMID:8738301 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808 		JBrowse link
D-glucitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 multiple interactions
increases abundance		 ISO AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol]
AKR1B1 protein results in increased abundance of Sorbitol		 CTD PMID:25451566 PMID:25541468 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO [Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] affects the localization of ALOX5 protein; SB 203580 inhibits the reaction [Sorbitol results in increased activity of ALOX5 protein]; Sorbitol results in increased phosphorylation of and results in increased activity of ALOX5 protein CTD PMID:10779545 PMID:11698504 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Aqp9 aquaporin 9 multiple interactions
increases uptake		 ISO
EXP		 Sorbitol inhibits the reaction [AQP9 protein results in increased uptake of arsenite]
AQP9 protein results in increased uptake of Sorbitol		 CTD PMID:9733774 PMID:19341753 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Bola2 bolA family member 2 increases expression ISO Sorbitol results in increased expression of BOLA2 mRNA CTD PMID:35678645 NCBI chr 1:181,291,967...181,292,833
Ensembl chr 1:181,291,398...181,292,676 		JBrowse link
G Caprin1 cell cycle associated protein 1 multiple interactions ISO Sorbitol promotes the reaction [SNRNP200 protein binds to CAPRIN1 protein] CTD PMID:33939924 NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 EXP Sorbitol results in increased activity of CASP3 protein
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]		 CTD PMID:20609311 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions		 EXP Sorbitol results in increased activity of CASP8 protein
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]		 CTD PMID:20609311 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 EXP Sorbitol results in increased activity of CASP9 protein
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]		 CTD PMID:20609311 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccna1 cyclin A1 decreases expression ISO Sorbitol results in decreased expression of CCNA1 mRNA CTD PMID:35678645 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157 		JBrowse link
G Ccnf cyclin F increases expression ISO Sorbitol results in increased expression of CCNF mRNA CTD PMID:35678645 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Sorbitol results in decreased expression of CDK1 mRNA CTD PMID:35678645 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Chkb choline kinase beta decreases expression ISO Sorbitol results in decreased expression of CHKB mRNA CTD PMID:35678645 NCBI chr 7:120,500,960...120,504,359
Ensembl chr 7:120,500,984...120,504,461 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein increases phosphorylation EXP Sorbitol results in increased phosphorylation of CRK protein CTD PMID:16187300 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Ddb1 damage-specific DNA binding protein 1 increases expression ISO Sorbitol results in increased expression of DDB1 mRNA CTD PMID:35678645 NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676 		JBrowse link
G Eef1d eukaryotic translation elongation factor 1 delta increases expression ISO Sorbitol results in increased expression of EEF1D mRNA CTD PMID:35678645 NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799 		JBrowse link
G Eif3h eukaryotic translation initiation factor 3, subunit H decreases expression ISO Sorbitol results in decreased expression of EIF3H mRNA CTD PMID:35678645 NCBI chr 7:83,091,037...83,174,451
Ensembl chr 7:83,091,039...83,174,451 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:9545260 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:9545260 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Eny2 ENY2, transcription and export complex 2 subunit increases expression ISO Sorbitol results in increased expression of ENY2 mRNA CTD PMID:35678645 NCBI chr 7:75,581,215...75,605,903
Ensembl chr 7:75,581,240...75,605,897 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 increases abundance ISO FMR1 5' UTR mutant form results in increased abundance of Sorbitol CTD PMID:27385396 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP Sorbitol promotes the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:10221768 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation		 ISO JNK-IN-8 inhibits the reaction [Sorbitol results in increased phosphorylation of JUN protein] CTD PMID:24184208 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions
increases activity		 ISO Dicumarol inhibits the reaction [Sorbitol results in increased activity of MAPK10 protein] CTD PMID:10531305 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 increases phosphorylation ISO Sorbitol results in increased phosphorylation of MAPK12 protein CTD PMID:15362974 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO Sorbitol results in increased phosphorylation of MAPK14 protein CTD PMID:15362974 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 increases activity ISO Sorbitol results in increased activity of MAPK7 protein CTD PMID:11163183 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Sorbitol results in increased phosphorylation of MAPK8 protein CTD PMID:24184208 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Sorbitol results in increased phosphorylation of MAPK9 protein CTD PMID:24184208 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases activity
multiple interactions
increases phosphorylation		 ISO Sorbitol results in increased activity of MAPKAPK2 protein
SB 203580 inhibits the reaction [Sorbitol results in increased phosphorylation of MAPKAPK2 protein]		 CTD PMID:9545260 PMID:15362974 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457 		JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 increases activity ISO Sorbitol results in increased activity of MKNK1 protein CTD PMID:9545260 NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639 		JBrowse link
G Mrps16 mitochondrial ribosomal protein S16 decreases expression ISO Sorbitol results in decreased expression of MRPS16 mRNA CTD PMID:35678645 NCBI chr15:3,918,621...3,921,024
Ensembl chr15:3,918,615...3,921,656 		JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Sorbitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 increases expression ISO Sorbitol results in increased expression of PPT1 mRNA CTD PMID:35678645 NCBI chr 5:135,121,164...135,142,048
Ensembl chr 5:135,121,163...135,142,048 		JBrowse link
G Pten phosphatase and tensin homolog affects localization ISO
EXP		 Sorbitol affects the localization of PTEN protein CTD PMID:16807353 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rpl18 ribosomal protein L18 increases expression ISO Sorbitol results in increased expression of RPL18 mRNA CTD PMID:35678645 NCBI chr 1:96,188,811...96,191,452
Ensembl chr 1:96,188,112...96,191,452 		JBrowse link
G Snrnp200 small nuclear ribonucleoprotein U5 subunit 200 multiple interactions ISO Sorbitol promotes the reaction [SNRNP200 protein binds to CAPRIN1 protein] CTD PMID:33939924 NCBI chr 3:114,428,854...114,458,194
Ensembl chr 3:114,428,854...114,458,182 		JBrowse link
G Sord sorbitol dehydrogenase multiple interactions
increases metabolic processing
increases abundance		 ISO [SORD protein results in increased metabolism of Sorbitol] which results in increased abundance of Fructose; epalrestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol]; ranirestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol] CTD PMID:32367058 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133 		JBrowse link
G Tardbp TAR DNA binding protein increases ubiquitination ISO Sorbitol results in increased ubiquitination of TARDBP protein CTD PMID:31780563 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055 		JBrowse link
G Tk1 thymidine kinase 1 increases expression ISO Sorbitol results in increased expression of TK1 mRNA CTD PMID:35678645 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO Sorbitol results in decreased expression of UBE2C mRNA CTD PMID:35678645 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339 		JBrowse link
G Ubxn1 UBX domain protein 1 increases phosphorylation ISO Sorbitol results in increased phosphorylation of UBXN1 protein CTD PMID:15362974 NCBI chr 1:205,765,309...205,769,234
Ensembl chr 1:205,745,120...205,816,520 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biophysical role 14037
          cathartic 42
            D-glucitol + 41
            castor oil 1
            lactitol + 0
            magnesium sulfate heptahydrate 0
            naloxegol 0
            sennoside 0
            sennosides + 0
            sodium sulfate decahydrate 0
paths to the root