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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620331
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pafah1b1
Name: platelet-activating factor acetylhydrolase 1b, regulatory subunit 1
Acc ID: CHEBI:140618
Term: castor oil
Definition: A mixture of triglycerides obtained by pressing the seeds of the castor oil plant, Ricinus communis. The major component is triricinolein. Typical fatty acid composition on hydrolysis is 87% ricinoleic acid, 7% oleic acid, 3% linoleic acid, 2% palmitic acid, 1% stearic acid, and trace amounts of dihydroxystearic acid.
Chemical ID: MESH:D002368
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pafah1b1increases expressionEXP 6480464CTDCastor Oil results in increased expression of PAFAH1B1 protein

PMID:1354728, PMID:2743081, PMID:8738301
Pafah1b1multiple interactionsEXP 6480464CTDisosorbide-5-mononitrate inhibits the reaction [Castor Oil results in increased expression of PAFAH1B1 protein]

PMID:8738301
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.