CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: benzopteridine
Accession: CHEBI:38925
browse the term
Synonyms: related_synonym: benzopteridines
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Adora2b
adenosine A2B receptor
multiple interactions
EXP
[isoalloxazine binds to and results in decreased activity of ADORA2B protein] which results in decreased susceptibility to alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; isoalloxazine binds to and results in decreased activity of ADORA2B protein; isoalloxazine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased activity of ADORA2B protein]
CTD
PMID:16601261
NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
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Ndufa9
NADH:ubiquinone oxidoreductase subunit A9
multiple interactions
ISO
Flavin-Adenine Dinucleotide binds to and results in increased activity of NDUFA9 protein
CTD
PMID:25526675
NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018
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Rfk
riboflavin kinase
increases abundance
ISO
RFK protein results in increased abundance of Flavin-Adenine Dinucleotide
CTD
PMID:21308351
NCBI chr 1:214,799,880...214,807,440
Ensembl chr 1:214,799,825...214,807,438 Ensembl chr X:214,799,825...214,807,438
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Slc52a3
solute carrier family 52 member 3
multiple interactions
EXP
Flavin-Adenine Dinucleotide inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin]
CTD
PMID:19122205
NCBI chr 3:140,498,924...140,515,845
Ensembl chr 3:140,509,473...140,514,096
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Idh2
isocitrate dehydrogenase (NADP(+)) 2
multiple interactions increases abundance
ISO
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Flavin Mononucleotide]
CTD
PMID:27469509
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
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Rfk
riboflavin kinase
increases abundance
ISO
RFK protein results in increased abundance of Flavin Mononucleotide
CTD
PMID:21308351
NCBI chr 1:214,799,880...214,807,440
Ensembl chr 1:214,799,825...214,807,438 Ensembl chr X:214,799,825...214,807,438
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Slc52a3
solute carrier family 52 member 3
multiple interactions
EXP
Flavin Mononucleotide inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin]
CTD
PMID:19122205
NCBI chr 3:140,498,924...140,515,845
Ensembl chr 3:140,509,473...140,514,096
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Slc52a3
solute carrier family 52 member 3
multiple interactions
EXP
lumiflavin inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin]
CTD
PMID:19122205
NCBI chr 3:140,498,924...140,515,845
Ensembl chr 3:140,509,473...140,514,096
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Akt1
AKT serine/threonine kinase 1
increases phosphorylation
ISO
Riboflavin analog results in increased phosphorylation of AKT1 protein; Riboflavin results in increased phosphorylation of AKT1 protein
CTD
PMID:20688149
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Aspm
assembly factor for spindle microtubules
affects expression
ISO
Riboflavin affects the expression of ASPM
CTD
PMID:20848206
NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Riboflavin results in increased expression of BAX protein
CTD
PMID:12654180
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Riboflavin results in decreased expression of BCL2 protein
CTD
PMID:12654180
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Birc5
baculoviral IAP repeat-containing 5
affects expression
ISO
Riboflavin affects the expression of BIRC5
CTD
PMID:20848206
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Casp3
caspase 3
increases activity
ISO
Riboflavin analog results in increased activity of CASP3 protein
CTD
PMID:20688149
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
increases activity
ISO
Riboflavin analog results in increased activity of CASP8 protein
CTD
PMID:20688149
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases activity
ISO
Riboflavin analog results in increased activity of CASP9 protein
CTD
PMID:20688149
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions
EXP
Riboflavin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; Riboflavin inhibits the reaction [Lipopolysaccharides results in decreased expression of CAT protein]
CTD
PMID:26360969 PMID:34062077
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccnb1
cyclin B1
affects expression
ISO
Riboflavin affects the expression of CCNB1
CTD
PMID:20848206
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Cebpb
CCAAT/enhancer binding protein beta
increases expression
EXP
Riboflavin deficiency results in increased expression of CEBPB mRNA; Riboflavin deficiency results in increased expression of CEBPB protein
CTD
PMID:16856317
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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Crp
C-reactive protein
multiple interactions
ISO
[Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein; [Vitamin E co-treated with Ascorbic Acid co-treated with Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein
CTD
PMID:16517955
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Ctnnb1
catenin beta 1
increases expression
ISO
Riboflavin analog results in increased expression of CTNNB1 protein
CTD
PMID:20688149
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Ddit3
DNA-damage inducible transcript 3
affects expression
ISO
Riboflavin affects the expression of DDIT3
CTD
PMID:16109485
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Gpx1
glutathione peroxidase 1
multiple interactions
EXP
Riboflavin inhibits the reaction [Lipopolysaccharides results in decreased activity of GPX1 protein]
CTD
PMID:26360969
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Gsk3b
glycogen synthase kinase 3 beta
increases phosphorylation
ISO
Riboflavin analog results in increased phosphorylation of GSK3B protein; Riboflavin results in increased phosphorylation of GSK3B protein
CTD
PMID:20688149
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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Gsr
glutathione-disulfide reductase
affects expression multiple interactions
ISO EXP
Riboflavin affects the expression of GSR Riboflavin inhibits the reaction [Lipopolysaccharides results in decreased activity of GSR protein]
CTD
PMID:16109485 PMID:26360969
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Il1b
interleukin 1 beta
multiple interactions
ISO
[Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL1B protein]
CTD
PMID:17516992
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
[Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL6 protein]
CTD
PMID:17516992
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Iyd
iodotyrosine deiodinase
multiple interactions
ISO
Riboflavin inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]
CTD
PMID:33352258
NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
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Kif23
kinesin family member 23
affects expression
ISO
Riboflavin affects the expression of KIF23
CTD
PMID:20848206
NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
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Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
multiple interactions
EXP
Riboflavin inhibits the reaction [Arsenic Trioxide results in increased expression of MAP1LC3A mRNA]
CTD
PMID:34062077
NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
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Mmp9
matrix metallopeptidase 9
increases activity
ISO
Riboflavin analog results in increased activity of MMP9 protein; Riboflavin results in increased activity of MMP9 protein
CTD
PMID:20688149
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mpo
myeloperoxidase
multiple interactions
EXP
Riboflavin inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]
CTD
PMID:26360969
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mthfr
methylenetetrahydrofolate reductase
affects response to substance
ISO
MTHFR gene polymorphism affects the susceptibility to Riboflavin
CTD
PMID:17303386
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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Myc
MYC proto-oncogene, bHLH transcription factor
increases expression
ISO
Riboflavin results in increased expression of MYC protein
CTD
PMID:12654180
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Nos2
nitric oxide synthase 2
multiple interactions
ISO EXP
Lipopolysaccharides inhibits the reaction [Riboflavin results in increased expression of NOS2] Riboflavin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
CTD
PMID:21356098 PMID:26360969
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions increases cleavage
ISO
[Niacin co-treated with Ubiquinone co-treated with Riboflavin] results in increased expression of PARP1 protein Riboflavin analog results in increased cleavage of PARP1 protein
CTD
PMID:18377693 PMID:20688149
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Plagl1
PLAG1 like zinc finger 1
affects expression
ISO
Riboflavin affects the expression of PLAGL1
CTD
PMID:16109485
NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228
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Ppargc1a
PPARG coactivator 1 alpha
increases expression
ISO
Riboflavin results in increased expression of PPARGC1A mRNA
CTD
PMID:23056435
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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Runx2
RUNX family transcription factor 2
increases expression
ISO
Riboflavin analog results in increased expression of RUNX2 protein
CTD
PMID:20688149
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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Slc52a3
solute carrier family 52 member 3
multiple interactions increases transport
EXP
Acids promotes the reaction [SLC52A3 protein results in increased transport of Riboflavin]; Amiloride inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin]; Flavin Mononucleotide inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin]; Flavin-Adenine Dinucleotide inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin]; lumiflavin inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin]
CTD
PMID:19122205
NCBI chr 3:140,498,924...140,515,845
Ensembl chr 3:140,509,473...140,514,096
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Tnf
tumor necrosis factor
multiple interactions
ISO
[Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of TNF protein] Lipopolysaccharides inhibits the reaction [Riboflavin results in increased expression of TNF]
CTD
PMID:17516992 PMID:21356098
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfsf11
TNF superfamily member 11
affects expression
ISO
Riboflavin analog affects the expression of TNFSF11 protein
CTD
PMID:20688149
NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
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Tp53
tumor protein p53
increases expression
ISO
Riboflavin results in increased expression of TP53 protein
CTD
PMID:12654180
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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