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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:9,10-phenanthroquinone
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Accession:CHEBI:37454 term browser browse the term
Definition:A phenanthrene that has formula C14H8O2.
Synonyms:exact_synonym: phenanthrene-9,10-dione
 related_synonym: 9,10-Phenanthrenedione;   9,10-phenanthrenequinone;   Formula=C14H8O2;   InChI=1S/C14H8O2/c15-13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)14(13)16/h1-8H;   InChIKey=YYVYAPXYZVYDHN-UHFFFAOYSA-N;   Phenanthraquinone;   Phenanthrenequinone;   SMILES=O=C1C(=O)c2ccccc2-c2ccccc12
 alt_id: CHEBI:20817;   CHEBI:2330
 xref: Beilstein:608838;   CAS:84-11-7;   KEGG:C03243
 xref_mesh: MESH:C005399
 xref: UM-BBD_compID:c0511


show annotations for term's descendants           Sort by:
9,10-phenanthroquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 multiple interactions ISO AKR1A1 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone CTD PMID:21910479 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction
multiple interactions		 ISO AKR1B1 protein results in increased reduction of 9,10-phenanthrenequinone
AKR1B1 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone		 CTD PMID:10510318 PMID:21910479 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases metabolic processing
increases expression		 ISO AKR1B10 protein results in increased metabolism of 9,10-phenanthrenequinone
9,10-phenanthrenequinone results in increased expression of AKR1B10 mRNA		 CTD PMID:24813866 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases metabolic processing
increases reduction
multiple interactions		 ISO AKR1C1 protein results in increased metabolism of 9,10-phenanthrenequinone
AKR1C1 protein results in increased reduction of 9,10-phenanthrenequinone
AKR1C1 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone		 CTD PMID:17950253 PMID:21851338 PMID:21910479 PMID:23261716 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases metabolic processing
multiple interactions
increases reduction		 ISO AKR1C2 protein results in increased metabolism of 9,10-phenanthrenequinone
AKR1C2 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone
AKR1C2 protein results in increased reduction of 9,10-phenanthrenequinone		 CTD PMID:17950253 PMID:21851338 PMID:21910479 PMID:23261716 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases metabolic processing
multiple interactions
increases reduction
increases expression		 ISO AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone
[AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinone] which results in increased abundance of Superoxides; AKR1C3 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone; Indomethacin analog inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]; Indomethacin inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]; N-(4-chlorobenzoyl)melatonin inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]
9,10-phenanthrenequinone results in increased expression of AKR1C3 protein		 CTD PMID:17950253 PMID:19442656 PMID:21851338 PMID:21910479 PMID:23261716 More... NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 increases reduction
affects reduction
multiple interactions		 ISO AKR7A2 protein results in increased reduction of 9,10-phenanthrenequinone
9,10-phenanthrenequinone affects the reduction of AKR7A5 protein
AKR7A2 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone		 CTD PMID:10510318 PMID:12604212 PMID:21910479 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases reduction
multiple interactions		 EXP
ISO		 AKR7A3 protein results in increased reduction of 9,10-phenanthrenequinone
AKR7A3 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone		 CTD PMID:19168568 PMID:21910479 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 9,10-phenanthrenequinone results in increased expression of BAX protein CTD PMID:29108775 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO 9,10-phenanthrenequinone results in increased expression of BBC3 protein CTD PMID:29108775 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 9,10-phenanthrenequinone results in decreased expression of BCL2 protein CTD PMID:29108775 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO 9,10-phenanthrenequinone results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in increased activity of CASP3 protein]		 CTD PMID:25289770 PMID:29108775 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO 9,10-phenanthrenequinone results in increased activity of CASP9 protein
Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in increased activity of CASP9 protein]		 CTD PMID:29108775 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
increases activity		 ISO CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]
9,10-phenanthrenequinone results in increased activity of CAT protein		 CTD PMID:32493877 PMID:34391839 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbr1 carbonyl reductase 1 increases metabolic processing
multiple interactions		 ISO CBR1 protein results in increased metabolism of 9,10-phenanthrenequinone
[CBR1 protein co-treated with NADP] results in increased reduction of and affects the activity of 9,10-phenanthrenequinone; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 9,10-phenanthrenequinone]		 CTD PMID:21910479 PMID:23295225 PMID:29108775 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cbr3 carbonyl reductase 3 increases metabolic processing ISO CBR3 protein results in increased metabolism of 9,10-phenanthrenequinone CTD PMID:19061875 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO 9,10-phenanthrenequinone results in increased expression of CCL11 protein CTD PMID:15669044 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Cldn5 claudin 5 multiple interactions
decreases expression		 ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of CLDN5 protein]; 2,2'-(hydroxynitrosohydrazono)bis-ethanamine promotes the reaction [9,10-phenanthrenequinone results in decreased expression of CLDN5 protein]; 9,10-phenanthrenequinone results in decreased expression of and affects the localization of CLDN5 protein; Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of and affects the localization of CLDN5 protein]; Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of CLDN5 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of and affects the localization of CLDN5 protein] CTD PMID:34391839 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992 		JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions
increases metabolic processing		 ISO 9,10-phenanthrenequinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; [CBR2 protein co-treated with NADP] results in increased reduction of and affects the activity of 9,10-phenanthrenequinone; [DCXR protein results in increased metabolism of 9,10-phenanthrenequinone] which results in increased chemical synthesis of Hydroxyl Radical CTD PMID:21910479 PMID:28595002 NCBI chr10:106,006,404...106,008,293 JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of 9,10-phenanthrenequinone CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of 9,10-phenanthrenequinone CTD PMID:24246760 NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation		 ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of EGFR protein]; catalase-polyethylene glycol inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of EGFR protein] CTD PMID:32493877 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression		 ISO 1,10-phenanthroline inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of HMOX1 protein] CTD PMID:15629867 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il5 interleukin 5 increases expression ISO 9,10-phenanthrenequinone results in increased expression of IL5 protein CTD PMID:15669044 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO 9,10-phenanthrenequinone results in increased phosphorylation of MAPK1 protein
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of MAPK1 protein]; catalase-polyethylene glycol inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of MAPK1 protein]		 CTD PMID:32493877 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of MAPK3 protein]; catalase-polyethylene glycol inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of MAPK3 protein] CTD PMID:32493877 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases secretion
increases expression		 ISO 9,10-phenanthrenequinone results in increased secretion of MMP2 protein
9,10-phenanthrenequinone results in increased expression of MMP2 mRNA		 CTD PMID:24813866 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization ISO 9,10-phenanthrenequinone affects the localization of NFE2L2 protein CTD PMID:29108775 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO 9,10-phenanthrenequinone results in increased expression of NOS2 protein CTD PMID:34391839 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression ISO 9,10-phenanthrenequinone results in decreased expression of NOS3 protein CTD PMID:34391839 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases response to substance
increases metabolic processing
increases expression		 ISO [NQO1 protein co-treated with NADP] results in increased reduction of and affects the activity of 9,10-phenanthrenequinone; Acetylcysteine inhibits the reaction [NQO1 protein results in increased susceptibility to 9,10-phenanthrenequinone]; NQO1 protein promotes the reaction [Acetylcysteine results in decreased susceptibility to 9,10-phenanthrenequinone]
NQO1 protein results in increased metabolism of 9,10-phenanthrenequinone
9,10-phenanthrenequinone results in increased expression of NQO1 protein		 CTD PMID:21910479 PMID:22925602 PMID:29108775 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO 9,10-phenanthrenequinone results in increased expression of PMAIP1 protein CTD PMID:29108775 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO 9,10-phenanthrenequinone promotes the reaction [PRDX1 protein binds to PRDX1 protein] CTD PMID:32493877 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO [9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein; CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein] CTD PMID:32493877 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression		 ISO 1,10-phenanthroline inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of SOD1 protein] CTD PMID:15629867 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO 9,10-phenanthrenequinone binds to and results in decreased activity of TOP2A protein CTD PMID:22218491 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Tp53 tumor protein p53 affects localization ISO 9,10-phenanthrenequinone affects the localization of TP53 protein CTD PMID:29108775 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      biological role 19822
        xenobiotic 18737
          phenanthrenes 256
            9,10-phenanthroquinone 37
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    p-block element atom 19796
                      carbon group element atom 19741
                        carbon atom 19737
                          organic molecular entity 19737
                            organic molecule 19690
                              organic cyclic compound 19501
                                carbocyclic compound 18588
                                  carbopolycyclic compound 17183
                                    carbotricyclic compound 1512
                                      phenanthrenes 256
                                        9,10-phenanthroquinone 37
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