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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:theaflavin
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Accession:CHEBI:136609 term browser browse the term
Definition:A biflavonoid that is 3,4,5-trihydroxybenzocyclohepten-6-one which is substituted at positions 1 and 8 by (2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl groups. It is the main red pigment in black tea.
Synonyms:exact_synonym: 3,4,5-trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]-6H-benzocyclohepten-6-one
 related_synonym: 1,8-bis((2R,3R)-3,5,7-trihydroxy-2H-1-benzopyran-2-yl)-3,4,6-trihydroxy-5H-benzocyclohepten-5-one;   1,8-bis(3-alpha,5,7-trihydroxy-2-alpha-chromanyl)-5H-benzocyclohepten-5-one;   3,4,5-trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]-6H-benzo[7]annulen-6-one;   Formula=C29H24O12;   InChI=1S/C29H24O12/c30-11-3-17(32)15-8-21(36)28(40-23(15)5-11)10-1-13-14(7-20(35)27(39)25(13)26(38)19(34)2-10)29-22(37)9-16-18(33)4-12(31)6-24(16)41-29/h1-7,21-22,28-33,35-37,39H,8-9H2,(H,34,38)/t21-,22-,28-,29-/m1/s1;   InChIKey=IPMYMEWFZKHGAX-ZKSIBHASSA-N;   SMILES=[C@@]1(OC=2C=C(O)C=C(O)C2C[C@H]1O)([H])C3=CC(=O)C(=C4C(=C3)C([C@]5(OC=6C=C(O)C=C(O)C6C[C@H]5O)[H])=CC(O)=C4O)O;   theaflavine
 xref: CAS:4670-05-7;   Chemspider:102754;   FooDB:FDB012511;   HMDB:HMDB0005788;   KNApSAcK:C00009348
 xref_mesh: MESH:C056068
 xref: PMID:26386739;   PMID:26851019;   PMID:27237789;   PMID:27756182;   PMID:27838465;   PMID:28190756;   PMID:28381812;   PMID:28639145;   PMID:28939421;   Patent:KR20080052675;   Reaxys:25497520;   Wikipedia:Theaflavin


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theaflavin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP theaflavin inhibits the reaction [Tetrachlorodibenzodioxin binds to and affects the activity of AHR protein] CTD PMID:15914905 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Apc APC regulator of WNT signaling pathway multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of APC mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of APC protein] CTD PMID:27058323 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO theaflavin inhibits the reaction [APOE gene mutant form results in decreased activity of NOS3 protein]; theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of PTGR1 protein]; theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of SELP protein] CTD PMID:20093625 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 mRNA] CTD PMID:18656336 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA] CTD PMID:27058323 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd44 CD44 molecule multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CD44 protein] CTD PMID:27058323 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of CDH1 mRNA] CTD PMID:27058323 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [theaflavin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA] CTD PMID:23717041 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 protein] CTD PMID:27058323 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO theaflavin inhibits the reaction [EGF protein results in increased expression of FAS mRNA]; theaflavin inhibits the reaction [EGF protein results in increased expression of FAS protein] CTD PMID:12931129 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of EGFR mRNA] CTD PMID:27058323 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ERCC1 mRNA] CTD PMID:23717041 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO theaflavin inhibits the reaction [EGF protein results in increased expression of FAS mRNA]; theaflavin inhibits the reaction [EGF protein results in increased expression of FAS protein] CTD PMID:12931129 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of GADD45A mRNA] CTD PMID:23717041 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 protein] CTD PMID:27058323 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]; theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein] CTD PMID:18656336 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO theaflavin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; theaflavin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose] CTD PMID:18591783 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA] CTD PMID:23717041 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of MYC mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of MYC mRNA] CTD PMID:18656336 PMID:27058323 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myh6 myosin heavy chain 6 increases expression ISO theaflavin results in increased expression of MYHC mRNA CTD PMID:32830510 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myod1 myogenic differentiation 1 increases expression ISO theaflavin results in increased expression of MYOD1 mRNA CTD PMID:32830510 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554 		JBrowse link
G Myog myogenin increases expression ISO theaflavin results in increased expression of MYOG mRNA CTD PMID:32830510 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO theaflavin inhibits the reaction [APOE gene mutant form results in decreased activity of NOS3 protein] CTD PMID:20093625 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions ISO theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of PTGR1 protein] CTD PMID:20093625 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 mRNA] CTD PMID:23717041 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Selp selectin P multiple interactions ISO theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of SELP protein] CTD PMID:20093625 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 protein] CTD PMID:27058323 NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO theaflavin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO protein] CTD PMID:27058323 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 mRNA]; theaflavin promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 mRNA] CTD PMID:18656336 PMID:23717041 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC1 mRNA] CTD PMID:23717041 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 multiple interactions ISO [theaflavin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA] CTD PMID:23717041 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444 		JBrowse link
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  CHEBI ontology 19841
    role 19817
      chemical role 19451
        antioxidant 16140
          theaflavin 32
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  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            organic molecule 19686
                              organic cyclic compound 19498
                                organic heterocyclic compound 18876
                                  oxacycle 17888
                                    benzopyran 11957
                                      1-benzopyran 11709
                                        flavonoid oligomer 204
                                          biflavonoid 159
                                            theaflavin 32
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