The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A flavonoid oligomer that is obtained by the oxidative coupling of at least two units of aryl-substituted benzopyran rings or its substituted derivatives, resulting in the two ring systems being joined together by a single atom or bond.
agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of BDNF mRNA] agathisflavone results in increased expression of BDNF mRNA
agathisflavone promotes the reaction [Excitatory Amino Acid Agonists results in increased expression of IL10 mRNA] agathisflavone results in increased expression of IL10 mRNA
agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of IL6 mRNA] agathisflavone results in increased expression of IL6 mRNA
[agathisflavone co-treated with Excitatory Amino Acid Agonists] results in increased expression of NTF4 mRNA agathisflavone results in increased expression of NTF4 mRNA
agathisflavone results in increased expression of SLC1A3 protein agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of SLC1A3 protein]
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]
amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 protein]; CD36 protein inhibits the reaction [amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PPARG protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]
amentoflavone results in decreased expression of NOS2 protein amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]
amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PPARG protein]; CD36 protein inhibits the reaction [amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PPARG protein]]
amentoflavone results in decreased expression of PTGS2 mRNA; amentoflavone results in decreased expression of PTGS2 protein [amentoflavone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]
amentoflavone results in decreased activity of UGT1A6 protein amentoflavone inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 4-cresol]
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein] ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]
hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein]; hinokiflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of F3 protein]
hinokiflavone results in decreased expression of MMP9 protein hinokiflavone results in decreased expression of MMP9 mRNA; hinokiflavone results in decreased expression of MMP9 protein
[p-coumaric acid co-treated with procyanidin B1] results in increased expression of and results in increased phosphorylation of AKT protein; procyanidin B1 results in increased expression of and results in increased phosphorylation of AKT protein
[p-coumaric acid co-treated with procyanidin B1] results in decreased expression of and results in decreased phosphorylation of GSK3B protein; procyanidin B1 results in decreased expression of and results in decreased phosphorylation of GSK3B protein
[procyanidin B1 co-treated with p-coumaric acid] results in increased activity of GYS2 protein procyanidin B1 results in increased activity of GYS2 protein
[p-coumaric acid co-treated with procyanidin B1] results in increased expression of INSR protein procyanidin B1 results in increased expression of INSR protein
[p-coumaric acid co-treated with procyanidin B1] results in increased expression of and results in increased phosphorylation of IRS1 protein; procyanidin B1 results in increased expression of and results in increased phosphorylation of IRS1 protein [procyanidin B1 co-treated with p-coumaric acid] results in increased expression of and results in increased phosphorylation of IRS1 protein; procyanidin B1 results in increased expression of and results in increased phosphorylation of IRS1 protein
procyanidin B1 binds to [TLR4 protein binds to LY96 protein] procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased expression of LY96 mRNA]
procyanidin B1 results in decreased ubiquitination of NFE2L2 protein procyanidin B1 results in increased expression of NFE2L2 protein procyanidin B1 affects the localization of and results in increased activity of and results in increased stability of NFE2L2 protein
procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB1 mRNA]; procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB1 protein]
[procyanidin B1 co-treated with p-coumaric acid] results in decreased activity of PCK1 protein procyanidin B1 results in decreased activity of PCK1 protein
[p-coumaric acid co-treated with procyanidin B1] results in increased expression of and results in increased phosphorylation of PIK3R1 protein; procyanidin B1 results in increased expression of and results in increased phosphorylation of PIK3R1 protein
procyanidin B1 binds to PTPN1 protein procyanidin B1 results in decreased activity of PTPN1 protein procyanidin B1 results in decreased expression of PTPN1 mRNA; procyanidin B1 results in decreased expression of PTPN1 protein
[procyanidin B1 co-treated with p-coumaric acid] results in decreased activity of PYGL protein procyanidin B1 results in decreased activity of PYGL protein
[procyanidin B1 co-treated with p-coumaric acid] results in increased expression of SLC2A4 protein procyanidin B1 results in increased expression of SLC2A4 protein
procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; procyanidin B1 inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
[Diquat co-treated with procyanidin B2] results in increased expression of ATG12 mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of ATG12 mRNA
procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of BAX protein] procyanidin B2 affects the reaction [Diquat affects the expression of BAX mRNA]; procyanidin B2 affects the reaction [Hydrogen Peroxide affects the expression of BAX mRNA] procyanidin B2 results in decreased expression of BAX protein
procyanidin B2 affects the reaction [Diquat affects the expression of BCL2 mRNA]; procyanidin B2 affects the reaction [Hydrogen Peroxide affects the expression of BCL2 mRNA]
procyanidin B2 inhibits the reaction [Diquat results in increased expression of BCL2L11 mRNA]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of BCL2L11 mRNA]
[Diquat co-treated with procyanidin B2] results in increased expression of BECN1 mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of BECN1 mRNA
procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of CASP3 protein modified form] 3-methyladenine inhibits the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; FOXO1 protein affects the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; procyanidin B2 inhibits the reaction [Diquat results in increased expression of CASP3 mRNA]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA] procyanidin B2 results in decreased expression of CASP3 protein modified form
procyanidin B2 results in decreased activity of CASP9 protein procyanidin B2 inhibits the reaction [MFGE8 protein results in increased activity of CASP9 protein]
procyanidin B2 inhibits the reaction [Diquat results in decreased activity of CAT protein] procyanidin B2 inhibits the reaction [Carrageenan results in decreased activity of CAT protein]
FOXO1 protein affects the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; procyanidin B2 inhibits the reaction [Diquat results in increased expression of FOXO1 mRNA]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of and affects the localization of FOXO1 protein]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO1 mRNA]
procyanidin B2 results in increased expression of GSK3B protein modified form procyanidin B2 inhibits the reaction [MFGE8 protein results in decreased expression of GSK3B protein modified form]
procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL18 mRNA]; procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL18 protein]
procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL1B mRNA]; procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL1B protein]
[Diquat co-treated with procyanidin B2] results in increased expression of MAP1LC3B mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of MAP1LC3B mRNA
procyanidin B2 inhibits the reaction [MFGE8 protein affects the localization of CYCS protein]; procyanidin B2 inhibits the reaction [MFGE8 protein results in decreased expression of GSK3B protein modified form]; procyanidin B2 inhibits the reaction [MFGE8 protein results in increased activity of CASP9 protein]; procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of BAX protein]; procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of CASP3 protein modified form] procyanidin B2 affects the susceptibility to MFGE8 protein
procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS2 mRNA]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS2 protein]
[Diquat co-treated with procyanidin B2] results in increased expression of PIK3C3 mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of PIK3C3 mRNA
procyanidin B2 binds to PTPN1 protein procyanidin B2 results in decreased expression of PTPN1 mRNA; procyanidin B2 results in decreased expression of PTPN1 protein procyanidin B2 results in decreased activity of PTPN1 protein
procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS1 mRNA]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS1 protein]
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
[Eicosapentaenoic Acid co-treated with procyanidin B3] inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA]; procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA]
[Lipopolysaccharides co-treated with procyanidin B3] results in decreased phosphorylation of MAPK8 protein; Eicosapentaenoic Acid promotes the reaction [[Lipopolysaccharides co-treated with procyanidin B3] results in decreased phosphorylation of MAPK8 protein]; procyanidin B3 promotes the reaction [[Lipopolysaccharides co-treated with Eicosapentaenoic Acid] results in decreased phosphorylation of MAPK8 protein]
procyanidin B3 inhibits the reaction [[Lipopolysaccharides co-treated with Eicosapentaenoic Acid] results in increased phosphorylation of RELA protein]
sciadopitysin results in decreased activity of ABCB1 protein sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
sciadopitysin results in increased expression of BGLAP protein sciadopitysin inhibits the reaction [Antimycin A results in increased expression of BGLAP protein]
theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of APC mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of APC protein]
theaflavin inhibits the reaction [APOE gene mutant form results in decreased activity of NOS3 protein]; theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of PTGR1 protein]; theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of SELP protein]
[theaflavin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA]
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 protein]
theaflavin inhibits the reaction [EGF protein results in increased expression of FAS mRNA]; theaflavin inhibits the reaction [EGF protein results in increased expression of FAS protein]
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of EGFR mRNA] [theaflavin co-treated with theaflavine gallate co-treated with theaflavin-3,3'-digallate] inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased phosphorylation of EGFR protein]; [theaflavin co-treated with theaflavine gallate co-treated with theaflavin-3,3'-digallate] inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EGFR mRNA]
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ERCC1 mRNA]
theaflavin inhibits the reaction [EGF protein results in increased expression of FAS mRNA]; theaflavin inhibits the reaction [EGF protein results in increased expression of FAS protein]
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of GADD45A mRNA]
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 protein]
theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]; theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]
theaflavin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; theaflavin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]
[theaflavin co-treated with theaflavine gallate co-treated with theaflavin-3,3'-digallate] inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased phosphorylation of MUC5AC protein]; [theaflavin co-treated with theaflavine gallate co-treated with theaflavin-3,3'-digallate] inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA]
theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of MYC mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of MYC mRNA]
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 mRNA]
theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 protein]
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO protein]
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 mRNA]; theaflavin promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 mRNA]
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC1 mRNA]
[theaflavin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]
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