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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flavonoid oligomer
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Accession:CHEBI:72720 term browser browse the term
Definition:A phenylpropanoid obtained by the coupling of two or more units of aryl-substituted benzopyran units and their substituted derivatives.
Synonyms:related_synonym: flavonoid oligomers

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agathisflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 multiple interactions EXP agathisflavone promotes the reaction [Excitatory Amino Acid Agonists results in increased expression of ARG1 mRNA] CTD PMID:29425760 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression		 EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of BDNF mRNA]
agathisflavone results in increased expression of BDNF mRNA		 CTD PMID:29425760 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of CASP3 protein modified form] CTD PMID:29425760 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cdnf cerebral dopamine neurotrophic factor increases expression EXP agathisflavone results in increased expression of CDNF mRNA CTD PMID:29425760 NCBI chr17:78,721,230...78,735,324
Ensembl chr17:78,719,111...78,735,324 		JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP agathisflavone promotes the reaction [Excitatory Amino Acid Agonists results in increased expression of GDNF mRNA] CTD PMID:29425760 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238 		JBrowse link
G Glul glutamate-ammonia ligase multiple interactions EXP [agathisflavone co-treated with Excitatory Amino Acid Agonists] results in increased expression of GLUL protein CTD PMID:29425760 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression		 EXP agathisflavone promotes the reaction [Excitatory Amino Acid Agonists results in increased expression of IL10 mRNA]
agathisflavone results in increased expression of IL10 mRNA		 CTD PMID:29425760 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of IL1B mRNA] CTD PMID:29425760 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of IL6 mRNA]
agathisflavone results in increased expression of IL6 mRNA		 CTD PMID:29425760 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of ITGAM protein] CTD PMID:29425760 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960 		JBrowse link
G Mrc1 mannose receptor, C type 1 increases expression EXP agathisflavone results in increased expression of MRC1 protein CTD PMID:29425760 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP [agathisflavone co-treated with Excitatory Amino Acid Agonists] results in increased expression of NGF mRNA CTD PMID:29425760 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Ntf4 neurotrophin 4 multiple interactions
increases expression		 EXP [agathisflavone co-treated with Excitatory Amino Acid Agonists] results in increased expression of NTF4 mRNA
agathisflavone results in increased expression of NTF4 mRNA		 CTD PMID:29425760 NCBI chr 1:101,405,314...101,408,145
Ensembl chr 1:101,405,314...101,408,145 		JBrowse link
G Slc1a3 solute carrier family 1 member 3 increases expression
multiple interactions		 EXP agathisflavone results in increased expression of SLC1A3 protein
agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of SLC1A3 protein]		 CTD PMID:29425760 NCBI chr 2:57,860,881...57,935,363
Ensembl chr 2:57,860,834...57,935,363 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of TNF mRNA] CTD PMID:29425760 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
amentoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AIF1 protein] CTD PMID:28185818 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein] CTD PMID:28185818 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]		 CTD PMID:28185818 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form] CTD PMID:28185818 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CDKN1A protein] CTD PMID:28185818 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO amentoflavone results in decreased activity of CYP1B1 protein CTD PMID:16271822 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Dct dopachrome tautomerase decreases expression ISO amentoflavone analog results in decreased expression of DCT mRNA; amentoflavone analog results in decreased expression of DCT protein CTD PMID:17473463 NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein] CTD PMID:28185818 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein] CTD PMID:28185818 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein] CTD PMID:28185818 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein] CTD PMID:28185818 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions		 ISO amentoflavone results in decreased expression of NOS2 protein
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]		 CTD PMID:12144868 PMID:28185818 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO amentoflavone binds to PTGDS protein CTD PMID:26456343 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions		 ISO amentoflavone results in decreased expression of PTGS2 mRNA; amentoflavone results in decreased expression of PTGS2 protein
[amentoflavone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone		 CTD PMID:12144868 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:28185818 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Tyr tyrosinase decreases activity ISO amentoflavone analog results in decreased activity of TYR protein CTD PMID:17473463 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity ISO amentoflavone results in decreased activity of UGT1A1 protein CTD PMID:29470958 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO amentoflavone results in decreased activity of UGT1A3 protein CTD PMID:29470958 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 decreases activity ISO amentoflavone results in decreased activity of UGT1A4 protein CTD PMID:29470958 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases activity
multiple interactions		 ISO amentoflavone results in decreased activity of UGT1A6 protein
amentoflavone inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 4-cresol]		 CTD PMID:29470958 PMID:32421801 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 decreases activity ISO amentoflavone results in decreased activity of UGT1A8 protein CTD PMID:29470958 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 decreases activity ISO amentoflavone results in decreased activity of UGT1A9 protein CTD PMID:29470958 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 decreases activity ISO amentoflavone results in decreased activity of UGT2B17 protein CTD PMID:29470958 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444 		JBrowse link
cupressuflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hexb hexosaminidase subunit beta multiple interactions ISO cupressuflavone inhibits the reaction [Oxazolone results in increased secretion of HEXB protein] CTD PMID:29258854 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO cupressuflavone inhibits the reaction [Oxazolone results in increased secretion of IL4 protein] CTD PMID:29258854 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
ginkgetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]		 CTD PMID:25968939 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]		 CTD PMID:25968939 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein] CTD PMID:25968939 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Ftl1 ferritin light chain 1 decreases expression ISO ginkgetin results in decreased expression of FTL1 protein
ginkgetin results in decreased expression of FTL protein		 CTD PMID:25968939 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829 		JBrowse link
G Tfrc transferrin receptor increases expression ISO ginkgetin results in increased expression of TFRC protein CTD PMID:25968939 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:25968939 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
hinokiflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO hinokiflavone results in increased expression of BAX protein CTD PMID:30575109 PMID:32252563 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO hinokiflavone results in decreased expression of BCL2 protein CTD PMID:30575109 PMID:32252563 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage		 ISO hinokiflavone results in increased expression of CASP3 protein
hinokiflavone results in increased cleavage of CASP3 protein		 CTD PMID:30575109 PMID:32252563 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein]; hinokiflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of F3 protein] CTD PMID:8882428 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein] CTD PMID:8882428 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:29673161 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:29673161 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:29673161 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO hinokiflavone results in decreased expression of MMP2 mRNA; hinokiflavone results in decreased expression of MMP2 protein CTD PMID:29635122 PMID:30575109 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO hinokiflavone results in decreased expression of MMP9 protein
hinokiflavone results in decreased expression of MMP9 mRNA; hinokiflavone results in decreased expression of MMP9 protein		 CTD PMID:29635122 PMID:30575109 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:29673161 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Prpf40a pre-mRNA processing factor 40 homolog A increases sumoylation ISO hinokiflavone results in increased sumoylation of PRPF40A protein CTD PMID:28884683 NCBI chr 3:38,680,583...38,741,570
Ensembl chr 3:38,682,146...38,741,113 		JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO hinokiflavone binds to PTGDS protein CTD PMID:26456343 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:29673161 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:29673161 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Senp1 SUMO specific peptidase 1 decreases activity ISO hinokiflavone results in decreased activity of SENP1 protein CTD PMID:28884683 NCBI chr 7:139,626,444...139,684,587
Ensembl chr 7:139,630,515...139,675,245
Ensembl chr 7:139,630,515...139,675,245 		JBrowse link
G Sf3a2 splicing factor 3a, subunit 2 increases sumoylation ISO hinokiflavone results in increased sumoylation of SF3A2 protein CTD PMID:28884683 NCBI chr 7:11,777,826...11,784,373
Ensembl chr 7:11,777,826...11,783,849 		JBrowse link
G Sf3b1 splicing factor 3b, subunit 1 increases sumoylation ISO hinokiflavone results in increased sumoylation of SF3B1 protein CTD PMID:28884683 NCBI chr 9:61,594,620...61,634,510
Ensembl chr 9:61,594,620...61,634,510 		JBrowse link
G Sf3b2 splicing factor 3b, subunit 2 increases sumoylation ISO hinokiflavone results in increased sumoylation of SF3B2 protein CTD PMID:28884683 NCBI chr 1:220,645,685...220,665,611
Ensembl chr 1:220,645,672...220,665,603 		JBrowse link
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide increases sumoylation ISO hinokiflavone results in increased sumoylation of SNRPD2 protein CTD PMID:28884683 NCBI chr 1:80,057,140...80,059,990
Ensembl chr 1:80,056,755...80,059,996 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 increases localization ISO hinokiflavone results in increased localization of SUMO1 protein CTD PMID:28884683 NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614 		JBrowse link
G Sumo2 small ubiquitin-like modifier 2 increases localization ISO hinokiflavone results in increased localization of SUMO2 protein CTD PMID:28884683 NCBI chr10:104,085,401...104,097,983
Ensembl chr10:104,086,002...104,097,812 		JBrowse link
G Sumo3 small ubiquitin-like modifier 3 increases localization ISO hinokiflavone results in increased localization of SUMO3 protein CTD PMID:28884683 NCBI chr20:11,726,488...11,737,050
Ensembl chr20:11,726,497...11,737,050 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO hinokiflavone results in increased expression of TIMP2 mRNA; hinokiflavone results in increased expression of TIMP2 protein CTD PMID:30575109 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:29673161 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G U2surp U2 snRNP-associated SURP domain containing increases sumoylation ISO hinokiflavone results in increased sumoylation of U2SURP protein CTD PMID:28884683 NCBI chr 8:103,242,095...103,299,082
Ensembl chr 8:103,246,558...103,298,927 		JBrowse link
proanthocyanidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity EXP Proanthocyanidins results in decreased activity of ACE protein CTD PMID:16390204 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Proanthocyanidins inhibits the reaction [Cadmium results in decreased activity of ACHE protein] CTD PMID:25463594 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of ACTA2 protein] CTD PMID:33484087 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of APP protein modified form] CTD PMID:25088297 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO Proanthocyanidins inhibits the reaction [quinocetone metabolite results in decreased expression of ATF1 mRNA] CTD PMID:26802905 NCBI chr 7:141,882,261...141,924,790
Ensembl chr 7:141,882,251...141,924,788 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP
ISO		 Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of BAX protein]
Proanthocyanidins results in increased expression of BAX mRNA; Proanthocyanidins results in increased expression of BAX protein		 CTD PMID:18611398 PMID:29654773 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
Proanthocyanidins results in decreased expression of BCL2 mRNA; Proanthocyanidins results in decreased expression of BCL2 protein		 CTD PMID:18611398 PMID:29654773 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l11 BCL2 like 11 decreases expression ISO Proanthocyanidins results in decreased expression of BCL2L11 mRNA CTD PMID:29205955 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Casp3 caspase 3 decreases expression
increases cleavage
increases expression		 ISO Proanthocyanidins results in decreased expression of CASP3 mRNA
Proanthocyanidins results in increased cleavage of CASP3 protein
Proanthocyanidins results in increased expression of CASP3 mRNA		 CTD PMID:29205955 PMID:29654773 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase increases activity
multiple interactions		 ISO
EXP		 Proanthocyanidins results in increased activity of CAT protein
Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]		 CTD PMID:29205955 PMID:33484087 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression ISO proanthocyanidin results in decreased expression of CCR2 mRNA CTD PMID:12462994
G Ccr3 C-C motif chemokine receptor 3 decreases expression ISO proanthocyanidin results in decreased expression of CCR3 mRNA; proanthocyanidin results in decreased expression of CCR3 protein CTD PMID:12462994 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 decreases expression ISO proanthocyanidin results in decreased expression of CCR5 mRNA CTD PMID:12462994 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
increases expression		 EXP Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased expression of CDK4 protein]
Proanthocyanidins results in increased expression of CDK4 protein		 CTD PMID:33484087 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of CDKN2A protein] CTD PMID:33484087 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Ckb creatine kinase B multiple interactions EXP Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Proanthocyanidins results in decreased expression of [CKM protein binds to CKB protein] CTD PMID:33484087 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Proanthocyanidins results in decreased expression of [CKM protein binds to CKB protein] CTD PMID:33484087 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Proanthocyanidins inhibits the reaction [quinocetone metabolite affects the expression of CREB1 mRNA] CTD PMID:26802905 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions ISO Proanthocyanidins affects the reaction [cyadox metabolite affects the expression of CYP11B1 protein]; Proanthocyanidins affects the reaction [Mequindox metabolite results in decreased expression of CYP11B1 protein]; Proanthocyanidins affects the reaction [quinocetone metabolite affects the expression of CYP11B1 mRNA]; Proanthocyanidins affects the reaction [quinocetone metabolite affects the expression of CYP11B1 protein]; Proanthocyanidins inhibits the reaction [cyadox metabolite results in decreased expression of CYP11B1 mRNA]; Proanthocyanidins inhibits the reaction [Mequindox metabolite results in decreased expression of CYP11B1 mRNA] CTD PMID:26802905 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions ISO Proanthocyanidins affects the reaction [cyadox metabolite affects the expression of CYP11B2 mRNA]; Proanthocyanidins affects the reaction [cyadox metabolite affects the expression of CYP11B2 protein]; Proanthocyanidins affects the reaction [Mequindox metabolite results in decreased expression of CYP11B2 protein]; Proanthocyanidins affects the reaction [quinocetone metabolite affects the expression of CYP11B2 protein]; Proanthocyanidins inhibits the reaction [Mequindox metabolite results in decreased expression of CYP11B2 mRNA]; Proanthocyanidins inhibits the reaction [quinocetone metabolite results in decreased expression of CYP11B2 mRNA] CTD PMID:26802905 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25088297 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of EIF2S1 protein] CTD PMID:25088297 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of ERN1 protein] CTD PMID:25088297 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase affects binding
multiple interactions		 EXP Proanthocyanidins binds to HMGCR protein
Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of HMGCR protein]		 CTD PMID:30273964 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions EXP Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HNF4A mRNA] CTD PMID:30273964 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of HSPA5 protein] CTD PMID:25088297 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of IL1B protein] CTD PMID:25088297 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions		 EXP Proanthocyanidins results in decreased expression of IL2 protein
Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of IL2 protein]		 CTD PMID:33484087 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of IL6 protein] CTD PMID:33484087 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LCAT protein] CTD PMID:30273964 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of LDLR mRNA] CTD PMID:30273964 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LPL protein] CTD PMID:30273964 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of MAPK8 protein] CTD PMID:25088297 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of MAPK9 protein] CTD PMID:25088297 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of MAPT protein] CTD PMID:25088297 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO Proanthocyanidins inhibits the reaction [quinocetone metabolite affects the expression of NR4A1 mRNA] CTD PMID:26802905 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO Proanthocyanidins inhibits the reaction [quinocetone metabolite results in decreased expression of NR4A2 mRNA] CTD PMID:26802905 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions ISO Proanthocyanidins inhibits the reaction [quinocetone metabolite affects the expression of NR5A1 mRNA] CTD PMID:26802905 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO Proanthocyanidins inhibits the reaction [3-chloroperbenzoic acid results in increased activity of ODC1 protein] CTD PMID:7653998 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions EXP Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein] CTD PMID:30273964 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of PTGS2 protein] CTD PMID:25088297 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases expression		 EXP Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased expression of RB1 protein]
Proanthocyanidins results in increased expression of RB1 protein		 CTD PMID:33484087 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Proanthocyanidins inhibits the reaction [lead acetate affects the localization of RELA protein] CTD PMID:25088297 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Snca synuclein alpha decreases expression ISO Proanthocyanidins results in decreased expression of SNCA protein CTD PMID:29976995 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein] CTD PMID:33484087 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of TNF protein] CTD PMID:25088297 PMID:33484087 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnni1 troponin I1, slow skeletal type multiple interactions EXP Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of TNNI1 protein] CTD PMID:33484087 NCBI chr13:52,624,856...52,637,297
Ensembl chr13:52,624,878...52,637,297 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Proanthocyanidins results in increased expression of TP53 mRNA; Proanthocyanidins results in increased expression of TP53 protein CTD PMID:29654773 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
procyanidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk1 cyclin-dependent kinase 1 decreases phosphorylation ISO procyanidin results in decreased phosphorylation of CDK1 protein CTD PMID:15827326 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation ISO procyanidin results in decreased phosphorylation of FOXO1 protein CTD PMID:15827326 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO procyanidin results in decreased phosphorylation of and results in decreased expression of RB1 protein CTD PMID:15827326 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Tp53 tumor protein p53 decreases phosphorylation ISO procyanidin results in decreased phosphorylation of TP53 protein CTD PMID:15827326 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
procyanidin B2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of AGER protein] CTD PMID:25199697 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO procyanidin B2 results in increased phosphorylation of AKT1 protein CTD PMID:21945981 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alb albumin multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of ALB protein] CTD PMID:25199697 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Atg12 autophagy related 12 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of ATG12 mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of ATG12 mRNA CTD PMID:27057282 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression		 ISO procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of BAX protein]
procyanidin B2 affects the reaction [Diquat affects the expression of BAX mRNA]; procyanidin B2 affects the reaction [Hydrogen Peroxide affects the expression of BAX mRNA]
procyanidin B2 results in decreased expression of BAX protein		 CTD PMID:21505870 PMID:27057282 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO procyanidin B2 affects the reaction [Diquat affects the expression of BCL2 mRNA]; procyanidin B2 affects the reaction [Hydrogen Peroxide affects the expression of BCL2 mRNA] CTD PMID:27057282 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions ISO procyanidin B2 inhibits the reaction [Diquat results in increased expression of BCL2L11 mRNA]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of BCL2L11 mRNA] CTD PMID:27057282 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of BECN1 mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of BECN1 mRNA CTD PMID:27057282 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO procyanidin B2 results in increased expression of BRCA1 mRNA CTD PMID:25839702 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased expression of CASP1 protein] CTD PMID:30025709 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression		 ISO procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of CASP3 protein modified form]
3-methyladenine inhibits the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; FOXO1 protein affects the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; procyanidin B2 inhibits the reaction [Diquat results in increased expression of CASP3 mRNA]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]
procyanidin B2 results in decreased expression of CASP3 protein modified form		 CTD PMID:21505870 PMID:27057282 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 decreases activity
multiple interactions		 ISO procyanidin B2 results in decreased activity of CASP9 protein
procyanidin B2 inhibits the reaction [MFGE8 protein results in increased activity of CASP9 protein]		 CTD PMID:21505870 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 procyanidin B2 inhibits the reaction [Diquat results in decreased activity of CAT protein]
procyanidin B2 inhibits the reaction [Carrageenan results in decreased activity of CAT protein]		 CTD PMID:27057282 PMID:28844677 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA] CTD PMID:25199697 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO procyanidin B2 results in increased expression of CDH1 mRNA CTD PMID:25839702 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions		 ISO procyanidin B2 affects the localization of CYCS protein
procyanidin B2 inhibits the reaction [MFGE8 protein affects the localization of CYCS protein]		 CTD PMID:21505870 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression ISO procyanidin B2 results in increased expression of DNMT1 mRNA CTD PMID:25839702 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha increases expression ISO procyanidin B2 results in increased expression of DNMT3A mRNA CTD PMID:25839702 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta increases expression ISO procyanidin B2 results in increased expression of DNMT3B mRNA CTD PMID:25839702 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO FOXO1 protein affects the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; procyanidin B2 inhibits the reaction [Diquat results in increased expression of FOXO1 mRNA]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of and affects the localization of FOXO1 protein]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO1 mRNA] CTD PMID:27057282 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression
multiple interactions		 ISO procyanidin B2 results in increased expression of GSK3B protein modified form
procyanidin B2 inhibits the reaction [MFGE8 protein results in decreased expression of GSK3B protein modified form]		 CTD PMID:21505870 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in decreased expression of HMOX1 protein] CTD PMID:28844677 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in increased secretion of IL10 protein] CTD PMID:28844677 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL18 mRNA]; procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL18 protein] CTD PMID:30025709 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL1B mRNA]; procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL1B protein] CTD PMID:30025709 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in increased secretion of IL6 protein] CTD PMID:28844677 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Klk7 kallikrein-related peptidase 7 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in increased expression of KLK3 protein] CTD PMID:28844677 NCBI chr 1:99,749,991...99,754,723
Ensembl chr 1:99,749,936...99,754,435 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of MAP1LC3B mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of MAP1LC3B mRNA CTD PMID:27057282 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO procyanidin B2 results in increased phosphorylation of MAPK1 protein CTD PMID:21945981 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO procyanidin B2 results in increased phosphorylation of MAPK3 protein CTD PMID:21945981 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mfge8 milk fat globule EGF and factor V/VIII domain containing multiple interactions
affects response to substance		 ISO procyanidin B2 inhibits the reaction [MFGE8 protein affects the localization of CYCS protein]; procyanidin B2 inhibits the reaction [MFGE8 protein results in decreased expression of GSK3B protein modified form]; procyanidin B2 inhibits the reaction [MFGE8 protein results in increased activity of CASP9 protein]; procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of BAX protein]; procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of CASP3 protein modified form]
procyanidin B2 affects the susceptibility to MFGE8 protein		 CTD PMID:21505870 NCBI chr 1:140,845,478...140,860,882
Ensembl chr 1:140,845,465...140,860,894 		JBrowse link
G Mir122 microRNA 122 decreases expression EXP
ISO		 procyanidin B2 results in decreased expression of MIR122 mRNA CTD PMID:24165878 NCBI chr18:60,755,285...60,755,369 JBrowse link
G Mpo myeloperoxidase multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased activity of MPO protein] CTD PMID:30025709 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan affects the localization of NFE2L2 protein] CTD PMID:28844677 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased expression of NLRP3 protein] CTD PMID:30025709 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS2 mRNA]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS2 protein] CTD PMID:25199697 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in decreased expression of NQO1 protein] CTD PMID:28844677 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of PIK3C3 mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of PIK3C3 mRNA CTD PMID:27057282 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of PRKCA protein] CTD PMID:25199697 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased expression of PYCARD protein] CTD PMID:30025709 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210 		JBrowse link
G Serpinb5 serpin family B member 5 increases expression ISO procyanidin B2 results in increased expression of SERPINB5 mRNA CTD PMID:25839702 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in increased expression of TNF protein] CTD PMID:28844677 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO procyanidin B2 results in decreased activity of TOP2A protein CTD PMID:16536579 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA] CTD PMID:25199697 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:25199697 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
procyanidin B3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of AGER mRNA CTD PMID:22169119 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079 		JBrowse link
G Cat catalase multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of CAT mRNA CTD PMID:22169119 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:22169119 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA] CTD PMID:22169119 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL7 mRNA] CTD PMID:22169119 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979 		JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 mRNA] CTD PMID:22169119 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 mRNA] CTD PMID:22169119 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of FAS mRNA] CTD PMID:22169119 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of GCLM mRNA CTD PMID:22169119 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3] promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA] CTD PMID:22169119 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA] CTD PMID:22169119 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] CTD PMID:22169119 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:22169119 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions ISO procyanidin B3 promotes the reaction [Lipopolysaccharides results in increased expression of IL2RA mRNA] CTD PMID:22169119 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:22169119 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3] inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA]; procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA] CTD PMID:22169119 NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Lipopolysaccharides co-treated with procyanidin B3] results in decreased phosphorylation of MAPK8 protein; Eicosapentaenoic Acid promotes the reaction [[Lipopolysaccharides co-treated with procyanidin B3] results in decreased phosphorylation of MAPK8 protein]; procyanidin B3 promotes the reaction [[Lipopolysaccharides co-treated with Eicosapentaenoic Acid] results in decreased phosphorylation of MAPK8 protein] CTD PMID:22169119 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3] promotes the reaction [Lipopolysaccharides results in increased expression of MSR1 mRNA] CTD PMID:22169119 NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3] inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB2 mRNA] CTD PMID:22169119 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO procyanidin B3 inhibits the reaction [[Lipopolysaccharides co-treated with Eicosapentaenoic Acid] results in increased phosphorylation of RELA protein] CTD PMID:22169119 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA] CTD PMID:22169119 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B mRNA] CTD PMID:22169119 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299 		JBrowse link
sciadopitysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions		 ISO sciadopitysin results in decreased activity of ABCB1 protein
sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]		 CTD PMID:30790579 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
multiple interactions		 ISO sciadopitysin results in increased expression of BGLAP protein
sciadopitysin inhibits the reaction [Antimycin A results in increased expression of BGLAP protein]		 CTD PMID:23624148 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO sciadopitysin inhibits the reaction [Antimycin A results in increased expression of TNF protein] CTD PMID:23624148 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
theaflavin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of APC mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of APC protein] CTD PMID:27058323 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO theaflavin inhibits the reaction [APOE gene mutant form results in decreased activity of NOS3 protein]; theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of PTGR1 protein]; theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of SELP protein] CTD PMID:20093625 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 mRNA] CTD PMID:18656336 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA] CTD PMID:27058323 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CD44 protein] CTD PMID:27058323 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of CDH1 mRNA] CTD PMID:27058323 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [theaflavin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA] CTD PMID:23717041 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 protein] CTD PMID:27058323 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of EGFR mRNA] CTD PMID:27058323 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ERCC1 mRNA] CTD PMID:23717041 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of GADD45A mRNA] CTD PMID:23717041 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 protein] CTD PMID:27058323 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]; theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein] CTD PMID:18656336 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA] CTD PMID:23717041 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of MYC mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of MYC mRNA] CTD PMID:18656336 PMID:27058323 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO theaflavin inhibits the reaction [APOE gene mutant form results in decreased activity of NOS3 protein] CTD PMID:20093625 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions ISO theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of PTGR1 protein] CTD PMID:20093625 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 mRNA] CTD PMID:23717041 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Selp selectin P multiple interactions ISO theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of SELP protein] CTD PMID:20093625 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 protein] CTD PMID:27058323 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO theaflavin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487 		JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO protein] CTD PMID:27058323 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 mRNA]; theaflavin promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 mRNA] CTD PMID:18656336 PMID:23717041 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC1 mRNA] CTD PMID:23717041 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 multiple interactions ISO [theaflavin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA] CTD PMID:23717041 NCBI chr 6:136,366,917...136,380,751
Ensembl chr 6:136,371,555...136,379,348 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19775
    chemical entity 19775
      atom 19774
        nonmetal atom 19655
          oxygen atom 19368
            oxygen molecular entity 19368
              flavonoids 10819
                flavonoid oligomer 165
                  (2S,2''S,3S,3''R,4S)-3,4',5,7-Tetrahydroxyflavan(2->7,4->8)-3,4',5,7-tetrahydroxyflavan 0
                  (\{6-[2-(3,4-dihydroxyphenyl)-4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-8-yl]-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-6-yl]-3,4,5-trihydroxyoxan-2-yl\}methoxy)sulfonic acid 0
                  2-(3,4-dihydroxyphenyl)-4-[3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl]-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,4-dihydro-2H-1-benzopyran-3,5,7-triol 0
                  3,3'-Digalloylprocyanidin B2 0
                  3-O-alpha-L-Arabinopyranosylproanthocyanidin A5' 0
                  5,13-bis(3,4-dihydroxyphenyl)-18-[3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-4,12,14-trioxapentacyclo[11.7.1.0?,??.0?,?.0??,??]henicosa-2(11),3(8),9,15(20),16,18-hexaene-6,9,17,19,21-pentol 0
                  5-(3,4-dihydroxyphenyl)-18-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-4-yl]-13-(4-hydroxy-3-methoxyphenyl)-4,12,14-trioxapentacyclo[11.7.1.0?,??.0?,?.0??,??]henicosa-2(11),3(8),9,15(20),16,18-hexaene-6,9,17,19,21-pentol 0
                  Catechin-(4alpha->8)-gallocatechin-(4alpha->8)-catechin 0
                  Dihydromorelloflavone 0
                  Epicatechin 3-O-gallate-(4beta->6)-epigallocatechin 3-O-gallate 0
                  Epicatechin-(2beta->5,4beta->6)-ent-epicatechin 0
                  Epicatechin-(2beta->7,4beta->6)-catechin 0
                  Epicatechin-(4beta->6)-epicatechin-(2beta->7,4beta->8)-epicatechin 0
                  Epigallocatechin-(4beta->8)-catechin 0
                  Gallocatechin-(4alpha->8)-catechin-(4alpha->8)-catechin 0
                  Gallocatechin-(4alpha->8)-gallocatechin-(4alpha->8)-gallocatechin 0
                  Proanthocyanidin A1 0
                  biflavonoid + 128
                  ent-Epiafzelechin(2a->7,4a->8)epiafzelechin 3-(4-hydroxybenzoic acid) 0
                  ent-Epicatechin(4alpha->8)catechin 0
                  ent-Epicatechin-(4alpha->6)-ent-epicatechin 0
                  proanthocyanidin + 99
Path 2
Term Annotations click to browse term
  CHEBI ontology 19775
    subatomic particle 19774
      composite particle 19774
        hadron 19774
          baryon 19774
            nucleon 19774
              atomic nucleus 19774
                atom 19774
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19584
                        carbon atom 19574
                          organic molecular entity 19574
                            organic molecule 19508
                              organic cyclic compound 19338
                                organic heterocyclic compound 18567
                                  oxacycle 17557
                                    benzopyran 10281
                                      1-benzopyran 10003
                                        flavonoid oligomer 165
                                          (2S,2''S,3S,3''R,4S)-3,4',5,7-Tetrahydroxyflavan(2->7,4->8)-3,4',5,7-tetrahydroxyflavan 0
                                          (\{6-[2-(3,4-dihydroxyphenyl)-4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-8-yl]-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-6-yl]-3,4,5-trihydroxyoxan-2-yl\}methoxy)sulfonic acid 0
                                          2-(3,4-dihydroxyphenyl)-4-[3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl]-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,4-dihydro-2H-1-benzopyran-3,5,7-triol 0
                                          3,3'-Digalloylprocyanidin B2 0
                                          3-O-alpha-L-Arabinopyranosylproanthocyanidin A5' 0
                                          5,13-bis(3,4-dihydroxyphenyl)-18-[3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-4,12,14-trioxapentacyclo[11.7.1.0?,??.0?,?.0??,??]henicosa-2(11),3(8),9,15(20),16,18-hexaene-6,9,17,19,21-pentol 0
                                          5-(3,4-dihydroxyphenyl)-18-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-4-yl]-13-(4-hydroxy-3-methoxyphenyl)-4,12,14-trioxapentacyclo[11.7.1.0?,??.0?,?.0??,??]henicosa-2(11),3(8),9,15(20),16,18-hexaene-6,9,17,19,21-pentol 0
                                          Catechin-(4alpha->8)-gallocatechin-(4alpha->8)-catechin 0
                                          Dihydromorelloflavone 0
                                          Epicatechin 3-O-gallate-(4beta->6)-epigallocatechin 3-O-gallate 0
                                          Epicatechin-(2beta->5,4beta->6)-ent-epicatechin 0
                                          Epicatechin-(2beta->7,4beta->6)-catechin 0
                                          Epicatechin-(4beta->6)-epicatechin-(2beta->7,4beta->8)-epicatechin 0
                                          Epigallocatechin-(4beta->8)-catechin 0
                                          Gallocatechin-(4alpha->8)-catechin-(4alpha->8)-catechin 0
                                          Gallocatechin-(4alpha->8)-gallocatechin-(4alpha->8)-gallocatechin 0
                                          Proanthocyanidin A1 0
                                          biflavonoid + 128
                                          ent-Epiafzelechin(2a->7,4a->8)epiafzelechin 3-(4-hydroxybenzoic acid) 0
                                          ent-Epicatechin(4alpha->8)catechin 0
                                          ent-Epicatechin-(4alpha->6)-ent-epicatechin 0
                                          proanthocyanidin + 99
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