CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: flavonoid oligomer
Accession: CHEBI:72720
browse the term
Definition: A phenylpropanoid obtained by the coupling of two or more units of aryl-substituted benzopyran units and their substituted derivatives.
Synonyms: related_synonym: flavonoid oligomers
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Arg1
arginase 1
multiple interactions
EXP
agathisflavone promotes the reaction [Excitatory Amino Acid Agonists results in increased expression of ARG1 mRNA]
CTD
PMID:29425760
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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Bdnf
brain-derived neurotrophic factor
multiple interactions increases expression
EXP
agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of BDNF mRNA] agathisflavone results in increased expression of BDNF mRNA
CTD
PMID:29425760
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Casp3
caspase 3
multiple interactions
EXP
agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of CASP3 protein modified form]
CTD
PMID:29425760
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cdnf
cerebral dopamine neurotrophic factor
increases expression
EXP
agathisflavone results in increased expression of CDNF mRNA
CTD
PMID:29425760
NCBI chr17:74,714,564...74,728,639
Ensembl chr17:74,713,564...74,728,639
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Gdnf
glial cell derived neurotrophic factor
multiple interactions
EXP
agathisflavone promotes the reaction [Excitatory Amino Acid Agonists results in increased expression of GDNF mRNA]
CTD
PMID:29425760
NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
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Glul
glutamate-ammonia ligase
multiple interactions
EXP
[agathisflavone co-treated with Excitatory Amino Acid Agonists] results in increased expression of GLUL protein
CTD
PMID:29425760
NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
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Il10
interleukin 10
multiple interactions increases expression
EXP
agathisflavone promotes the reaction [Excitatory Amino Acid Agonists results in increased expression of IL10 mRNA] agathisflavone results in increased expression of IL10 mRNA
CTD
PMID:29425760
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1b
interleukin 1 beta
multiple interactions
EXP
agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of IL1B mRNA]
CTD
PMID:29425760
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions increases expression
EXP
agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of IL6 mRNA] agathisflavone results in increased expression of IL6 mRNA
CTD
PMID:29425760
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itgam
integrin subunit alpha M
multiple interactions
EXP
agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of ITGAM protein]
CTD
PMID:29425760
NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
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Mrc1
mannose receptor, C type 1
increases expression
EXP
agathisflavone results in increased expression of MRC1 protein
CTD
PMID:29425760
NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
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Ngf
nerve growth factor
multiple interactions
EXP
[agathisflavone co-treated with Excitatory Amino Acid Agonists] results in increased expression of NGF mRNA
CTD
PMID:29425760
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Ntf4
neurotrophin 4
multiple interactions increases expression
EXP
[agathisflavone co-treated with Excitatory Amino Acid Agonists] results in increased expression of NTF4 mRNA agathisflavone results in increased expression of NTF4 mRNA
CTD
PMID:29425760
NCBI chr 1:95,893,560...95,896,391
Ensembl chr 1:95,893,457...95,897,243
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Slc1a3
solute carrier family 1 member 3
increases expression multiple interactions
EXP
agathisflavone results in increased expression of SLC1A3 protein agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of SLC1A3 protein]
CTD
PMID:29425760
NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605
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Tnf
tumor necrosis factor
multiple interactions
EXP
agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of TNF mRNA]
CTD
PMID:29425760
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Abca1
ATP binding cassette subfamily A member 1
multiple interactions
ISO
amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]
CTD
PMID:34599948
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Aif1
allograft inflammatory factor 1
multiple interactions
ISO
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AIF1 protein]
CTD
PMID:28185818
NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein]
CTD
PMID:28185818
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
CTD
PMID:28185818
NCBI chr13:22,689,783...22,853,920
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Casp3
caspase 3
multiple interactions
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]
CTD
PMID:28185818
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cd36
CD36 molecule
multiple interactions
ISO
amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 protein]; CD36 protein inhibits the reaction [amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PPARG protein]]
CTD
PMID:34599948
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions
ISO
amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CDKN1A protein]
CTD
PMID:28185818
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
amentoflavone results in decreased activity of CYP1B1 protein
CTD
PMID:16271822
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Dct
dopachrome tautomerase
decreases expression
ISO
amentoflavone analog results in decreased expression of DCT mRNA; amentoflavone analog results in decreased expression of DCT protein
CTD
PMID:17473463
NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836
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Gfap
glial fibrillary acidic protein
multiple interactions
ISO
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein]
CTD
PMID:28185818
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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Il1b
interleukin 1 beta
multiple interactions
ISO
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]
CTD
PMID:28185818
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]
CTD
PMID:28185818
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]
CTD
PMID:28185818
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Nos2
nitric oxide synthase 2
decreases expression multiple interactions
ISO
amentoflavone results in decreased expression of NOS2 protein amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]
CTD
PMID:12144868 PMID:28185818
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PPARG protein]; CD36 protein inhibits the reaction [amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PPARG protein]]
CTD
PMID:34599948
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ptgds
prostaglandin D2 synthase
affects binding
ISO
amentoflavone binds to PTGDS protein
CTD
PMID:26456343
NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression multiple interactions
ISO
amentoflavone results in decreased expression of PTGS2 mRNA; amentoflavone results in decreased expression of PTGS2 protein [amentoflavone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone
CTD
PMID:12144868
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Srebf1
sterol regulatory element binding transcription factor 1
decreases expression
ISO
amentoflavone results in decreased expression of SREBF1 mRNA
CTD
PMID:34599948
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Th
tyrosine hydroxylase
multiple interactions
ISO
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]
CTD
PMID:28185818
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Tyr
tyrosinase
decreases activity
ISO
amentoflavone analog results in decreased activity of TYR protein
CTD
PMID:17473463
NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
decreases activity
ISO
amentoflavone results in decreased activity of UGT1A1 protein
CTD
PMID:29470958
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
decreases activity
ISO
amentoflavone results in decreased activity of UGT1A3 protein
CTD
PMID:29470958
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a5
UDP glucuronosyltransferase family 1 member A5
decreases activity
ISO
amentoflavone results in decreased activity of UGT1A4 protein
CTD
PMID:29470958
NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a6
UDP glucuronosyltransferase family 1 member A6
decreases activity multiple interactions
ISO
amentoflavone results in decreased activity of UGT1A6 protein amentoflavone inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 4-cresol]
CTD
PMID:29470958 PMID:32421801
NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
decreases activity
ISO
amentoflavone results in decreased activity of UGT1A9 protein
CTD
PMID:29470958
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt2b17
UDP glucuronosyltransferase family 2 member B17
decreases activity
ISO
amentoflavone results in decreased activity of UGT2B17 protein
CTD
PMID:29470958
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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Hexb
hexosaminidase subunit beta
multiple interactions
ISO
cupressuflavone inhibits the reaction [Oxazolone results in increased secretion of HEXB protein]
CTD
PMID:29258854
NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
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Il4
interleukin 4
multiple interactions
ISO
cupressuflavone inhibits the reaction [Oxazolone results in increased secretion of IL4 protein]
CTD
PMID:29258854
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein] ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]
CTD
PMID:25968939
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]
CTD
PMID:25968939
NCBI chr13:22,689,783...22,853,920
G
Casp3
caspase 3
multiple interactions
ISO
ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein]
CTD
PMID:25968939
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Ftl1
ferritin light chain 1
decreases expression
ISO
ginkgetin results in decreased expression of FTL1 protein ginkgetin results in decreased expression of FTL protein
CTD
PMID:25968939
NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
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Tfrc
transferrin receptor
increases expression
ISO
ginkgetin results in increased expression of TFRC protein
CTD
PMID:25968939
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Th
tyrosine hydroxylase
multiple interactions
ISO
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]
CTD
PMID:25968939
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
hinokiflavone results in increased expression of BAX protein
CTD
PMID:30575109 PMID:32252563
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
hinokiflavone results in decreased expression of BCL2 protein
CTD
PMID:30575109 PMID:32252563
NCBI chr13:22,689,783...22,853,920
G
Casp3
caspase 3
increases expression increases cleavage
ISO
hinokiflavone results in increased expression of CASP3 protein hinokiflavone results in increased cleavage of CASP3 protein
CTD
PMID:30575109 PMID:32252563
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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F3
coagulation factor III, tissue factor
multiple interactions
ISO
hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein]; hinokiflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of F3 protein]
CTD
PMID:8882428
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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Il1b
interleukin 1 beta
multiple interactions
ISO
hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein]
CTD
PMID:8882428
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD
PMID:29673161
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD
PMID:29673161
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD
PMID:29673161
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mmp2
matrix metallopeptidase 2
decreases expression
ISO
hinokiflavone results in decreased expression of MMP2 mRNA; hinokiflavone results in decreased expression of MMP2 protein
CTD
PMID:29635122 PMID:30575109
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
decreases expression
ISO
hinokiflavone results in decreased expression of MMP9 protein hinokiflavone results in decreased expression of MMP9 mRNA; hinokiflavone results in decreased expression of MMP9 protein
CTD
PMID:29635122 PMID:30575109
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:29673161
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Prpf40a
pre-mRNA processing factor 40 homolog A
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of PRPF40A protein
CTD
PMID:28884683
NCBI chr 3:37,625,585...37,689,859
Ensembl chr 3:37,627,690...37,690,886
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Ptgds
prostaglandin D2 synthase
affects binding
ISO
hinokiflavone binds to PTGDS protein
CTD
PMID:26456343
NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD
PMID:29673161
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
CTD
PMID:29673161
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Senp1
SUMO specific peptidase 1
decreases activity
ISO
hinokiflavone results in decreased activity of SENP1 protein
CTD
PMID:28884683
NCBI chr 7:129,163,173...129,226,766
Ensembl chr 7:129,165,774...129,221,598
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Sf3a2
splicing factor 3A subunit 2
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of SF3A2 protein
CTD
PMID:28884683
NCBI chr 7:8,909,507...8,916,104
Ensembl chr 7:8,909,507...8,915,530
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Sf3b1
splicing factor 3b, subunit 1
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of SF3B1 protein
CTD
PMID:28884683
NCBI chr 9:56,492,403...56,532,300
Ensembl chr 9:56,492,403...56,532,300
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Sf3b2
splicing factor 3b, subunit 2
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of SF3B2 protein
CTD
PMID:28884683
NCBI chr 1:202,570,423...202,590,774
Ensembl chr 1:202,570,423...202,590,759
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Snrpd2
small nuclear ribonucleoprotein D2 polypeptide
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of SNRPD2 protein
CTD
PMID:28884683
NCBI chr 1:78,798,377...78,801,227
Ensembl chr 1:78,798,377...78,803,351
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Sumo1
small ubiquitin-like modifier 1
increases localization
ISO
hinokiflavone results in increased localization of SUMO1 protein
CTD
PMID:28884683
NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761
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Sumo2
small ubiquitin-like modifier 2
increases localization
ISO
hinokiflavone results in increased localization of SUMO2 protein
CTD
PMID:28884683
NCBI chr10:100,771,941...100,784,503
Ensembl chr10:100,686,797...100,784,513
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Sumo3
small ubiquitin-like modifier 3
increases localization
ISO
hinokiflavone results in increased localization of SUMO3 protein
CTD
PMID:28884683
NCBI chr20:11,010,140...11,020,850
Ensembl chr20:11,010,166...11,020,696
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Timp2
TIMP metallopeptidase inhibitor 2
increases expression
ISO
hinokiflavone results in increased expression of TIMP2 mRNA; hinokiflavone results in increased expression of TIMP2 protein
CTD
PMID:30575109
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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Tnf
tumor necrosis factor
multiple interactions
ISO
hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD
PMID:29673161
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
U2surp
U2 snRNP-associated SURP domain containing
increases sumoylation
ISO
hinokiflavone results in increased sumoylation of U2SURP protein
CTD
PMID:28884683
NCBI chr 8:96,018,932...96,075,795
Ensembl chr 8:96,022,957...96,075,691
G
Abcc1
ATP binding cassette subfamily C member 1
multiple interactions
ISO
Proanthocyanidins inhibits the reaction [Arsenic Trioxide results in decreased expression of ABCC1 protein]
CTD
PMID:31355259
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
G
Ace
angiotensin I converting enzyme
decreases activity
EXP
Proanthocyanidins results in decreased activity of ACE protein
CTD
PMID:16390204
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
G
Ache
acetylcholinesterase
multiple interactions
ISO
Proanthocyanidins inhibits the reaction [Cadmium results in decreased activity of ACHE protein]
CTD
PMID:25463594
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
G
Acta2
actin alpha 2, smooth muscle
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of ACTA2 protein]
CTD
PMID:33484087
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
G
App
amyloid beta precursor protein
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of APP protein modified form]
CTD
PMID:25088297
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
G
As3mt
arsenite methyltransferase
multiple interactions
ISO
Proanthocyanidins promotes the reaction [Arsenic Trioxide results in increased expression of AS3MT protein]
CTD
PMID:31355259
NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872
G
Atf1
activating transcription factor 1
multiple interactions
ISO
Proanthocyanidins inhibits the reaction [quinocetone metabolite results in decreased expression of ATF1 mRNA]
CTD
PMID:26802905
NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions increases expression
EXP ISO
Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of BAX protein] Proanthocyanidins results in increased expression of BAX mRNA; Proanthocyanidins results in increased expression of BAX protein
CTD
PMID:18611398 PMID:29654773
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
EXP ISO
Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] Proanthocyanidins results in decreased expression of BCL2 mRNA; Proanthocyanidins results in decreased expression of BCL2 protein
CTD
PMID:18611398 PMID:29654773
NCBI chr13:22,689,783...22,853,920
G
Bcl2l11
Bcl2-like 11
decreases expression
ISO
Proanthocyanidins results in decreased expression of BCL2L11 mRNA
CTD
PMID:29205955
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
G
Casp3
caspase 3
decreases expression increases cleavage increases expression
ISO
Proanthocyanidins results in decreased expression of CASP3 mRNA Proanthocyanidins results in increased cleavage of CASP3 protein Proanthocyanidins results in increased expression of CASP3 mRNA
CTD
PMID:29205955 PMID:29654773
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Cat
catalase
increases activity multiple interactions
ISO EXP
Proanthocyanidins results in increased activity of CAT protein Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]
CTD
PMID:29205955 PMID:33484087
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccr2
C-C motif chemokine receptor 2
decreases expression
ISO
proanthocyanidin results in decreased expression of CCR2 mRNA
CTD
PMID:12462994
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
G
Ccr3
C-C motif chemokine receptor 3
decreases expression
ISO
proanthocyanidin results in decreased expression of CCR3 mRNA; proanthocyanidin results in decreased expression of CCR3 protein
CTD
PMID:12462994
NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
G
Ccr5
C-C motif chemokine receptor 5
decreases expression
ISO
proanthocyanidin results in decreased expression of CCR5 mRNA
CTD
PMID:12462994
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
G
Cdk4
cyclin-dependent kinase 4
multiple interactions increases expression
EXP
Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased expression of CDK4 protein] Proanthocyanidins results in increased expression of CDK4 protein
CTD
PMID:33484087
NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
G
Cdkn2a
cyclin-dependent kinase inhibitor 2A
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of CDKN2A protein]
CTD
PMID:33484087
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
G
Ckb
creatine kinase B
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Proanthocyanidins results in decreased expression of [CKM protein binds to CKB protein]
CTD
PMID:33484087
NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
G
Ckm
creatine kinase, M-type
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Proanthocyanidins results in decreased expression of [CKM protein binds to CKB protein]
CTD
PMID:33484087
NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
G
Creb1
cAMP responsive element binding protein 1
multiple interactions
ISO
Proanthocyanidins inhibits the reaction [quinocetone metabolite affects the expression of CREB1 mRNA]
CTD
PMID:26802905
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
G
Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
multiple interactions
ISO
Proanthocyanidins affects the reaction [cyadox metabolite affects the expression of CYP11B1 protein]; Proanthocyanidins affects the reaction [Mequindox metabolite results in decreased expression of CYP11B1 protein]; Proanthocyanidins affects the reaction [quinocetone metabolite affects the expression of CYP11B1 mRNA]; Proanthocyanidins affects the reaction [quinocetone metabolite affects the expression of CYP11B1 protein]; Proanthocyanidins inhibits the reaction [cyadox metabolite results in decreased expression of CYP11B1 mRNA]; Proanthocyanidins inhibits the reaction [Mequindox metabolite results in decreased expression of CYP11B1 mRNA]
CTD
PMID:26802905
NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
G
Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
multiple interactions
ISO
Proanthocyanidins affects the reaction [cyadox metabolite affects the expression of CYP11B2 mRNA]; Proanthocyanidins affects the reaction [cyadox metabolite affects the expression of CYP11B2 protein]; Proanthocyanidins affects the reaction [Mequindox metabolite results in decreased expression of CYP11B2 protein]; Proanthocyanidins affects the reaction [quinocetone metabolite affects the expression of CYP11B2 protein]; Proanthocyanidins inhibits the reaction [Mequindox metabolite results in decreased expression of CYP11B2 mRNA]; Proanthocyanidins inhibits the reaction [quinocetone metabolite results in decreased expression of CYP11B2 mRNA]
CTD
PMID:26802905
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
G
Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of EIF2AK3 protein]
CTD
PMID:25088297
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
G
Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of EIF2S1 protein]
CTD
PMID:25088297
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
G
Ern1
endoplasmic reticulum to nucleus signaling 1
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of ERN1 protein]
CTD
PMID:25088297
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
affects binding multiple interactions
EXP
Proanthocyanidins binds to HMGCR protein Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of HMGCR protein]
CTD
PMID:30273964
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
G
Hnf4a
hepatocyte nuclear factor 4, alpha
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HNF4A mRNA]
CTD
PMID:30273964
NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
G
Hspa5
heat shock protein family A (Hsp70) member 5
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of HSPA5 protein]
CTD
PMID:25088297
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
G
Il1b
interleukin 1 beta
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of IL1B protein]
CTD
PMID:25088297
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il2
interleukin 2
decreases expression multiple interactions
EXP
Proanthocyanidins results in decreased expression of IL2 protein Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of IL2 protein]
CTD
PMID:33484087
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il6
interleukin 6
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]
CTD
PMID:33484087
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Lcat
lecithin cholesterol acyltransferase
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LCAT protein]
CTD
PMID:30273964
NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
G
Ldlr
low density lipoprotein receptor
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of LDLR mRNA]
CTD
PMID:30273964
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
G
Lpl
lipoprotein lipase
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LPL protein]
CTD
PMID:30273964
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
G
Mapk8
mitogen-activated protein kinase 8
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of MAPK8 protein]
CTD
PMID:25088297
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
G
Mapk9
mitogen-activated protein kinase 9
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of MAPK9 protein]
CTD
PMID:25088297
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
G
Mapt
microtubule-associated protein tau
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of MAPT protein]
CTD
PMID:25088297
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
G
Nr4a1
nuclear receptor subfamily 4, group A, member 1
multiple interactions
ISO
Proanthocyanidins inhibits the reaction [quinocetone metabolite affects the expression of NR4A1 mRNA]
CTD
PMID:26802905
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
G
Nr4a2
nuclear receptor subfamily 4, group A, member 2
multiple interactions
ISO
Proanthocyanidins inhibits the reaction [quinocetone metabolite results in decreased expression of NR4A2 mRNA]
CTD
PMID:26802905
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
G
Nr5a1
nuclear receptor subfamily 5, group A, member 1
multiple interactions
ISO
Proanthocyanidins inhibits the reaction [quinocetone metabolite affects the expression of NR5A1 mRNA]
CTD
PMID:26802905
NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328
G
Odc1
ornithine decarboxylase 1
multiple interactions
ISO
Proanthocyanidins inhibits the reaction [3-chloroperbenzoic acid results in increased activity of ODC1 protein]
CTD
PMID:7653998
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
G
Pon1
paraoxonase 1
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein]
CTD
PMID:30273964
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]
CTD
PMID:25088297
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
G
Rb1
RB transcriptional corepressor 1
multiple interactions increases expression
EXP
Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased expression of RB1 protein] Proanthocyanidins results in increased expression of RB1 protein
CTD
PMID:33484087
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [lead acetate affects the localization of RELA protein]
CTD
PMID:25088297
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Snca
synuclein alpha
decreases expression
ISO
Proanthocyanidins results in decreased expression of SNCA protein
CTD
PMID:29976995
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]
CTD
PMID:33484087
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Tnf
tumor necrosis factor
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of TNF protein]
CTD
PMID:25088297 PMID:33484087
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnni1
troponin I1, slow skeletal type
multiple interactions
EXP
Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of TNNI1 protein]
CTD
PMID:33484087
NCBI chr13:47,229,217...47,241,640
Ensembl chr13:47,229,216...47,241,644
G
Tp53
tumor protein p53
increases expression
ISO
Proanthocyanidins results in increased expression of TP53 mRNA; Proanthocyanidins results in increased expression of TP53 protein
CTD
PMID:29654773
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Cdk1
cyclin-dependent kinase 1
decreases phosphorylation
ISO
procyanidin results in decreased phosphorylation of CDK1 protein
CTD
PMID:15827326
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
G
Foxo1
forkhead box O1
decreases phosphorylation
ISO
procyanidin results in decreased phosphorylation of FOXO1 protein
CTD
PMID:15827326
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
G
Rb1
RB transcriptional corepressor 1
multiple interactions
ISO
procyanidin results in decreased phosphorylation of and results in decreased expression of RB1 protein
CTD
PMID:15827326
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
G
Tp53
tumor protein p53
decreases phosphorylation
ISO
procyanidin results in decreased phosphorylation of TP53 protein
CTD
PMID:15827326
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Ager
advanced glycosylation end product-specific receptor
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of AGER protein]
CTD
PMID:25199697
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
G
Akt1
AKT serine/threonine kinase 1
increases phosphorylation
ISO
procyanidin B2 results in increased phosphorylation of AKT1 protein
CTD
PMID:21945981
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Alb
albumin
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of ALB protein]
CTD
PMID:25199697
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
G
Atg12
autophagy related 12
multiple interactions
ISO
[Diquat co-treated with procyanidin B2] results in increased expression of ATG12 mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of ATG12 mRNA
CTD
PMID:27057282
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions decreases expression
ISO
procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of BAX protein] procyanidin B2 affects the reaction [Diquat affects the expression of BAX mRNA]; procyanidin B2 affects the reaction [Hydrogen Peroxide affects the expression of BAX mRNA] procyanidin B2 results in decreased expression of BAX protein
CTD
PMID:21505870 PMID:27057282
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
procyanidin B2 affects the reaction [Diquat affects the expression of BCL2 mRNA]; procyanidin B2 affects the reaction [Hydrogen Peroxide affects the expression of BCL2 mRNA]
CTD
PMID:27057282
NCBI chr13:22,689,783...22,853,920
G
Bcl2l11
Bcl2-like 11
multiple interactions
ISO
procyanidin B2 inhibits the reaction [Diquat results in increased expression of BCL2L11 mRNA]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of BCL2L11 mRNA]
CTD
PMID:27057282
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
G
Becn1
beclin 1
multiple interactions
ISO
[Diquat co-treated with procyanidin B2] results in increased expression of BECN1 mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of BECN1 mRNA
CTD
PMID:27057282
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
G
Brca1
BRCA1, DNA repair associated
increases expression
ISO
procyanidin B2 results in increased expression of BRCA1 mRNA
CTD
PMID:25839702
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
G
Casp1
caspase 1
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Paraquat results in increased expression of CASP1 protein]
CTD
PMID:30025709
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
G
Casp3
caspase 3
multiple interactions decreases expression
ISO
procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of CASP3 protein modified form] 3-methyladenine inhibits the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; FOXO1 protein affects the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; procyanidin B2 inhibits the reaction [Diquat results in increased expression of CASP3 mRNA]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA] procyanidin B2 results in decreased expression of CASP3 protein modified form
CTD
PMID:21505870 PMID:27057282
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp9
caspase 9
decreases activity multiple interactions
ISO
procyanidin B2 results in decreased activity of CASP9 protein procyanidin B2 inhibits the reaction [MFGE8 protein results in increased activity of CASP9 protein]
CTD
PMID:21505870
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Cat
catalase
multiple interactions
ISO EXP
procyanidin B2 inhibits the reaction [Diquat results in decreased activity of CAT protein] procyanidin B2 inhibits the reaction [Carrageenan results in decreased activity of CAT protein]
CTD
PMID:27057282 PMID:28844677
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccl2
C-C motif chemokine ligand 2
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]
CTD
PMID:25199697
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Cdh1
cadherin 1
increases expression
ISO
procyanidin B2 results in increased expression of CDH1 mRNA
CTD
PMID:25839702
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
G
Cycs
cytochrome c, somatic
affects localization multiple interactions
ISO
procyanidin B2 affects the localization of CYCS protein procyanidin B2 inhibits the reaction [MFGE8 protein affects the localization of CYCS protein]
CTD
PMID:21505870
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
G
Dnmt1
DNA methyltransferase 1
increases expression
ISO
procyanidin B2 results in increased expression of DNMT1 mRNA
CTD
PMID:25839702
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
G
Dnmt3a
DNA methyltransferase 3 alpha
increases expression
ISO
procyanidin B2 results in increased expression of DNMT3A mRNA
CTD
PMID:25839702
NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
G
Dnmt3b
DNA methyltransferase 3 beta
increases expression
ISO
procyanidin B2 results in increased expression of DNMT3B mRNA
CTD
PMID:25839702
NCBI chr 3:142,130,592...142,169,124
Ensembl chr 3:142,130,592...142,169,124
G
Foxo1
forkhead box O1
multiple interactions
ISO
FOXO1 protein affects the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; procyanidin B2 inhibits the reaction [Diquat results in increased expression of FOXO1 mRNA]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of and affects the localization of FOXO1 protein]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO1 mRNA]
CTD
PMID:27057282
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
G
Gsk3b
glycogen synthase kinase 3 beta
increases expression multiple interactions
ISO
procyanidin B2 results in increased expression of GSK3B protein modified form procyanidin B2 inhibits the reaction [MFGE8 protein results in decreased expression of GSK3B protein modified form]
CTD
PMID:21505870
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Hmox1
heme oxygenase 1
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Carrageenan results in decreased expression of HMOX1 protein]
CTD
PMID:28844677
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Il10
interleukin 10
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Carrageenan results in increased secretion of IL10 protein]
CTD
PMID:28844677
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il18
interleukin 18
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL18 mRNA]; procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL18 protein]
CTD
PMID:30025709
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il1b
interleukin 1 beta
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL1B mRNA]; procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL1B protein]
CTD
PMID:30025709
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Carrageenan results in increased secretion of IL6 protein]
CTD
PMID:28844677
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Klk1b3
kallikrein 1-related peptidase B3
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Carrageenan results in increased expression of KLK3 protein]
CTD
PMID:28844677
NCBI chr 1:94,709,105...94,713,308
Ensembl chr 1:94,709,105...94,713,308
G
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions
ISO
[Diquat co-treated with procyanidin B2] results in increased expression of MAP1LC3B mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of MAP1LC3B mRNA
CTD
PMID:27057282
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
procyanidin B2 results in increased phosphorylation of MAPK1 protein
CTD
PMID:21945981
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
procyanidin B2 results in increased phosphorylation of MAPK3 protein
CTD
PMID:21945981
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mfge8
milk fat globule EGF and factor V/VIII domain containing
multiple interactions affects response to substance
ISO
procyanidin B2 inhibits the reaction [MFGE8 protein affects the localization of CYCS protein]; procyanidin B2 inhibits the reaction [MFGE8 protein results in decreased expression of GSK3B protein modified form]; procyanidin B2 inhibits the reaction [MFGE8 protein results in increased activity of CASP9 protein]; procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of BAX protein]; procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of CASP3 protein modified form] procyanidin B2 affects the susceptibility to MFGE8 protein
CTD
PMID:21505870
NCBI chr 1:133,064,665...133,080,069
Ensembl chr 1:133,064,665...133,080,073
G
Mir122
microRNA 122
decreases expression
EXP ISO
procyanidin B2 results in decreased expression of MIR122 mRNA
CTD
PMID:24165878
NCBI chr18:58,758,703...58,758,787
G
Mpo
myeloperoxidase
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Paraquat results in increased activity of MPO protein]
CTD
PMID:30025709
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Carrageenan affects the localization of NFE2L2 protein]
CTD
PMID:28844677
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
G
Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Paraquat results in increased expression of NLRP3 protein]
CTD
PMID:30025709
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
G
Nphs1
NPHS1 adhesion molecule, nephrin
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS1 mRNA]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS1 protein]
CTD
PMID:25199697
NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
G
Nphs2
NPHS2 stomatin family member, podocin
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS2 mRNA]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS2 protein]
CTD
PMID:25199697
NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
G
Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Carrageenan results in decreased expression of NQO1 protein]
CTD
PMID:28844677
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Pik3c3
phosphatidylinositol 3-kinase, catalytic subunit type 3
multiple interactions
ISO
[Diquat co-treated with procyanidin B2] results in increased expression of PIK3C3 mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of PIK3C3 mRNA
CTD
PMID:27057282
NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
G
Prkca
protein kinase C, alpha
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of PRKCA protein]
CTD
PMID:25199697
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
G
Pycard
PYD and CARD domain containing
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Paraquat results in increased expression of PYCARD protein]
CTD
PMID:30025709
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
G
Serpinb5
serpin family B member 5
increases expression
ISO
procyanidin B2 results in increased expression of SERPINB5 mRNA
CTD
PMID:25839702
NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756
G
Tnf
tumor necrosis factor
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Carrageenan results in increased expression of TNF protein]
CTD
PMID:28844677
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Top2a
DNA topoisomerase II alpha
decreases activity
ISO
procyanidin B2 results in decreased activity of TOP2A protein
CTD
PMID:16536579
NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
G
Vcam1
vascular cell adhesion molecule 1
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]
CTD
PMID:25199697
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
G
Vegfa
vascular endothelial growth factor A
multiple interactions
EXP
procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]
CTD
PMID:25199697
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Ager
advanced glycosylation end product-specific receptor
multiple interactions
ISO
[Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of AGER mRNA
CTD
PMID:22169119
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
G
Cat
catalase
multiple interactions
ISO
[Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of CAT mRNA
CTD
PMID:22169119
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
CTD
PMID:22169119
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Ccl5
C-C motif chemokine ligand 5
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]
CTD
PMID:22169119
NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
G
Ccl7
C-C motif chemokine ligand 7
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL7 mRNA]
CTD
PMID:22169119
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
G
Cd80
Cd80 molecule
multiple interactions
ISO
procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 mRNA]
CTD
PMID:22169119
NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
G
Csf2
colony stimulating factor 2
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 mRNA]
CTD
PMID:22169119
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
G
Fas
Fas cell surface death receptor
multiple interactions
ISO
procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of FAS mRNA]
CTD
PMID:22169119
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
ISO
[Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of GCLM mRNA
CTD
PMID:22169119
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Hmox1
heme oxygenase 1
multiple interactions
ISO
[Eicosapentaenoic Acid co-treated with procyanidin B3] promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]
CTD
PMID:22169119
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Il10
interleukin 10
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]
CTD
PMID:22169119
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il12b
interleukin 12B
multiple interactions
ISO
procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]
CTD
PMID:22169119
NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
G
Il1b
interleukin 1 beta
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD
PMID:22169119
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il2ra
interleukin 2 receptor subunit alpha
multiple interactions
ISO
procyanidin B3 promotes the reaction [Lipopolysaccharides results in increased expression of IL2RA mRNA]
CTD
PMID:22169119
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
G
Il6
interleukin 6
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD
PMID:22169119
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Map3k8
mitogen-activated protein kinase kinase kinase 8
multiple interactions
ISO
[Eicosapentaenoic Acid co-treated with procyanidin B3] inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA]; procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA]
CTD
PMID:22169119
NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216
G
Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
[Lipopolysaccharides co-treated with procyanidin B3] results in decreased phosphorylation of MAPK8 protein; Eicosapentaenoic Acid promotes the reaction [[Lipopolysaccharides co-treated with procyanidin B3] results in decreased phosphorylation of MAPK8 protein]; procyanidin B3 promotes the reaction [[Lipopolysaccharides co-treated with Eicosapentaenoic Acid] results in decreased phosphorylation of MAPK8 protein]
CTD
PMID:22169119
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
G
Msr1
macrophage scavenger receptor 1
multiple interactions
ISO
[Eicosapentaenoic Acid co-treated with procyanidin B3] promotes the reaction [Lipopolysaccharides results in increased expression of MSR1 mRNA]
CTD
PMID:22169119
NCBI chr16:52,717,775...52,802,890
Ensembl chr16:52,717,732...52,799,676
G
Nfkb2
nuclear factor kappa B subunit 2
multiple interactions
ISO
[Eicosapentaenoic Acid co-treated with procyanidin B3] inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB2 mRNA]
CTD
PMID:22169119
NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
procyanidin B3 inhibits the reaction [[Lipopolysaccharides co-treated with Eicosapentaenoic Acid] results in increased phosphorylation of RELA protein]
CTD
PMID:22169119
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Serpine1
serpin family E member 1
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]
CTD
PMID:22169119
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
G
Tnfrsf1b
TNF receptor superfamily member 1B
multiple interactions
ISO
procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B mRNA]
CTD
PMID:22169119
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
G
Abcb1a
ATP binding cassette subfamily B member 1A
decreases activity multiple interactions
ISO
sciadopitysin results in decreased activity of ABCB1 protein sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
CTD
PMID:30790579
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Bglap
bone gamma-carboxyglutamate protein
increases expression multiple interactions
ISO
sciadopitysin results in increased expression of BGLAP protein sciadopitysin inhibits the reaction [Antimycin A results in increased expression of BGLAP protein]
CTD
PMID:23624148
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
G
Tnf
tumor necrosis factor
multiple interactions
ISO
sciadopitysin inhibits the reaction [Antimycin A results in increased expression of TNF protein]
CTD
PMID:23624148
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Apc
APC regulator of WNT signaling pathway
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of APC mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of APC protein]
CTD
PMID:27058323
NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
G
Apoe
apolipoprotein E
multiple interactions
ISO
theaflavin inhibits the reaction [APOE gene mutant form results in decreased activity of NOS3 protein]; theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of PTGR1 protein]; theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of SELP protein]
CTD
PMID:20093625
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 mRNA]
CTD
PMID:18656336
NCBI chr13:22,689,783...22,853,920
G
Ccnd1
cyclin D1
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]
CTD
PMID:27058323
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
G
Cd44
CD44 molecule (Indian blood group)
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CD44 protein]
CTD
PMID:27058323
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
G
Cdh1
cadherin 1
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of CDH1 mRNA]
CTD
PMID:27058323
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions
ISO
[theaflavin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA]
CTD
PMID:23717041
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
G
Ctnnb1
catenin beta 1
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 protein]
CTD
PMID:27058323
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
G
Egfr
epidermal growth factor receptor
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of EGFR mRNA]
CTD
PMID:27058323
NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
G
Ercc1
ERCC excision repair 1, endonuclease non-catalytic subunit
multiple interactions
ISO
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ERCC1 mRNA]
CTD
PMID:23717041
NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
multiple interactions
ISO
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of GADD45A mRNA]
CTD
PMID:23717041
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
G
Gli1
GLI family zinc finger 1
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 protein]
CTD
PMID:27058323
NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
G
Hras
HRas proto-oncogene, GTPase
multiple interactions
ISO
theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]; theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]
CTD
PMID:18656336
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
G
Mdm2
MDM2 proto-oncogene
multiple interactions
ISO
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]
CTD
PMID:23717041
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
G
Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions
ISO
theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of MYC mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of MYC mRNA]
CTD
PMID:18656336 PMID:27058323
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Nos3
nitric oxide synthase 3
multiple interactions
ISO
theaflavin inhibits the reaction [APOE gene mutant form results in decreased activity of NOS3 protein]
CTD
PMID:20093625
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
G
Ptgr1
prostaglandin reductase 1
multiple interactions
ISO
theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of PTGR1 protein]
CTD
PMID:20093625
NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 mRNA]
CTD
PMID:23717041
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
G
Selp
selectin P
multiple interactions
ISO
theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of SELP protein]
CTD
PMID:20093625
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
G
Sfrp1
secreted frizzled-related protein 1
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 protein]
CTD
PMID:27058323
NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
G
Slc2a4
solute carrier family 2 member 4
multiple interactions
ISO
theaflavin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]
CTD
PMID:18591783
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
G
Smo
smoothened, frizzled class receptor
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO protein]
CTD
PMID:27058323
NCBI chr 4:58,344,101...58,372,828
Ensembl chr 4:58,343,529...58,373,829
G
Tp53
tumor protein p53
multiple interactions
ISO
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 mRNA]; theaflavin promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 mRNA]
CTD
PMID:18656336 PMID:23717041
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Xrcc1
X-ray repair cross complementing 1
multiple interactions
ISO
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC1 mRNA]
CTD
PMID:23717041
NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
G
Xrcc3
X-ray repair cross complementing 3
multiple interactions
ISO
[theaflavin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]
CTD
PMID:23717041
NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
20089
chemical entity
20088
atom
20058
nonmetal atom
19979
oxygen atom
19674
oxygen molecular entity
19674
flavonoids
11202
flavonoid oligomer
171
(2R,3R)-2-(3,4-Dihydroxyphenyl)-6-[(2R,3R,4S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3,4,5-trihydroxybenzoyloxy)-3,4-dihydro-2H-1-benzopyran-4-yl]-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate
0
(2S,2''S,3S,3''R,4S)-3,4',5,7-Tetrahydroxyflavan(2->7,4->8)-3,4',5,7-tetrahydroxyflavan
0
(5-\{4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-8-yl]-3,5,7-trihydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,4-dihydro-2H-1-benzopyran-2-yl\}-2-hydroxyphenyl)oxidanesulfonic acid
0
(5-\{8-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1-benzopyran-3-yl]-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-2-yl\}-2-hydroxyphenyl)oxidanesulfonic acid
0
(6-\{4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-8-yl]-3,5,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl\}-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl)oxidanesulfonic acid
0
(\{6-[2-(3,4-dihydroxyphenyl)-4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-8-yl]-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-6-yl]-3,4,5-trihydroxyoxan-2-yl\}methoxy)sulfonic acid
0
2-(3,4-Dihydroxyphenyl)-8-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-8-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
0
2-(3,4-dihydroxyphenyl)-4-[3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl]-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
0
2-(3-hydroxyphenyl)-4-[3,5,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl]-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
0
3,3',4',5,7-Pentahydroxyflavan(4->8)-3,4',5,7-tetrahydroxyflavan
0
3,3'-Digalloylprocyanidin B2
0
3,4,5-trihydroxy-6-(3-\{3,5,7-trihydroxy-4-[3,5,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl]-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,4-dihydro-2H-1-benzopyran-2-yl\}phenoxy)oxane-2-carboxylic acid
0
3,4,5-trihydroxy-6-\{[3-hydroxy-2-(3-hydroxyphenyl)-4-[3,5,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl]-3,4-dihydro-2H-1-benzopyran-7-yl]oxy\}oxane-2-carboxylic acid
0
3-O-alpha-L-Arabinopyranosylproanthocyanidin A5'
0
5,13-bis(3,4-dihydroxyphenyl)-18-[3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-4,12,14-trioxapentacyclo[11.7.1.0?,??.0?,?.0??,??]henicosa-2(11),3(8),9,15(20),16,18-hexaene-6,9,17,19,21-pentol
0
5,7-dihydroxy-3-[5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-oxo-7-\{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy\}-3,4-dihydro-2H-1-benzopyran-8-yl]-2-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
0
5-(3,4-dihydroxyphenyl)-18-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-4-yl]-13-(4-hydroxy-3-methoxyphenyl)-4,12,14-trioxapentacyclo[11.7.1.0?,??.0?,?.0??,??]henicosa-2(11),3(8),9,15(20),16,18-hexaene-6,9,17,19,21-pentol
0
6-(3-\{8-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,4-dihydro-2H-1-benzopyran-4-yl]-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-2-yl\}phenoxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
0
6-(4-\{8-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1-benzopyran-3-yl]-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-2-yl\}-2-hydroxyphenoxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
0
6-(\{8-[3,7-dihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-3,4-dihydro-2H-1-benzopyran-7-yl\}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
0
6-[3-(4-\{8-[3,7-dihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-3,5,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-6-yl\}-3,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-2-yl)phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
0
6-\{[8-(5,7-dihydroxy-4-oxo-2-phenyl-3,4-dihydro-2H-1-benzopyran-3-yl)-7-hydroxy-2-(3-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1-benzopyran-5-yl]oxy\}-3,4,5-trihydroxyoxane-2-carboxylic acid
0
8-[3,7-dihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-6-[3,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
0
8-[3,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-6-[2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-4-yl]-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
0
8-[5,7-Dihydroxy-3-(3,4,5-trihydroxybenzoyloxy)-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate
0
8-[5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one
0
Catechin-(4alpha->8)-gallocatechin-(4alpha->8)-catechin
0
Dihydromorelloflavone
0
Ephedrannin A
0
Epicatechin 3-O-gallate-(4beta->6)-epigallocatechin 3-O-gallate
0
Epicatechin-(2beta->5,4beta->6)-ent-epicatechin
0
Epicatechin-(2beta->7,4beta->6)-catechin
0
Epicatechin-(4beta->6)-epicatechin-(2beta->7,4beta->8)-epicatechin
0
Epigallocatechin-(4beta->8)-catechin
0
Gallocatechin-(4alpha->8)-catechin-(4alpha->8)-catechin
0
Gallocatechin-(4alpha->8)-gallocatechin-(4alpha->8)-gallocatechin
0
Nordracorubin
0
Pavetannin C1
0
Proanthocyanidin A1
0
[(6-\{4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-8-yl]-3,5,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl\}-3,4,5-trihydroxyoxan-2-yl)methoxy]sulfonic acid
0
\{2-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4-[3,5,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl]-3,4-dihydro-2H-1-benzopyran-8-yl]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl\}oxidanesulfonic acid
0
biflavonoid +
130
ent-Epiafzelechin(2a->7,4a->8)epiafzelechin 3-(4-hydroxybenzoic acid)
0
ent-Epicatechin(4alpha->8)catechin
0
ent-Epicatechin-(4alpha->6)-ent-epicatechin
0
ent-Epicatechin-(4alpha->8)-ent-epicatechin 3-gallate
0
proanthocyanidin +
100
Path 2
CHEBI ontology
20089
subatomic particle
20058
composite particle
20058
hadron
20088
baryon
20088
nucleon
20088
atomic nucleus
20088
atom
20058
main group element atom
19960
p-block element atom
19990
carbon group element atom
19916
carbon atom
19909
organic molecular entity
19909
organic molecule
19856
organic cyclic compound
19612
organic heterocyclic compound
18824
oxacycle
17688
benzopyran
11213
1-benzopyran
10951
flavonoid oligomer
171
(2R,3R)-2-(3,4-Dihydroxyphenyl)-6-[(2R,3R,4S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3,4,5-trihydroxybenzoyloxy)-3,4-dihydro-2H-1-benzopyran-4-yl]-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate
0
(2S,2''S,3S,3''R,4S)-3,4',5,7-Tetrahydroxyflavan(2->7,4->8)-3,4',5,7-tetrahydroxyflavan
0
(5-\{4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-8-yl]-3,5,7-trihydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,4-dihydro-2H-1-benzopyran-2-yl\}-2-hydroxyphenyl)oxidanesulfonic acid
0
(5-\{8-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1-benzopyran-3-yl]-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-2-yl\}-2-hydroxyphenyl)oxidanesulfonic acid
0
(6-\{4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-8-yl]-3,5,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl\}-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl)oxidanesulfonic acid
0
(\{6-[2-(3,4-dihydroxyphenyl)-4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-8-yl]-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-6-yl]-3,4,5-trihydroxyoxan-2-yl\}methoxy)sulfonic acid
0
2-(3,4-Dihydroxyphenyl)-8-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-8-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
0
2-(3,4-dihydroxyphenyl)-4-[3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl]-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
0
2-(3-hydroxyphenyl)-4-[3,5,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl]-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
0
3,3',4',5,7-Pentahydroxyflavan(4->8)-3,4',5,7-tetrahydroxyflavan
0
3,3'-Digalloylprocyanidin B2
0
3,4,5-trihydroxy-6-(3-\{3,5,7-trihydroxy-4-[3,5,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl]-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,4-dihydro-2H-1-benzopyran-2-yl\}phenoxy)oxane-2-carboxylic acid
0
3,4,5-trihydroxy-6-\{[3-hydroxy-2-(3-hydroxyphenyl)-4-[3,5,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl]-3,4-dihydro-2H-1-benzopyran-7-yl]oxy\}oxane-2-carboxylic acid
0
3-O-alpha-L-Arabinopyranosylproanthocyanidin A5'
0
5,13-bis(3,4-dihydroxyphenyl)-18-[3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-4,12,14-trioxapentacyclo[11.7.1.0?,??.0?,?.0??,??]henicosa-2(11),3(8),9,15(20),16,18-hexaene-6,9,17,19,21-pentol
0
5,7-dihydroxy-3-[5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-oxo-7-\{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy\}-3,4-dihydro-2H-1-benzopyran-8-yl]-2-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
0
5-(3,4-dihydroxyphenyl)-18-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-4-yl]-13-(4-hydroxy-3-methoxyphenyl)-4,12,14-trioxapentacyclo[11.7.1.0?,??.0?,?.0??,??]henicosa-2(11),3(8),9,15(20),16,18-hexaene-6,9,17,19,21-pentol
0
6-(3-\{8-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,4-dihydro-2H-1-benzopyran-4-yl]-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-2-yl\}phenoxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
0
6-(4-\{8-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1-benzopyran-3-yl]-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-2-yl\}-2-hydroxyphenoxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
0
6-(\{8-[3,7-dihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-3,4-dihydro-2H-1-benzopyran-7-yl\}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
0
6-[3-(4-\{8-[3,7-dihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-3,5,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-6-yl\}-3,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-2-yl)phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
0
6-\{[8-(5,7-dihydroxy-4-oxo-2-phenyl-3,4-dihydro-2H-1-benzopyran-3-yl)-7-hydroxy-2-(3-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-1-benzopyran-5-yl]oxy\}-3,4,5-trihydroxyoxane-2-carboxylic acid
0
8-[3,7-dihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-6-[3,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
0
8-[3,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-6-[2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-4-yl]-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
0
8-[5,7-Dihydroxy-3-(3,4,5-trihydroxybenzoyloxy)-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-yl]-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate
0
8-[5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one
0
Catechin-(4alpha->8)-gallocatechin-(4alpha->8)-catechin
0
Dihydromorelloflavone
0
Ephedrannin A
0
Epicatechin 3-O-gallate-(4beta->6)-epigallocatechin 3-O-gallate
0
Epicatechin-(2beta->5,4beta->6)-ent-epicatechin
0
Epicatechin-(2beta->7,4beta->6)-catechin
0
Epicatechin-(4beta->6)-epicatechin-(2beta->7,4beta->8)-epicatechin
0
Epigallocatechin-(4beta->8)-catechin
0
Gallocatechin-(4alpha->8)-catechin-(4alpha->8)-catechin
0
Gallocatechin-(4alpha->8)-gallocatechin-(4alpha->8)-gallocatechin
0
Nordracorubin
0
Pavetannin C1
0
Proanthocyanidin A1
0
[(6-\{4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-8-yl]-3,5,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl\}-3,4,5-trihydroxyoxan-2-yl)methoxy]sulfonic acid
0
\{2-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4-[3,5,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-8-yl]-3,4-dihydro-2H-1-benzopyran-8-yl]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl\}oxidanesulfonic acid
0
biflavonoid +
130
ent-Epiafzelechin(2a->7,4a->8)epiafzelechin 3-(4-hydroxybenzoic acid)
0
ent-Epicatechin(4alpha->8)catechin
0
ent-Epicatechin-(4alpha->6)-ent-epicatechin
0
ent-Epicatechin-(4alpha->8)-ent-epicatechin 3-gallate
0
proanthocyanidin +
100