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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2654
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gadd45a
Name: growth arrest and DNA-damage-inducible, alpha
Acc ID: CHEBI:136609
Term: theaflavin
Definition: A biflavonoid that is 3,4,5-trihydroxybenzocyclohepten-6-one which is substituted at positions 1 and 8 by (2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl groups. It is the main red pigment in black tea.
Chemical ID: MESH:C056068
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gadd45amultiple interactionsISOGadd45a (Mus musculus)6480464CTD[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of GADD45A mRNA]PMID:23717041
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