Gene:	Abcb1a ( Rattus norvegicus ) ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Description:	ATP-binding cassette (ABC) multiple drug transporter P-glycoprotein that is activated during liver regeneration and hepatocarcinogenesis
Synonyms:	multiple drug resistant 1a; Abcb1; Mdr1a; ATP-binding cassette, sub-family B (MDR/TAP), member 1;
ArrayIDs:	1370464_at; 6668418; 1370583_s_at; S66618_at; 5895570; 6247446; 6276903; 6253952; 6574248; 1370465_at; 6361510; 5695568; 6326477; 6098828; 6272544; 6625428; 6739095; rc_AI045221_at; 5813985; 6626563; 5619823; 5975570; 5741873; 6741153; 6469306; 6267936; GE1151117; 6171255; 6167416; 6231297; 6016868; 5782776; 5760636; 6566984; 6007333; A_44_P279083; 5730001; 6129825; 6703837; 6282355; 6327593; 5980846; 5840139; 6721437; 6221184; 5742066; A_42_P668953; 6145358; 6097230; 6358410; 5698086; 5800715; 6284395; 6198334;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: ABCB1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Abcb1a     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Abcb1a Rat Celera Assembly 4 20849575 - 20934573     RGSC genome assembly v3.4 4 21709855 - 21796628     Cytogenetic 4 q12     genome assembly 3.1 4 21709854 - 21796626 Mus musculus Abcb1a Mouse genome assembly build 36.1 5 8660092 - 8748519     Cytogenetic 5 5 A1 Homo sapiens ABCB1 human genome assembly 7 86777598 - 86987215     Human genome assembly build 36.2 7 86970884 - 87180500     Cytogenetic 7 q21.12   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology protein binding,  ATPase activity, coupled,  nucleotide binding ...  (details...)
Biological Process	Gene Ontology transmembrane transport,  response to drug,  response to cadmium ion ...  (details...)
Cellular Component	Gene Ontology nucleus,  focal adhesion,  intercellular canaliculus ...  (details...)
Disease	Note Reference mouse homolog Abcb1a/Mdr1a is activated in hepatocellular carcinomas   Ontology Diabetes Mellitus, Experimental,  Crohn Disease,  Colorectal Neoplasms ...  (details...)
Expression	Note Reference increased expression in hepatocellular carcinomas (HCCs) and during liver regeneration 632266
External Links
Databases	DATABASE ID SOURCE SMART: AAA IPI PROSITE: ABC_TM1F IPI PROSITE: ABC_TRANSPORTER_2 IPI PROSITE: ABC_TRANSPORTER_1 IPI UNIPARC: UPI0001B7B810 IPI UNIPARC: UPI0000DC0004 IPI UNIPARC: UPI00003594ED IPI KEGG Report: rno:170913 ENTREZGENE HomoloGene Group ID: 55496 ENTREZGENE Germonline: 619951 Pfam: ABC_tran IPI Pfam: ABC_membrane IPI KEGG Pathway: 02010 ENTREZGENE InterPro: ABC_transporter-like. IPI InterPro: ABC_TM_transpt. IPI InterPro: ABC_TM_1. IPI InterPro: ABC_transporter_type1. IPI InterPro: ABC_transporter_CS. IPI InterPro: ATPase_AAA+_core. IPI IPI: IPI00948527 IPI IPI: IPI00780231 IPI IPI: IPI00411189 IPI Ensembl Protein: ENSRNOP00000046799 IPI Ensembl Protein: ENSRNOP00000058019 IPI Ensembl Protein: ENSRNOP00000011166 IPI Entrez Gene: Abcb1a ENTREZGENE UniProt: Q9JK64_RAT IPI UniProt: Q924L6_RAT IPI UniProt: Q6PSM0_RAT IPI Ensembl Genes: ENSRNOG00000008012 IPI Superfamily-SCOP: ABC_TM_1 IPI
Sequences	Nucleotide: AF286167 Get FASTA Search GEO Profiles Nucleotide: NM_133401 Get FASTA Search GEO Profiles Nucleotide: AY582535 Get FASTA Search GEO Profiles Nucleotide: X61103 Get FASTA Search GEO Profiles Nucleotide: S66618 Get FASTA Search GEO Profiles Nucleotide: CH474013 Get FASTA Search GEO Profiles Nucleotide: AF257746 Get FASTA Search GEO Profiles (View all 7 Nucleotide Accessions) Protein: NP_596892 Get FASTA Protein: EDL84318 Get FASTA Protein: CAA43415 Get FASTA Protein: AAF69007 Get FASTA Protein: AAK83023 Get FASTA Protein: AAS91649 Get FASTA Protein: Q6PSM0 Get FASTA Protein: Q924L6 Get FASTA Protein: Q9JK64 Get FASTA (View all 9 Protein Accessions)
Clusters	UniGene: 154810
References
Curated References	14 references in RGD related to Abcb1a
Other References	10 other references at PubMed related to Abcb1a
Database Information
RGD ID	619951
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 06-AUG-09: Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A Abcb1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 29-AUG-08: Abcb1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 20-JAN-05: Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A APPROVED Symbol and Name status set to approved 1299863 07-AUG-02: Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A PROVISIONAL Symbol and Name status set to provisional 70820