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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:2430
Term: aconitine
Definition: A diterpenoid that is 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diol having acetate and benzoate groups at the 8- and 14-positions respectively.
Chemical ID: MESH:D000157
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aaffects response to substanceISOAbcb1a (Mus musculus)6480464CTDABCB1A gene mutant form affects the susceptibility to AconitinePMID:28193520
Abcb1aaffects transportISOABCB1 (Homo sapiens)6480464CTDABCB1 affects the transport of AconitinePMID:23562926
Abcb1adecreases response to substanceISOABCB1 (Homo sapiens)6480464CTDABCB1 results in decreased susceptibility to AconitinePMID:23562926
Abcb1amultiple interactionsISOAbcb1a (Mus musculus)6480464CTDABCB1A gene mutant form promotes the reaction [Aconitine results in increased expression of S100B protein]; ABCB1A gene mutant form results in decreased metabolism of and results in increased abundance of AconitinePMID:28193520
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