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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:18088
Term: formononetin
Definition: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'.
Chemical ID: MESH:C007768
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aaffects activityISOABCB1 (Homo sapiens)6480464CTDformononetin affects the activity of ABCB1 proteinPMID:15796199
Abcb1adecreases activityISOAbcb1a (Mus musculus)6480464CTDformononetin results in decreased activity of ABCB1 proteinPMID:27996361
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDformononetin results in increased expression of ABCB1 mRNAPMID:23867903
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [formononetin results in increased expression of ABCB1 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]; formononetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]PMID:23867903 PMID:34217736
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