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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:3764
Term: clotrimazole
Definition: A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.
Chemical ID: MESH:D003022
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aaffects bindingISOABCB1 (Homo sapiens)6480464CTDClotrimazole binds to ABCB1 proteinPMID:8917702
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDClotrimazole results in increased expression of ABCB1 proteinPMID:8632764
Abcb1amultiple interactionsISOAbcb1a (Mus musculus)6480464CTDClotrimazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]PMID:12235267
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTDClotrimazole inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]PMID:12235267 PMID:8917702
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