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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases activityEXP 6480464CTDCyclosporine results in decreased activity of ABCB1 protein; Cyclosporine results in decreased activity of ABCB1A proteinPMID:16118767 PMID:17609666
Abcb1amultiple interactionsEXP 6480464CTD[Cyclosporine results in decreased activity of ABCB1 protein] which results in increased uptake of carvedilol; [Thioacetamide co-treated with Cyclosporine] results in increased expression of ABCB1 mRNA; Cyclosporine inhibits the reaction [ABCB1 results in decreased susceptibility to Cadmium Chloride]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Paliperidone Palmitate]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Risperidone]PMID:10636889 PMID:15770714 PMID:16118767 PMID:17609666
Abcb1aaffects exportISOABCB1 (Homo sapiens)6480464CTDABCB1 protein affects the export of CyclosporinePMID:15964336
Abcb1aaffects expressionISOABCB1 (Homo sapiens)6480464CTDCyclosporine affects the expression of ABCB1 mRNAPMID:20106945
Abcb1aaffects response to substanceISOABCB1 (Homo sapiens)6480464CTDABCB1 protein affects the susceptibility to Cyclosporine; ABCB1 protein polymorphism affects the susceptibility to CyclosporinePMID:12387747 PMID:15772250 PMID:28623111
Abcb1aaffects transportISOABCB1 (Homo sapiens)6480464CTDABCB1 protein affects the transport of CyclosporinePMID:15964407
Abcb1adecreases activityISOAbcb1a (Mus musculus)6480464CTDCyclosporine results in decreased activity of ABCB1A proteinPMID:8949985
Abcb1adecreases activityISOABCB1 (Homo sapiens)6480464CTDCyclosporine results in decreased activity of ABCB1 protein; Cyclosporine results in decreased activity of ABCB1 protein mutant formPMID:12387747 PMID:12711602 PMID:16316932 PMID:18408562 PMID:31364238
Abcb1adecreases expressionISOABCB1 (Homo sapiens)6480464CTDCyclosporine results in decreased expression of ABCB1 mRNA; Cyclosporine results in decreased expression of ABCB1 proteinPMID:17096884 PMID:24973091 PMID:27989131 PMID:33631201
Abcb1aincreases exportISOAbcb1a (Mus musculus)6480464CTDABCB1A protein results in increased export of CyclosporinePMID:8949985
Abcb1aincreases expressionISOAbcb1a (Mus musculus)6480464CTDCyclosporine results in increased expression of ABCB1A mRNAPMID:19770486
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDCyclosporine results in increased expression of ABCB1 mRNAPMID:12387747 PMID:25562108
Abcb1aincreases transportISOABCB1 (Homo sapiens)6480464CTDABCB1 protein results in increased transport of Cyclosporine; ABCB1A protein results in increased transport of CyclosporinePMID:17045309
Abcb1amultiple interactionsISOAbcb1a (Mus musculus)6480464CTDABCB1A protein affects the susceptibility to [Pentobarbital co-treated with Cyclosporine]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]PMID:12235267 PMID:17959987
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD[Cyclosporine binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Cyclosporine co-treated with Raloxifene Hydrochloride] results in decreased expression of ABCB1 mRNA; [Cyclosporine co-treated with Raloxifene Hydrochloride] results in decreased expression of ABCB1 protein; [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylaconine; [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylhypaconine; [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylmesaconine; [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of hypaconitine; [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of mesaconitine; [Cyclosporine results in decreased activity of ABCB1 protein] which results in increased susceptibility to Paclitaxel; Cyclosporine binds to and results in decreased activity of ABCB1 protein; Cyclosporine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; Cyclosporine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Cyclosporine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; Cyclosporine inhibits the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Glucosylceramides]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Lactosylceramides]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased export of Diazinon]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased export of Fluorescent Dyes]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Daunorubicin]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Technetium Tc 99m Sestamibi]; Cyclosporine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]; Plant Extracts affects the reaction [ABCB1 protein results in increased transport of Cyclosporine]PMID:10617675 PMID:12235267 PMID:12526924 PMID:12545142 PMID:12711602 PMID:14662772 PMID:16221533 PMID:16636798 PMID:17096884 PMID:17947497 PMID:18673531 PMID:23200901 PMID:23976943 PMID:27450509 PMID:7905786
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