GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcb1a | decreases expression | EXP | | 6480464 | CTD | Cisplatin results in decreased expression of ABCB1 protein | PMID:33965372 | Abcb1a | decreases response to substance | EXP | | 6480464 | CTD | ABCB1 protein results in decreased susceptibility to Cisplatin | PMID:11455017 | Abcb1a | increases expression | EXP | | 6480464 | CTD | Cisplatin results in increased expression of ABCB1A protein | PMID:30452898 | Abcb1a | multiple interactions | EXP | | 6480464 | CTD | [Diethylnitrosamine co-treated with Cisplatin] results in increased expression of ABCB1 protein; Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1A protein] | PMID:11818250 PMID:30452898 | Abcb1a | affects response to substance | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | ABCB1 affects the susceptibility to Cisplatin; ABCB1 gene polymorphism affects the susceptibility to Cisplatin | PMID:15756446 PMID:16785472 | Abcb1a | decreases expression | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | Cisplatin results in decreased expression of ABCB1 mRNA; Cisplatin results in decreased expression of ABCB1 protein | PMID:25987058 | Abcb1a | decreases response to substance | ISO | Abcb1a (Mus musculus) | 6480464 | CTD | ABCB1 protein results in decreased susceptibility to Cisplatin | PMID:22269388 | Abcb1a | decreases response to substance | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | ABCB1 protein results in decreased susceptibility to Cisplatin | PMID:15990222 PMID:22269388 | Abcb1a | increases expression | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | Cisplatin results in increased expression of ABCB1 mRNA; Cisplatin results in increased expression of ABCB1 protein | PMID:15239124 PMID:15650019 PMID:15990222 PMID:27840903 PMID:30452898 PMID:32918990 | Abcb1a | multiple interactions | ISO | Abcb1a (Mus musculus) | 6480464 | CTD | ABCB1 protein inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; ABCB1 protein inhibits the reaction [Cisplatin results in increased activity of and results in increased cleavage of CASP3 protein]; ABCB1 protein inhibits the reaction [Cisplatin results in increased activity of CASP9 protein]; ABCB1 protein promotes the reaction [Cisplatin results in increased expression of TRP53 protein] | PMID:22269388 | Abcb1a | multiple interactions | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of ABCB1 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of ABCB1 protein; [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of ABCB1 mRNA; [Cisplatin results in increased acetylation of APEX1 protein] promotes the reaction [[APEX1 protein modified form binds to ABCB1 promoter] which results in increased expression of ABCB1 mRNA]; [Cisplatin results in increased acetylation of APEX1 protein] promotes the reaction [APEX1 protein modified form binds to ABCB1 promoter]; [CXCL8 results in increased expression of ABCB1 mRNA] which results in decreased susceptibility to Cisplatin; [CXCL8 results in increased expression of ABCB1 protein] which results in decreased susceptibility to Cisplatin; [Paclitaxel results in increased expression of ABCB1] which results in decreased susceptibility to Cisplatin; ABCB1 affects the reaction [HIF1A affects the susceptibility to Cisplatin]; ABCB1 gene SNP affects the susceptibility to [Cisplatin co-treated with Fluorouracil]; ABCB1 protein inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; ABCB1 protein inhibits the reaction [Cisplatin results in increased activity of and results in increased cleavage of CASP3 protein]; ABCB1 protein inhibits the reaction [Cisplatin results in increased activity of CASP9 protein]; ABCB1 protein promotes the reaction [Cisplatin results in increased expression of TRP53 protein]; Chloroquine promotes the reaction [Cisplatin results in decreased expression of ABCB1 mRNA]; Chloroquine promotes the reaction [Cisplatin results in decreased expression of ABCB1 protein]; Cisplatin promotes the reaction [[APEX1 protein modified form promotes the reaction [YBX1 protein binds to EP300 protein]] which binds to ABCB1 promoter]; kang-lai-te inhibits the reaction [Cisplatin results in increased expression of ABCB1 mRNA]; kang-lai-te inhibits the reaction [Cisplatin results in increased expression of ABCB1 protein]; Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1 protein] | PMID:20856196 PMID:21332314 PMID:21742513 PMID:21833476 PMID:21964646 PMID:22269388 PMID:25987058 PMID:30452898 PMID:30871063 PMID:32800223 PMID:32918990 | |
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