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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:9747
Term: Triptolide
Definition: An oxacycle that has formula C20H24O6.
Chemical ID: MESH:C001899
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases expressionEXP 6480464CTDtriptolide results in decreased expression of ABCB1A proteinPMID:33600922
Abcb1aincreases expressionEXP 6480464CTDtriptolide results in increased expression of ABCB1A proteinPMID:32519852
Abcb1adecreases response to substanceISOAbcb1a (Mus musculus)6480464CTDABCB1A protein results in decreased susceptibility to triptolidePMID:26134275
Abcb1amultiple interactionsISOAbcb1a (Mus musculus)6480464CTD[ABCB1A mutant form co-treated with triptolide] results in increased abundance of Malondialdehyde; ABCB1A mutant form promotes the reaction [triptolide results in decreased expression of BCL2 protein]; ABCB1A mutant form promotes the reaction [triptolide results in increased activity of GPT protein]; ABCB1A mutant form promotes the reaction [triptolide results in increased expression of BAX protein]PMID:26134275
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