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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:28821
Term: piperine
Definition: A N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum.
Chemical ID: MESH:C008922
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases expressionISOABCB1 (Homo sapiens)6480464CTDpiperine analog results in decreased expression of ABCB1 proteinPMID:37244399
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDpiperine results in increased expression of ABCB1 mRNA; piperine results in increased expression of ABCB1 proteinPMID:23707768
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTDKetoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]; NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]PMID:23707768
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