GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcb1a | affects response to substance | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | ABCB1 exon polymorphism affects the susceptibility to Etoposide | PMID:12969965 | Abcb1a | increases expression | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | Etoposide results in increased expression of ABCB1 mRNA; Etoposide results in increased expression of ABCB1 protein | PMID:15239124 PMID:27570640 PMID:27840903 | Abcb1a | multiple interactions | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [Celecoxib results in decreased expression of ABCB1] which results in increased susceptibility to Etoposide | PMID:19047049 PMID:19562670 | | ||||||||||||||||||||||
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