DOXORUBICIN PHARMACOKINETICS PATHWAY (PW:0001565)

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Description

Doxorubucin (DOX, trade name Adriamycin) is an anthracycline derived from Streptomyces bacterium Streptomyces peucetius var. caesius. DOX is used in the treatment of several solid cancers, leukemia and lymphomas. The drug is composed of a planar aromatic ring with an anthraquinone chromophore and a sugar group. Once taken up by the cell and inside the nucleus for which it has a high affinity, the planar ring structure intercalates between adjacent DNA base pairs, preferentia

Pathway Diagram:

Elsevier Inc. doxorubicin ---> doxorubicinol Ralbp1 Abcg2 Abcc3 Abcb1a Abcc2 Nos3 Nqo1 Xdh Cbr3 Cbr1 Akr1a1 Akr1c3 Slc22a16 ROS generation deglycosidation further processing doxorubicinol ---> elimination doxorubicin aglycone ---> elimination elimination doxorubicin one-electron reduction doxorubicin ---> doxorubicin semiquinone two-electron reduction Slc22a16 ---> doxorubicin doxorubicin semiquinone ---> elimination doxorubicin ---> elimination doxorubicin aglycone doxorubicinol doxorubicin semiquinone doxorubicin ---> doxorubicin aglycone
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Genes in Pathway:

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doxorubicin pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:10395261
RGD:10402751
G Abcc1 ATP binding cassette subfamily C member 1 JBrowse link 10 549,537 672,235 RGD:10402751
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:10395261
RGD:10402751
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:10395261
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:10395261
RGD:10402751
G Akr1a1 aldo-keto reductase family 1 member A1 JBrowse link 5 135,482,068 135,498,693 RGD:10395261
RGD:10402751
RGD:10395262
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:10395261
RGD:10402751
G Cbr1 carbonyl reductase 1 JBrowse link 11 33,813,041 33,815,418 RGD:10395261
RGD:10402751
RGD:10395262
G Cbr3 carbonyl reductase 3 JBrowse link 11 33,909,417 33,917,674 RGD:10395261
RGD:10402751
RGD:10395262
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 JBrowse link 13 89,606,848 89,623,506 RGD:10402751
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 JBrowse link 3 79,721,686 79,728,863 RGD:10402751
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 JBrowse link 7 12,318,776 12,326,403 RGD:10402751
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:10395262
RGD:10402751
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:10395262
RGD:10402751
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:10402751
G Ralbp1 ralA binding protein 1 JBrowse link 9 113,579,107 113,598,477 RGD:10395261
RGD:10402751
G Slc22a16 solute carrier family 22 member 16 JBrowse link 20 45,658,398 45,669,192 RGD:10395261
RGD:10402751
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:10395262
RGD:10402751

Pathway Gene Annotations

Disease Annotations Associated with Genes in the doxorubicin pharmacokinetics pathway
Disease TermsGene Symbols
Colitis, UlcerativeAbcb1a
Pathway Annotations Associated with Genes in the doxorubicin pharmacokinetics pathway
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayAkr1c3 , Cbr1
adenine phoshoribosyltransferase deficiency pathwayXdh
adenosine monophosphate deaminase deficiency pathwayXdh
adenylosuccinate lyase deficiency pathwayXdh
AICA-ribosuria pathwayXdh
aldosterone biosynthetic pathwayPor
Alzheimer disease pathwayNdufs2 , Ndufs3 , Ndufs7
antipyrine drug pathwayAkr1c3 , Cbr1
arachidonic acid metabolic pathwayAkr1c3 , Cbr1 , Cbr3
arginine and proline metabolic pathwayNos3
azathioprine pharmacodynamics pathwayXdh
bile acid transport pathwayAbcb1a , Abcc2 , Abcc3 , Abcg2
caffeine metabolic pathwayXdh
caffeine pharmacokinetics pathwayXdh
calcium/calcium-mediated signaling pathwayNos3
celecoxib pharmacodynamics pathwayAkr1c3 , Cbr1
ceramide signaling pathwayRalbp1
clopidogrel pharmacodynamics pathwayAbcb1a
clopidogrel pharmacokinetics pathwayAbcb1a
cortisol biosynthetic pathwayPor
diclofenac pharmacodynamics pathwayAkr1c3 , Cbr1
diflunisal pharmacodynamics pathwayAkr1c3 , Cbr1
docetaxel pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
dopa responsive dystonia disease pathwayCbr1
doxorubicin pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcg2 , Akr1a1 , Akr1c3 , Cbr1 , Cbr3 , Ndufs2 , Ndufs3 , Ndufs7 , Nos3 , Nqo1 , Por , Ralbp1 , Slc22a16 , Xdh
eicosanoid signaling pathwayNos3
erlotinib pharmacodynamics pathwayAbcb1a , Abcg2
estradiol biosynthetic pathwayPor
etodolac pharmacodynamics pathwayAkr1c3 , Cbr1
etoposide pharmacodynamics pathwayAbcb1a , Abcc3
etoposide pharmacokinetics pathwayAbcb1a , Abcc3
fenoprofen pharmacodynamics pathwayAkr1c3 , Cbr1
flurbiprofen pharmacodynamics pathwayAkr1c3 , Cbr1
gluconeogenesis pathwayAkr1a1
glycerolipid metabolic pathwayAkr1a1
glycolysis pathwayAkr1a1
glycolysis/gluconeogenesis pathwayAkr1a1
Huntington disease pathwayNdufs2 , Ndufs3 , Ndufs7
hypoxia inducible factor pathwayAbcb1a , Abcg2
ibuprofen pharmacodynamics pathwayAkr1c3 , Cbr1
indometacin pharmacodynamics pathwayAkr1c3 , Cbr1
indometacin pharmacodynamics pathwayAkr1c3 , Cbr1
irinotecan pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
irinotecan pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
isoprenoid metabolic pathwayAkr1c3
Kelley-Seegmiller syndrome pathwayXdh
ketoprofen pharmacodynamics pathwayAkr1c3 , Cbr1
ketorolac pharmacodynamics pathwayAkr1c3 , Cbr1
lamivudine pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcg2
Lesch-Nyhan syndrome pathwayXdh
leukotriene C4 synthase deficiency pathwayAkr1c3 , Cbr1
lornoxicam pharmacodynamics pathwayAkr1c3 , Cbr1
magnesium salicylate pharmacodynamics pathwayAkr1c3 , Cbr1
mefenamic acid pharmacodynamics pathwayAkr1c3 , Cbr1
meloxicam pharmacodynamics pathwayAkr1c3 , Cbr1
mercaptopurine pharmacodynamics pathwayXdh
mercaptopurine pharmacokinetics pathwayXdh
molybdenum cofactor deficiency pathwayXdh
multidrug resistance-associated protein mediated transport pathwayAbcc1 , Abcc2 , Abcc3
mycophenolic acid pharmacokinetics pathwayAbcb1a , Abcc2 , Abcg2
nabumetone pharmacodynamics pathwayAkr1c3 , Cbr1
naproxen pharmacodynamics pathwayAkr1c3 , Cbr1
oxidative phosphorylation pathwayNdufs2 , Ndufs3 , Ndufs7
oxidative stress response pathwayNqo1
pancreatic cancer pathwayRalbp1
paracetamol drug pathwayAkr1c3 , Cbr1
paracetamol pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcg2
Parkinson disease pathwayNdufs2 , Ndufs3 , Ndufs7
phenytoin pharmacodynamics pathwayNqo1
piroxicam pharmacodynamics pathwayAkr1c3 , Cbr1
prostaglandin biosynthetic pathwayAkr1a1 , Akr1c3 , Cbr1
purine metabolic pathwayXdh
purine nucleoside phosphorylase deficiency pathwayXdh
salicylic acid pharmacodynamics pathwayAkr1c3 , Cbr1
Segawa syndrome pathwayCbr1
sodium salicylate pharmacodynamics pathwayAkr1c3 , Cbr1
sphingosine 1-phosphate signaling pathwayAbcc1
steroid hormone biosynthetic pathwayPor
sulindac pharmacodynamics pathwayAkr1c3 , Cbr1
tenoxicam pharmacodynamics pathwayAkr1c3 , Cbr1
testosterone biosynthetic pathwayPor
tiaprofenic acid pharmacodynamics pathwayAkr1c3 , Cbr1
tioguanine pharmacodynamics pathwayXdh
tolmetin pharmacodynamics pathwayAkr1c3 , Cbr1
tramadol pharmacokinetics pathwayAbcc2
tyrosinemia type III disease pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
valdecoxib pharmacodynamics pathwayAkr1c3 , Cbr1
vascular endothelial growth factor signaling pathwayNos3
venlafaxine pharmacokinetics pathwayAbcb1a
vinblastine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Ralbp1
vincristine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Ralbp1
vindesine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Ralbp1
vinorelbine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Ralbp1
vitamin K metabolic pathwayNqo1
xanthinuria disease pathwayXdh
xanthinuria disease pathway, type IXdh
xanthinuria disease pathway, type IIXdh
Phenotype Annotations Associated with Genes in the doxorubicin pharmacokinetics pathway

References Associated with the doxorubicin pharmacokinetics pathway:

Ontology Path Diagram:

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