DOXORUBICIN PHARMACOKINETICS PATHWAY (PW:0001565)

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Description

Doxorubucin (DOX, trade name Adriamycin) is an anthracycline derived from Streptomyces bacterium Streptomyces peucetius var. caesius. DOX is used in the treatment of several solid cancers, leukemia and lymphomas. The drug is composed of a planar aromatic ring with an anthraquinone chromophore and a sugar group. Once taken up by the cell and inside the nucleus for which it has a high affinity, the planar ring structure intercalates between adjacent DNA base pairs, preferentia

Pathway Diagram:

Elsevier Inc. doxorubicin ---> doxorubicinol Ralbp1 Abcg2 Abcc3 Abcb1a Abcc2 Nos3 Nqo1 Xdh Cbr3 Cbr1 Akr1a1 Akr1c3 Slc22a16 ROS generation deglycosidation further processing doxorubicinol ---> elimination doxorubicin aglycone ---> elimination elimination doxorubicin one-electron reduction doxorubicin ---> doxorubicin semiquinone two-electron reduction Slc22a16 ---> doxorubicin doxorubicin semiquinone ---> elimination doxorubicin ---> elimination doxorubicin aglycone doxorubicinol doxorubicin semiquinone doxorubicin ---> doxorubicin aglycone
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Genes in Pathway:

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doxorubicin pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:10395261
RGD:10402751
G Abcc1 ATP binding cassette subfamily C member 1 JBrowse link 10 549,537 672,235 RGD:10402751
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:10395261
RGD:10402751
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:10395261
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 JBrowse link 4 88,765,441 88,890,268 RGD:10395261
RGD:10402751
G Akr1a1 aldo-keto reductase family 1 member A1 JBrowse link 5 135,482,068 135,498,693 RGD:10395261
RGD:10395262
RGD:10402751
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:10395261
RGD:10402751
G Cbr1 carbonyl reductase 1 JBrowse link 11 33,813,041 33,815,418 RGD:10395261
RGD:10395262
RGD:10402751
G Cbr3 carbonyl reductase 3 JBrowse link 11 33,909,417 33,917,674 RGD:10395261
RGD:10395262
RGD:10402751
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 JBrowse link 13 89,606,848 89,623,506 RGD:10402751
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 JBrowse link 3 79,721,686 79,728,863 RGD:10402751
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 JBrowse link 7 12,318,776 12,326,403 RGD:10402751
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:10395262
RGD:10402751
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:10395262
RGD:10402751
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:10402751
G Ralbp1 ralA binding protein 1 JBrowse link 9 113,579,107 113,598,477 RGD:10395261
RGD:10402751
G Slc22a16 solute carrier family 22 member 16 JBrowse link 20 45,658,398 45,669,192 RGD:10395261
RGD:10402751
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:10395262
RGD:10402751

Pathway Gene Annotations

Disease Annotations Associated with Genes in the doxorubicin pharmacokinetics pathway
Disease TermsGene Symbols
Abruptio PlacentaeNos3
Acute Chest SyndromeNos3
Acute Kidney InjuryNos3 , Nqo1 , Xdh
Acute Lung InjuryNqo1
AdenocarcinomaNos3
AdenomaAbcg2
Adrenal Hyperplasia, CongenitalPor
Adrenocortical CarcinomaAbcb1a
AlopeciaAbcc2
Alzheimer DiseaseNos3
AmenorrheaPor
Anemia, Sickle CellNos3
AnoxiaNos3
Anthracycline-induced CardiotoxicityAbcb1a
Antley-Bixler Syndrome PhenotypePor
Antley-Bixler Syndrome with Genital Anomalies and Disordered SteroidogenesisPor
ANTLEY-BIXLER SYNDROME WITHOUT GENITAL ANOMALIES OR DISORDERED STEROIDOGENESISPor
ArteriosclerosisNos3
Arteriovenous FistulaNos3
Arthritis, ExperimentalAbcb1a , Abcg2 , Nqo1
Arthritis, JuvenileSlc22a16
Arthritis, RheumatoidAbcb1a , Abcc2 , Abcc3 , Abcg2
AsthmaAbcb1a , Abcc1 , Nos3 , Nqo1
AtherosclerosisNos3
Atrial FibrillationNos3
Autistic DisorderXdh
Behcet SyndromeAbcb1a , Nos3
Bipolar DisorderNdufs7
Brain InjuriesNqo1
Brain IschemiaNos3
Breast Cancer, FamilialAbcc1
Breast NeoplasmsAbcb1a , Abcc1 , Abcg2 , Ndufs3 , Nos3 , Nqo1
Bronchial HyperreactivityNos3
Bronchiolitis ObliteransNos3
Carbon Tetrachloride PoisoningNqo1
CarcinomaAbcb1a , Xdh
Carcinoma, Ductal, BreastAbcb1a
Carcinoma, HepatocellularAbcb1a , Abcc3 , Cbr1 , Xdh
Carcinoma, Intraductal, NoninfiltratingAkr1c3
Carcinoma, Non-Small-Cell LungAbcb1a , Abcc2 , Nqo1
Carcinoma, Renal CellAbcb1a , Abcg2
Carcinoma, Small CellNqo1
Carcinoma, Squamous Cell of Head and NeckAbcb1a , Abcc1 , Abcc2 , Abcg2
CardiomegalyNos3
CardiomyopathiesCbr1 , Ndufs2 , Nos3 , Xdh
Cardiomyopathy, HypertrophicNdufs2
CardiotoxicityNos3
Cardiovascular DiseasesNos3 , Xdh
Carotid Artery DiseasesXdh
Cell Transformation, NeoplasticAkr1c3 , Por
Cerebral InfarctionNos3
Child Behavior DisordersNos3
CholangiocarcinomaAbcc2
CholestasisAbcc2 , Abcc3 , Nos3 , Nqo1
Chromosome 8, TrisomyNqo1
Cleft LipNos3
Cleft PalateNos3
ColitisNos3
Colitis, UlcerativeAbcb1a
Colonic NeoplasmsCbr1 , Nqo1
Colorectal NeoplasmsAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcg2 , Nqo1
Coronary Artery DiseaseNos3
Coronary VasospasmNos3
Crohn DiseaseAbcb1a
Cystic FibrosisNos3
Depressive Disorder, MajorXdh
Dermatitis, ContactNqo1
Dermatitis, IrritantCbr1
Diabetes Mellitus, ExperimentalAbcb1a , Abcc2 , Abcc3 , Abcg2 , Cbr1 , Ndufs2 , Ndufs3 , Nos3 , Nqo1
Diabetes Mellitus, Type 1Nos3
Diabetes Mellitus, Type 2Abcb1a , Abcc2 , Nos3
Diabetic AngiopathiesNos3
Diabetic CardiomyopathiesXdh
Diabetic NephropathiesNos3 , Nqo1 , Xdh
Diabetic RetinopathyNos3
Disease ProgressionAbcb1a , Abcc1
Disorders of Sex DevelopmentAkr1c3
Drug HypersensitivityAbcc2
Drug-Induced Immune ThrombocytopeniaAbcc2
Drug-Induced Liver InjuryAbcb1a , Abcc1 , Abcc2
Drug-induced NeutropeniaAbcb1a , Abcc2
Drug-Related Side Effects and Adverse ReactionsAbcb1a , Abcc1 , Abcc2 , Abcg2
EncephalitisAbcb1a
Endometrial NeoplasmsAkr1c3 , Nos3
EndometriosisAkr1c3
EndotoxemiaAbcb1a , Abcc2 , Nos3
Enterocolitis, NecrotizingAbcb1a , Akr1a1 , Nos3
EosinophiliaAbcb1a
EpilepsyAbcb1a
Epilepsy, Familial Temporal Lobe, 3Abcb1a
Epilepsy, Temporal LobeAbcb1a
Erectile DysfunctionNos3
Escherichia Coli InfectionsAbcb1a
Esophageal NeoplasmsAbcb1a , Nos3
Esophageal Squamous Cell CarcinomaAbcc2
Fatty LiverAbcc2 , Abcc3 , Nqo1
Fetal Growth RetardationAbcb1a , Nos3
FeverCbr1
Gastrointestinal DiseasesAbcc2
Genetic Predisposition to DiseaseAbcb1a
Glaucoma, Angle-ClosureNos3
Glaucoma, Primary Open AngleNos3
GliomaNos3
GliosarcomaPor
Graft Occlusion, VascularNos3
Guanidinoacetate Methyltransferase DeficiencyNdufs7
Hearing Loss, SuddenNos3
Heart Defects, CongenitalAbcb1a
Heart DiseasesAbcb1a , Abcc1 , Abcc2 , Xdh
Heart FailureNos3 , Xdh
Hematologic NeoplasmsAbcb1a
Hemolytic-Uremic SyndromeNqo1
HemorrhageNqo1
HepatomegalyAbcc3
Hepatopulmonary SyndromeNos3
Hernia, DiaphragmaticNos3
HIV InfectionsAbcb1a
Huntington DiseaseNos3
HyperbilirubinemiaAbcc2 , Abcc3
HyperglycemiaNos3 , Nqo1
HyperinsulinismNos3
HyperlipidemiasAbcb1a , Nos3
HyperoxiaNos3 , Nqo1
Hyperoxic Lung InjuryNqo1
HyperprolactinemiaAbcc3
HypertensionAbcc1 , Nos3 , Nqo1 , Ralbp1 , Xdh
Hypertension Resistant to Conventional TherapyNos3
Hypertension, EssentialNos3
Hypertension, PortalNos3
Hypertension, Pregnancy-InducedNos3
Hypertension, PulmonaryNos3
Hypertension, RenalNos3
Hypertension, RenovascularNos3
HypertriglyceridemiaNos3
Hypertrophy, Left VentricularNos3 , Nqo1 , Xdh
Hypertrophy, Right VentricularNos3
HyperuricemiaXdh
HypotensionPor
Hypotension, OrthostaticAbcb1a
Hypoxia, BrainNos3
Infarction, Middle Cerebral ArteryNqo1 , Xdh
Infertility, MaleNos3
InflammationAbcb1a
Inflammatory Bowel Disease 13Abcb1a
Insulin ResistanceNos3
Intestinal PerforationNos3
Intestinal PolyposisAbcb1a
Intimal HyperplasiaNos3
Intracranial AneurysmNos3
Irritable Bowel SyndromeNos3
IschemiaNos3 , Xdh
Jaundice, Chronic IdiopathicAbcc2 , Abcc3
Kidney DiseasesAbcb1a , Abcc3 , Nqo1
Kidney Failure, ChronicAbcb1a , Abcc2 , Abcc3 , Cbr1 , Nos3
Kidney NeoplasmsAbcb1a
Kidney Reperfusion InjuryNqo1 , Xdh
Learning DisordersPor
Leigh DiseaseNdufs2 , Ndufs3 , Ndufs7
Leigh Syndrome Due To Mitochondrial Complex I DeficiencyNdufs3 , Ndufs7
LeiomyomaNos3
Lesch-Nyhan SyndromeXdh
LeukemiaAkr1c3 , Nqo1
Leukemia, Lymphocytic, Chronic, B-CellAbcg2
Leukemia, Megakaryoblastic, AcuteAbcg2
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveAbcb1a , Abcc2 , Abcg2 , Nqo1
Leukemia, MyeloidNqo1
Leukemia, Myeloid, AcuteAbcc3 , Abcg2 , Nos3 , Nqo1
Limb IschemiaNos3
Liver CirrhosisNos3
Liver Cirrhosis, BiliaryAbcc2 , Abcg2
Liver Cirrhosis, ExperimentalAbcb1a , Abcc2 , Akr1c3 , Nos3
Liver DiseasesNqo1
Liver Failure, AcuteAbcc2 , Nos3
Liver InjuryAbcg2
Liver NeoplasmsNqo1
Lung DiseasesNos3 , Nqo1
Lung NeoplasmsNqo1
Lung Reperfusion InjuryNqo1
LymphangioleiomyomatosisNos3
Lymphatic MetastasisNos3
Lymphoma, B-CellAbcg2
Lymphoma, Extranodal NK-T-CellAbcb1a
Lymphoma, Large B-Cell, DiffuseAbcb1a , Abcg2
Macular DegenerationNqo1
Macular EdemaNos3
Mammary Neoplasms, AnimalXdh
Mammary Neoplasms, ExperimentalAbcb1a , Abcg2 , Xdh
Marijuana AbuseAbcb1a
Mental DisordersAbcb1a
Metabolic Syndrome XNos3
Metabolism, Inborn ErrorsNdufs2
Migraine DisordersNos3
Mitochondrial Complex I DeficiencyNdufs2 , Ndufs3 , Ndufs7
Mitochondrial EncephalomyopathiesNdufs2
Mouth NeoplasmsCbr3
Multiple MyelomaAbcg2 , Nqo1
Multiple SclerosisNdufs2
Musculoskeletal AbnormalitiesPor
Myeloproliferative DisordersAkr1c3 , Nqo1
Myocardial InfarctionNos3
Myocardial IschemiaNos3 , Ralbp1
Myocardial Reperfusion InjuryNos3
Nasal PolypsAbcb1a , Nos3
NauseaAbcb1a
Neoplasm MetastasisAbcb1a , Nos3
NeoplasmsAbcb1a , Nos3 , Nqo1
Neoplasms, ExperimentalNqo1
Neoplasms, Germ Cell and EmbryonalAbcb1a
Neoplasms, Hormone-DependentAkr1c3
NephritisNos3
Nerve DegenerationXdh
Nervous System DiseasesAbcb1a , Abcc2 , Abcg2
Neural Tube DefectsPor
NeuroblastomaAbcb1a
Neurotoxicity SyndromesAbcb1a , Abcg2 , Nqo1
NeutropeniaAbcb1a
Non-alcoholic Fatty Liver DiseaseAbcb1a , Abcc3
ObesityAkr1c3 , Nos3 , Nqo1
Occupational DiseasesNqo1
Optic AtrophyNdufs3
Optic Neuropathy, IschemicNos3
Ovarian NeoplasmsAbcb1a , Abcg2 , Nos3
PainNos3
Pain, PostoperativeAbcb1a
Pancreatic NeoplasmsAbcc2 , Abcc3
PancreatitisXdh
Pancreatitis, Experimental, Chronic Nqo1
PapillomaNqo1
Parkinson DiseaseAbcb1a , Nqo1
Parkinson Disease, SecondaryAbcb1a
Peripheral Nervous System DiseasesAbcb1a , Abcc1
Phyllodes TumorNos3
Pleomorphic Xanthoastrocytoma Abcb1a , Por
Pneumonia, BacterialAbcc1
PneumoperitoneumXdh
PoisoningAbcb1a , Nqo1
Polycystic Kidney DiseasesNos3
Polycystic Ovary SyndromeAkr1c3
Pre-EclampsiaAkr1c3 , Nos3
Precursor B-Cell Lymphoblastic Leukemia-LymphomaAkr1c3
Precursor Cell Lymphoblastic Leukemia-LymphomaAbcb1a , Abcc2 , Abcg2 , Nos3 , Nqo1
Precursor T-Cell Lymphoblastic Leukemia-LymphomaAbcg2 , Akr1c3
Prostatic NeoplasmsAkr1c3 , Cbr1 , Nos3 , Nqo1 , Ralbp1
Prostatic Neoplasms, Castration-ResistantAkr1c3
Pseudoxanthoma ElasticumAbcc1
Pulmonary Disease, Chronic ObstructiveAbcc1 , Nos3 , Nqo1
Pulmonary EdemaNos3
Pulmonary EmbolismNos3 , Xdh
Pulmonary EmphysemaNos3 , Nqo1
Pulmonary EosinophiliaNos3
Pulmonary Hypertension, Hypoxia-Induced Nos3
Purine-Pyrimidine Metabolism, Inborn ErrorsXdh
Radiation PneumonitisNos3
Renal FibrosisNqo1 , Xdh
Renal InsufficiencyXdh
Renal Insufficiency, ChronicCbr1 , Nqo1 , Xdh
Reperfusion InjuryAbcb1a , Abcg2 , Nos3 , Xdh
Respiratory HypersensitivityNos3
Retina Reperfusion InjuryNos3
Retinal DegenerationNos3
Retinopathy of PrematurityNos3
Rhinitis, AllergicAbcb1a
Rhinitis, Allergic, PerennialNos3
SchizophreniaAbcc1
SeizuresAbcb1a , Abcc2 , Nqo1
SepsisNos3 , Xdh
Shock, HemorrhagicNos3
Sleep Apnea, CentralNos3
Sleep Apnea, ObstructiveAbcb1a , Nos3
Smith-Magenis SyndromeAbcc3
Spinal Cord InjuriesNos3 , Nqo1
Spinocerebellar Ataxia 17Nqo1
Status EpilepticusAbcb1a , Abcc2 , Abcg2
Stomach NeoplasmsAkr1c3 , Nos3
Stomach UlcerNos3
StrokeNos3
Subarachnoid HemorrhageNos3 , Nqo1
Tachycardia, VentricularNos3
TelangiectasisNos3
Testis Reperfusion InjuryXdh
ThrombocytopeniaXdh
ThromboembolismNos3
Thrombotic MicroangiopathiesNos3
Translocation, GeneticAbcb1a
UremiaNos3
Ureteral ObstructionNos3 , Nqo1
URIC ACID CONCENTRATION, SERUM, QUANTITATIVE TRAIT LOCUS 1Abcg2
Urinary Bladder Neck ObstructionNos3
Urinary Bladder NeoplasmsNos3 , Nqo1 , Por , Ralbp1 , Xdh
Urologic NeoplasmsNqo1
VasculitisNos3
Vaso-occlusive CrisisNos3
Venous ThrombosisNos3
Ventricular Dysfunction, RightNos3
Ventricular Premature ComplexesNos3
Vestibular DiseasesNos3
VomitingAbcb1a
Vulvar NeoplasmsNos3
Warfarin SensitivityNqo1
Wet Macular DegenerationNos3
Wilms TumorAbcb1a
Xanthinuria, Type IXdh
Pathway Annotations Associated with Genes in the doxorubicin pharmacokinetics pathway
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayAkr1c3 , Cbr1
adenine phoshoribosyltransferase deficiency pathwayXdh
adenosine monophosphate deaminase deficiency pathwayXdh
adenylosuccinate lyase deficiency pathwayXdh
AICA-ribosuria pathwayXdh
aldosterone biosynthetic pathwayPor
Alzheimer disease pathwayNdufs2 , Ndufs3 , Ndufs7
antipyrine drug pathwayAkr1c3 , Cbr1
arachidonic acid metabolic pathwayAkr1c3 , Cbr1 , Cbr3
arginine and proline metabolic pathwayNos3
azathioprine pharmacodynamics pathwayXdh
bile acid transport pathwayAbcb1a , Abcc2 , Abcc3 , Abcg2
caffeine metabolic pathwayXdh
caffeine pharmacokinetics pathwayXdh
calcium/calcium-mediated signaling pathwayNos3
celecoxib pharmacodynamics pathwayAkr1c3 , Cbr1
ceramide signaling pathwayRalbp1
clopidogrel pharmacodynamics pathwayAbcb1a
clopidogrel pharmacokinetics pathwayAbcb1a
cortisol biosynthetic pathwayPor
diclofenac pharmacodynamics pathwayAkr1c3 , Cbr1
diflunisal pharmacodynamics pathwayAkr1c3 , Cbr1
docetaxel pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
dopa responsive dystonia disease pathwayCbr1
doxorubicin pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcg2 , Akr1a1 , Akr1c3 , Cbr1 , Cbr3 , Ndufs2 , Ndufs3 , Ndufs7 , Nos3 , Nqo1 , Por , Ralbp1 , Slc22a16 , Xdh
eicosanoid signaling pathwayNos3
erlotinib pharmacodynamics pathwayAbcb1a , Abcg2
estradiol biosynthetic pathwayPor
etodolac pharmacodynamics pathwayAkr1c3 , Cbr1
etoposide pharmacodynamics pathwayAbcb1a , Abcc3
etoposide pharmacokinetics pathwayAbcb1a , Abcc3
fenoprofen pharmacodynamics pathwayAkr1c3 , Cbr1
flurbiprofen pharmacodynamics pathwayAkr1c3 , Cbr1
gluconeogenesis pathwayAkr1a1
glycerolipid metabolic pathwayAkr1a1
glycolysis pathwayAkr1a1
glycolysis/gluconeogenesis pathwayAkr1a1
Huntington disease pathwayNdufs2 , Ndufs3 , Ndufs7
hypoxia inducible factor pathwayAbcb1a , Abcg2
ibuprofen pharmacodynamics pathwayAkr1c3 , Cbr1
indometacin pharmacodynamics pathwayAkr1c3 , Cbr1
indometacin pharmacodynamics pathwayAkr1c3 , Cbr1
irinotecan pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
irinotecan pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
isoprenoid metabolic pathwayAkr1c3
Kelley-Seegmiller syndrome pathwayXdh
ketoprofen pharmacodynamics pathwayAkr1c3 , Cbr1
ketorolac pharmacodynamics pathwayAkr1c3 , Cbr1
lamivudine pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcg2
Lesch-Nyhan syndrome pathwayXdh
leukotriene C4 synthase deficiency pathwayAkr1c3 , Cbr1
lornoxicam pharmacodynamics pathwayAkr1c3 , Cbr1
magnesium salicylate pharmacodynamics pathwayAkr1c3 , Cbr1
mefenamic acid pharmacodynamics pathwayAkr1c3 , Cbr1
meloxicam pharmacodynamics pathwayAkr1c3 , Cbr1
mercaptopurine pharmacodynamics pathwayXdh
mercaptopurine pharmacokinetics pathwayXdh
molybdenum cofactor deficiency pathwayXdh
multidrug resistance-associated protein mediated transport pathwayAbcc1 , Abcc2 , Abcc3
mycophenolic acid pharmacokinetics pathwayAbcb1a , Abcc2 , Abcg2
nabumetone pharmacodynamics pathwayAkr1c3 , Cbr1
naproxen pharmacodynamics pathwayAkr1c3 , Cbr1
oxidative phosphorylation pathwayNdufs2 , Ndufs3 , Ndufs7
oxidative stress response pathwayNqo1
pancreatic cancer pathwayRalbp1
paracetamol drug pathwayAkr1c3 , Cbr1
paracetamol pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcg2
Parkinson disease pathwayNdufs2 , Ndufs3 , Ndufs7
phenytoin pharmacodynamics pathwayNqo1
piroxicam pharmacodynamics pathwayAkr1c3 , Cbr1
prostaglandin biosynthetic pathwayAkr1a1 , Akr1c3 , Cbr1
purine metabolic pathwayXdh
purine nucleoside phosphorylase deficiency pathwayXdh
salicylic acid pharmacodynamics pathwayAkr1c3 , Cbr1
Segawa syndrome pathwayCbr1
sodium salicylate pharmacodynamics pathwayAkr1c3 , Cbr1
sphingosine 1-phosphate signaling pathwayAbcc1
steroid hormone biosynthetic pathwayPor
sulindac pharmacodynamics pathwayAkr1c3 , Cbr1
tenoxicam pharmacodynamics pathwayAkr1c3 , Cbr1
testosterone biosynthetic pathwayPor
tiaprofenic acid pharmacodynamics pathwayAkr1c3 , Cbr1
tioguanine pharmacodynamics pathwayXdh
tolmetin pharmacodynamics pathwayAkr1c3 , Cbr1
tramadol pharmacokinetics pathwayAbcc2
tyrosinemia type III disease pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
valdecoxib pharmacodynamics pathwayAkr1c3 , Cbr1
vascular endothelial growth factor signaling pathwayNos3
venlafaxine pharmacokinetics pathwayAbcb1a
vinblastine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Ralbp1
vincristine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Ralbp1
vindesine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Ralbp1
vinorelbine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Ralbp1
vitamin K metabolic pathwayNqo1
xanthinuria disease pathwayXdh
xanthinuria disease pathway, type IXdh
xanthinuria disease pathway, type IIXdh
Phenotype Annotations Associated with Genes in the doxorubicin pharmacokinetics pathway

References Associated with the doxorubicin pharmacokinetics pathway:

Ontology Path Diagram:

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