GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcb1a | increases acetylation | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | Tretinoin results in increased acetylation of ABCB1 promoter | PMID:16223781 | Abcb1a | increases expression | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | Tretinoin results in increased expression of ABCB1 mRNA | PMID:16223781 | Abcb1a | multiple interactions | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | [[Tretinoin co-treated with romidepsin] results in increased expression of ABCB1 mRNA] which results in decreased susceptibility to Doxorubicin; [Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of ABCB1 protein; [Tretinoin co-treated with romidepsin] results in increased expression of ABCB1 protein; romidepsin promotes the reaction [Tretinoin results in increased expression of ABCB1 mRNA]; Tretinoin promotes the reaction [romidepsin results in increased acetylation of ABCB1 promoter]; valspodar inhibits the reaction [[[Tretinoin co-treated with romidepsin] results in increased expression of ABCB1 mRNA] which results in decreased susceptibility to Doxorubicin] | PMID:16223781 PMID:23284745 | | ||||||||||||||||||||||
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