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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:34887
Term: nickel dichloride
Definition: A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Chemical ID: MESH:C022838
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases response to substanceEXP 6480464CTDABCB1 protein results in decreased susceptibility to nickel chloridePMID:24448832
Abcb1aincreases expressionEXP 6480464CTDnickel chloride results in increased expression of ABCB1 mRNA; nickel chloride results in increased expression of ABCB1 proteinPMID:24448832
Abcb1amultiple interactionsEXP 6480464CTDalpha-Tocopherol inhibits the reaction [nickel chloride results in increased expression of ABCB1 protein]; fumonisin B1 inhibits the reaction [nickel chloride results in increased expression of ABCB1 protein]PMID:24448832
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